[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1073/pnas.060027397; PubMed=10716726 [NCBI, ExPASy, EBI, Israel, Japan] Wu Q., Maniatis T.; "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes."; Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000).
[2]	NUCLEOTIDE SEQUENCE [MRNA] OF 1954-3312. TISSUE=Brain; DOI=10.1006/geno.1998.5341; PubMed=9693030 [NCBI, ExPASy, EBI, Israel, Japan] Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.; "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."; Genomics 51:27-34(1998).

Comments

FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation.
INTERACTION:
P00519:ABL1; NbExp=1; IntAct=EBI-308417, EBI-375543;
P06241:FYN; NbExp=1; IntAct=EBI-308417, EBI-515315;
P62993:GRB2; NbExp=1; IntAct=EBI-308417, EBI-401755;
P16333:NCK1; NbExp=1; IntAct=EBI-308417, EBI-389883;
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily [view classification].
SIMILARITY: Contains 9 cadherin domains.
SIMILARITY: Contains 8 EGF-like domains.
SIMILARITY: Contains 1 GPS domain.
SIMILARITY: Contains 1 laminin EGF-like domain.
SIMILARITY: Contains 2 laminin G-like domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF231023; AAF61929.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB011536; BAA32464.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

T00250; T00250.

NP_001398.2; -.

3D structure databases

HSSP

P01132; 1GK5. [HSSP ENTRY / PDB]

ModBase

Q9NYQ7.

Protein-protein interaction databases

IntAct

Q9NYQ7; -.

Protein family/group databases

GPCRDB

Q9NYQ7; CELR3_HUMAN.

PTM databases

PhosphoSite

Q9NYQ7; -.

Organism-specific databases

HIX0003291; -.

HGNC:3230; CELSR3.

604264; gene. [NCBI / EBI]

PA26395; -.

Gene expression databases

ArrayExpress

Q9NYQ7; -.

CleanEx

HS_CELSR3; -.

GermOnline

ENSG00000008300; Homo sapiens.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005509;	Molecular function: calcium ion binding (inferred from electronic annotation from InterPro).
GO:0004930;	Molecular function: G-protein coupled receptor activity (inferred from electronic annotation from InterPro).
GO:0007156;	Biological process: homophilic cell adhesion (inferred from electronic annotation from InterPro).
GO:0007275;	Biological process: multicellular organismal development (inferred from electronic annotation from UniProtKB-KW).
GO:0007218;	Biological process: neuropeptide signaling pathway (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR002126; Cadherin.
IPR013320; ConA_like_subgrp.
IPR006210; EGF.
IPR000152; EGF-type_Asp/Asn_hydroxyl_CS.
IPR000742; EGF_3.
IPR002049; EGF_laminin.
IPR006209; EGF_like.
IPR013032; EGF_like_reg_CS.
IPR001879; GPCR_2_extracellular.
IPR000832; GPCR_2_secretin-like.
IPR001791; Laminin_G.
IPR012680; Laminin_G_2.
IPR000203; PKD_cys_rich.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.60; Cadherin; 8.
G3DSA:2.60.120.200; ConA_like_subgrp; 2.

Pfam

PF00002; 7tm_2; 1.
PF00028; Cadherin; 9.
PF00008; EGF; 6.
PF01825; GPS; 1.
PF02793; HRM; 1.
PF00053; Laminin_EGF; 1.
PF02210; Laminin_G_2; 2.
Pfam graphical view of domain structure.

PRINTS

PR00205; CADHERIN.
PR00249; GPCRSECRETIN.

SMART

SM00112; CA; 9.
SM00181; EGF; 6.
SM00180; EGF_Lam; 1.
SM00303; GPS; 1.
SM00008; HormR; 1.
SM00282; LamG; 2.
SMART graphical view of domain structure.

PROSITE

PS00010; ASX_HYDROXYL; 1.
PS00232; CADHERIN_1; 7.
PS50268; CADHERIN_2; 8.
PS00022; EGF_1; 6.
PS01186; EGF_2; 4.
PS50026; EGF_3; 6.
PS01248; EGF_LAM_1; 1.
PS50027; EGF_LAM_2; 1.
PS00649; G_PROTEIN_RECEP_F2_1; FALSE_NEG.
PS00650; G_PROTEIN_RECEP_F2_2; 1.
PS50227; G_PROTEIN_RECEP_F2_3; 1.
PS50261; G_PROTEIN_RECEP_F2_4; 1.
PS50221; GPS; 1.
PS50025; LAM_G_DOMAIN; 2.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q9NYQ7.

