[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
TISSUE=Brain;
PubMed=9693107 [NCBI, ExPASy, EBI, Israel, Japan]
Sagane K.,
Ohya Y.,
Hasegawa Y.,
Tanaka I.;
"Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain.";
Biochem. J. 334:93-98(1998).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
PubMed=11050470 [NCBI, ExPASy, EBI, Israel, Japan]
Harada T.,
Nishie A.,
Torigoe K.,
Ikezaki K.,
Shono T.,
Maehara Y.,
Kuwano M.,
Wada M.;
"The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene in brain tissues and gliomas.";
Jpn. J. Cancer Res. 91:1001-1006(2000).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), AND VARIANT ARG-81.
TISSUE=Brain;
Wada M.,
Torigoe K.,
Harada T.,
Kuwano M.;
"Isolation and tissue specific expression of novel ADAM family from 7q21.1 region.";
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 40-906 (ISOFORM 1), AND VARIANT ARG-81.
TISSUE=Cerebellum;
DOI=10.1016/S0378-1119(99)00302-9; PubMed=10524237 [NCBI, ExPASy, EBI, Israel, Japan]
Poindexter K.,
Nelson N.,
DuBose R.F.,
Black R.A.,
Cerretti D.P.;
"The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries.";
Gene 237:61-70(1999).
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[5]
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FUNCTION, INTERACTION WITH YWHAZ, AND MUTAGENESIS OF SER-834 AND SER-857.
DOI=10.1016/S0006-291X(03)00056-1; PubMed=12589811 [NCBI, ExPASy, EBI, Israel, Japan]
Zhu P.,
Sun Y.,
Xu R.,
Sang Y.,
Zhao J.,
Liu G.,
Cai L.,
Li C.,
Zhao S.;
"The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading.";
Biochem. Biophys. Res. Commun. 301:991-999(2003).
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[6]
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SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
DOI=10.1186/gb-2004-5-2-r8; PubMed=14759258 [NCBI, ExPASy, EBI, Israel, Japan]
Hillman R.T.,
Green R.E.,
Brenner S.E.;
"An unappreciated role for RNA surveillance.";
Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
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[7]
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FUNCTION, INTERACTION WITH YWHAB, AND MUTAGENESIS OF SER-834 AND SER-857.
DOI=10.1016/j.bbrc.2005.03.229; PubMed=15882968 [NCBI, ExPASy, EBI, Israel, Japan]
Zhu P.,
Sang Y.,
Xu H.,
Zhao J.,
Xu R.,
Sun Y.,
Xu T.,
Wang X.,
Chen L.,
Feng H.,
Li C.,
Zhao S.;
"ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3.";
Biochem. Biophys. Res. Commun. 331:938-946(2005).
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[8]
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FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1227/01.NEU.0000192363.84287.8B; PubMed=16385342 [NCBI, ExPASy, EBI, Israel, Japan]
D'Abaco G.M.,
Ng K.,
Paradiso L.,
Godde N.J.,
Kaye A.,
Novak U.;
"ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain.";
Neurosurgery 58:179-186(2006).
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- FUNCTION: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation.
- SUBUNIT: Interacts through its C-terminal region with YWHAB/14-3-3 beta and YWHAZ/14-3-3 zeta but not with YWHAE/14-3-3 epsilon or YWHAH/14-3-3 eta.
- INTERACTION:
P31946:YWHAB; NbExp=1; IntAct=EBI-1567267, EBI-359815;
P31946:YWHAB; NbExp=2; IntAct=EBI-1567258, EBI-359815;
P62258:YWHAE; NbExp=1; IntAct=EBI-1567267, EBI-356498;
P61982:Ywhag (xeno); NbExp=1; IntAct=EBI-1567267, EBI-359843;
Q04917:YWHAH; NbExp=1; IntAct=EBI-1567267, EBI-306940;
P27348:YWHAQ; NbExp=2; IntAct=EBI-1567258, EBI-359854;
P27348:YWHAQ; NbExp=1; IntAct=EBI-1567267, EBI-359854;
P63104:YWHAZ; NbExp=2; IntAct=EBI-1567267, EBI-347088;
P63104:YWHAZ; NbExp=2; IntAct=EBI-1567258, EBI-347088;
- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
- ALTERNATIVE PRODUCTS:
5 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Synonyms | Delta |
| Isoform ID | Q9P0K1-2 |
| Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. |
| Features which should be applied to build the isoform sequence: VSP_005482, VSP_005484. |
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| Name | 3 |
| Synonyms | Alpha |
| Isoform ID | Q9P0K1-3 |
| Features which should be applied to build the isoform sequence: VSP_005483. |
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| Name | 5 |
| Isoform ID | Q9P0K1-5 |
| Features which should be applied to build the isoform sequence: VSP_005482. |
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- TISSUE SPECIFICITY: Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues.
- PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
- SIMILARITY: Contains 1 disintegrin domain.
- SIMILARITY: Contains 1 EGF-like domain.
- SIMILARITY: Contains 1 peptidase M12B domain [view classification].
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