[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INDUCTION, AND TISSUE SPECIFICITY.
TISSUE=Retinal pigment epithelium;
DOI=10.1074/jbc.M007421200; PubMed=11042181 [NCBI, ExPASy, EBI, Israel, Japan]
Kutty R.K.,
Kutty G.,
Samuel W.,
Duncan T.,
Bridges C.C.,
El-Sherbeeny A.,
Nagineni C.N.,
Smith S.B.,
Wiggert B.;
"Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid.";
J. Biol. Chem. 276:2831-2840(2001).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
TISSUE=Testis;
DOI=10.1111/j.1745-7262.2005.00040.x; PubMed=16110356 [NCBI, ExPASy, EBI, Israel, Japan]
Yuan W.,
Zheng Y.,
Huo R.,
Lu L.,
Huang X.-Y.,
Yin L.-L.,
Li J.-M.,
Zhou Z.-M.,
Sha J.-H.;
"Expression of a novel alternative transcript of the novel retinal pigment epithelial cell gene NORPEG in human testes.";
Asian J. Androl. 7:277-288(2005).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
TISSUE=Testis;
Sha J.H.,
Zhou Z.M.,
Li J.M.;
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
DOI=10.1093/dnares/7.1.65; PubMed=10718198 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T.,
Kikuno R.,
Ishikawa K.,
Hirosawa M.,
Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.";
DNA Res. 7:65-73(2000).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 636-980.
TISSUE=Brain;
The German cDNA consortium;
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
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[7]
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TISSUE SPECIFICITY.
PubMed=11168586 [NCBI, ExPASy, EBI, Israel, Japan]
Peng Y.-F.,
Mandai K.,
Sakisaka T.,
Okabe N.,
Yamamoto Y.,
Yokoyama S.,
Mizoguchi A.,
Shiozaki H.,
Monden M.,
Takai Y.;
"Ankycorbin: a novel actin cytoskeleton-associated protein.";
Genes Cells 5:1001-1008(2000).
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- INTERACTION:
P31946:YWHAB; NbExp=1; IntAct=EBI-1023749, EBI-359815;
P61981:YWHAG; NbExp=1; IntAct=EBI-1023749, EBI-359832;
P27348:YWHAQ; NbExp=1; IntAct=EBI-1023749, EBI-359854;
P63104:YWHAZ; NbExp=1; IntAct=EBI-1023749, EBI-347088;
- SUBCELLULAR LOCATION: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites and stress fibers (By similarity).
- ALTERNATIVE PRODUCTS:
3 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Synonyms | sNORPEG |
| Isoform ID | Q9P0K7-2 |
| Features which should be applied to build the isoform sequence: VSP_019248. |
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| Name | 3 |
| Isoform ID | Q9P0K7-3 |
| Features which should be applied to build the isoform sequence: VSP_019249. |
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- TISSUE SPECIFICITY: Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa.
- INDUCTION: Up-regulated by all-trans-retinoic acid in human retinal pigment epithelial cells (ARPE-19).
- MISCELLANEOUS: Doesn't bind directly to F-actin (By similarity).
- SIMILARITY: Contains 7 ANK repeats.
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