Genome annotation databases

Ensembl

ENSG00000008300; Homo sapiens. [Contig view]

GeneID

1951; -.

KEGG

hsa:1951; -.

Phylogenomic databases

HOVERGEN

Q9NYQ7; -.

Other

LinkHub

Q9NYQ7; -.

NextBio

7907; -.

SOURCE

CELSR3; Homo sapiens.

GPCRDB-Snakes

Q9NYQ7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Calcium; Cell membrane; Developmental protein; EGF-like domain; G-protein coupled receptor; Glycoprotein; Hydroxylation; Laminin EGF-like domain; Membrane; Polymorphism; Receptor; Repeat; Signal; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 32`	`32`	`Potential.`
`CHAIN`	`33 3312`	`3280`	`Cadherin EGF LAG seven-pass G-type receptor 3.`	`PRO_0000012918`
`TOPO_DOM`	`33 2540`	`2508`	`Extracellular (Potential).`
`TRANSMEM`	`2541 2561`	`21`	`1 (Potential).`
`TOPO_DOM`	`2562 2572`	`11`	`Cytoplasmic (Potential).`
`TRANSMEM`	`2573 2593`	`21`	`2 (Potential).`
`TOPO_DOM`	`2594 2601`	`8`	`Extracellular (Potential).`
`TRANSMEM`	`2602 2622`	`21`	`3 (Potential).`
`TOPO_DOM`	`2623 2643`	`21`	`Cytoplasmic (Potential).`
`TRANSMEM`	`2644 2664`	`21`	`4 (Potential).`
`TOPO_DOM`	`2665 2681`	`17`	`Extracellular (Potential).`
`TRANSMEM`	`2682 2702`	`21`	`5 (Potential).`
`TOPO_DOM`	`2703 2725`	`23`	`Cytoplasmic (Potential).`
`TRANSMEM`	`2726 2746`	`21`	`6 (Potential).`
`TOPO_DOM`	`2747 2753`	`7`	`Extracellular (Potential).`
`TRANSMEM`	`2754 2774`	`21`	`7 (Potential).`
`TOPO_DOM`	`2775 3312`	`538`	`Cytoplasmic (Potential).`
`DOMAIN`	`326 433`	`108`	`Cadherin 1.`
`DOMAIN`	`434 545`	`112`	`Cadherin 2.`
`DOMAIN`	`546 651`	`106`	`Cadherin 3.`
`DOMAIN`	`652 756`	`105`	`Cadherin 4.`
`DOMAIN`	`757 858`	`102`	`Cadherin 5.`
`DOMAIN`	`859 961`	`103`	`Cadherin 6.`
`DOMAIN`	`962 1067`	`106`	`Cadherin 7.`
`DOMAIN`	`1068 1169`	`102`	`Cadherin 8.`
`DOMAIN`	`1170 1265`	`96`	`Cadherin 9.`
`DOMAIN`	`1375 1433`	`59`	`EGF-like 1; calcium-binding.`
`DOMAIN`	`1435 1471`	`37`	`EGF-like 2; calcium-binding.`
`DOMAIN`	`1475 1514`	`40`	`EGF-like 3; calcium-binding.`
`DOMAIN`	`1515 1719`	`205`	`Laminin G-like 1.`
`DOMAIN`	`1722 1758`	`37`	`EGF-like 4; calcium-binding.`
`DOMAIN`	`1764 1944`	`181`	`Laminin G-like 2.`
`DOMAIN`	`1946 1982`	`37`	`EGF-like 5; calcium-binding.`
`DOMAIN`	`1983 2020`	`38`	`EGF-like 6; calcium-binding.`
`DOMAIN`	`2021 2053`	`33`	`EGF-like 7; calcium-binding.`
`DOMAIN`	`2055 2090`	`36`	`EGF-like 8; calcium-binding.`
`DOMAIN`	`2077 2124`	`48`	`Laminin EGF-like.`
`DOMAIN`	`2477 2529`	`53`	`GPS.`
`MOD_RES`	`1963 1963`		`3-hydroxyaspartate (Potential).`
`CARBOHYD`	`632 632`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`847 847`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`1182 1182`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`1222 1222`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`1317 1317`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`1327 1327`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`1649 1649`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`1713 1713`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`1770 1770`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`2053 2053`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`2177 2177`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`2196 2196`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`2386 2386`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`2474 2474`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`2506 2506`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`1379 1390`		`By similarity.`
`DISULFID`	`1384 1421`		`By similarity.`
`DISULFID`	`1423 1432`		`By similarity.`
`DISULFID`	`1439 1450`		`By similarity.`
`DISULFID`	`1444 1459`		`By similarity.`
`DISULFID`	`1461 1470`		`By similarity.`
`DISULFID`	`1479 1490`		`By similarity.`
`DISULFID`	`1484 1500`		`By similarity.`
`DISULFID`	`1502 1513`		`By similarity.`
`DISULFID`	`1693 1719`		`By similarity.`
`DISULFID`	`1726 1737`		`By similarity.`
`DISULFID`	`1731 1746`		`By similarity.`
`DISULFID`	`1748 1757`		`By similarity.`
`DISULFID`	`1915 1944`		`By similarity.`
`DISULFID`	`1950 1961`		`By similarity.`
`DISULFID`	`1955 1970`		`By similarity.`
`DISULFID`	`1972 1981`		`By similarity.`
`DISULFID`	`1985 1996`		`By similarity.`
`DISULFID`	`1990 2008`		`By similarity.`
`DISULFID`	`2010 2019`		`By similarity.`
`DISULFID`	`2027 2040`		`By similarity.`
`DISULFID`	`2042 2052`		`By similarity.`
`DISULFID`	`2059 2074`		`By similarity.`
`DISULFID`	`2061 2077`		`By similarity.`
`DISULFID`	`2079 2089`		`By similarity.`
`DISULFID`	`2098 2107`		`By similarity.`
`DISULFID`	`2110 2122`		`By similarity.`
`VARIANT`	`157 157`	`1`	`A -> P (in dbSNP:rs3733085 [NCBI]).`	`VAR_020022`
`VARIANT`	`805 805`	`1`	`S -> T (in dbSNP:rs3821875 [NCBI]).`	`VAR_020023`
`CONFLICT`	`2158 2158`		`G -> GLRGAG (in Ref. 2).`

