ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q9P0G3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name KLK14_HUMAN
Primary accession number Q9P0G3
Secondary accession numbers None
Integrated into Swiss-Prot on January 11, 2001
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 70)
Name and origin of the protein
Protein name Kallikrein-14 [Precursor]
Synonyms EC 3.4.21.-
Kallikrein-like protein 6
KLK-L6
Gene name
Name: KLK14
Synonyms: KLKL6
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Yousef G.M., Diamandis E.P.;
"Molecular characterization, mapping, and tissue expression of KLKL6, a hormonally regulated kallikrein-like gene.";
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
DOI=10.1006/geno.2000.6490; PubMed=11352573 [NCBI, ExPASy, EBI, Israel, Japan]
Hooper J.D., Bui L.T., Rae F.K., Harvey T.J., Myers S.A., Ashworth L.K., Clements J.A.;
"Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle.";
Genomics 73:117-122(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02399; PubMed=15057824 [NCBI, ExPASy, EBI, Israel, Japan]
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[4]
TISSUE SPECIFICITY.
DOI=10.1074/jbc.M004525200; PubMed=10969073 [NCBI, ExPASy, EBI, Israel, Japan]
Harvey T.J., Hooper J.D., Myers S.A., Stephenson S.A., Ashworth L.K., Clements J.A.;
"Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.";
J. Biol. Chem. 275:37397-37406(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF161221; AAD50773.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF283669; AAK48523.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF283670; AAK48524.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC011473; AAG23260.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00000700; -.
UniGene Hs.283925
3D structure databases
HSSP P00760; 1EZX. [HSSP ENTRY / PDB]
ModBase Q9P0G3.
Protein family/group databases
MEROPS S01.029; -.
Organism-specific databases
GeneCards GC19M056272; -.
H-InvDB HIX0039986; -.
HGNC HGNC:6362; KLK14.
GenAtlas KLK14.
MIM 606135; gene. [NCBI / EBI]
PharmGKB PA30151; -.
Gene expression databases
ArrayExpress Q9P0G3; -.
Bgee Q9P0G3; -.
CleanEx HS_KLK14; -.
GermOnline ENSG00000129437; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004252; Molecular function: serine-type endopeptidase activity (non-traceable author statement from UniProtKB).
GO:0006508; Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR018114; Peptidase_S1/S6_AS.
IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9P0G3; -.
Genome annotation databases
Ensembl ENSG00000129437; Homo sapiens. [Contig view]
Phylogenomic databases
HOVERGEN Q9P0G3; -.
Other
PMAP-CutDB Q9P0G3; -.
SOURCE KLK14; Homo sapiens.
ProtoNet Q9P0G3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Disulfide bond; Hydrolase; Protease; Secreted; Serine protease; Signal; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     Potential. 
PROPEP   19    24  6     Activation peptide (Potential). PRO_0000027958
CHAIN   25   251  227     Kallikrein-14. PRO_0000027959
DOMAIN   25   249  225     Peptidase S1. 
ACT_SITE   67    67        Charge relay system (By similarity). 
ACT_SITE   111   111        Charge relay system (By similarity). 
ACT_SITE   204   204        Charge relay system (By similarity). 
DISULFID   31   164        By similarity. 
DISULFID   52    68        By similarity. 
DISULFID   143   210        By similarity. 
DISULFID   175   189        By similarity. 
DISULFID   200   225        By similarity. 
Sequence information
Length: 251 AA [This is the length of the unprocessed precursor] Molecular weight: 27453 Da [This is the MW of the unprocessed precursor] CRC64: 9087953BAFA7ED25 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFLLLTALQV LAIAMTQSQE DENKIIGGHT CTRSSQPWQA ALLAGPRRRF LCGGALLSGQ 

        70         80         90        100        110        120 
WVITAAHCGR PILQVALGKH NLRRWEATQQ VLRVVRQVTH PNYNSRTHDN DLMLLQLQQP 

       130        140        150        160        170        180 
ARIGRAVRPI EVTQACASPG TSCRVSGWGT ISSPIARYPA SLQCVNINIS PDEVCQKAYP 

       190        200        210        220        230        240 
RTITPGMVCA GVPQGGKDSC QGDSGGPLVC RGQLQGLVSW GMERCALPGY PGVYTNLCKY 

       250 
RSWIEETMRD K 

Q9P0G3 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!