Sequence information

Length: 3312 AA [This is the length of the unprocessed precursor]

Molecular weight: 358257 Da [This is the MW of the unprocessed precursor]

CRC64: BEC208703651A4A5 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MMARRPPWRG LGERSTPILL LLLLSLFPLS QEELGGGGHQ GWDPGLAATT GPRAHIGGGA 

        70         80         90        100        110        120 
LALCPESSGV REDGGPGLGV REPIFVGLRG RRQSARNSRG PPEQPNEELG IEHGVQPLGS 

       130        140        150        160        170        180 
RERETGQGPG SVLYWRPEVS SCGRTGPLQR GSLSPGALSS GVPGSGNSSP LPSDFLIRHH 

       190        200        210        220        230        240 
GPKPVSSQRN AGTGSRKRVG TARCCGELWA TGSKGQGERA TTSGAERTAP RRNCLPGASG 

       250        260        270        280        290        300 
SGPELDSAPR TARTAPASGS APRESRTAPE PAPKRMRSRG LFRCRFLPQR PGPRPPGLPA 

       310        320        330        340        350        360 
RPEARKVTSA NRARFRRAAN RHPQFPQYNY QTLVPENEAA GTAVLRVVAQ DPDAGEAGRL 

       370        380        390        400        410        420 
VYSLAALMNS RSLELFSIDP QSGLIRTAAA LDRESMERHY LRVTAQDHGS PRLSATTMVA 

       430        440        450        460        470        480 
VTVADRNDHS PVFEQAQYRE TLRENVEEGY PILQLRATDG DAPPNANLRY RFVGPPAARA 

       490        500        510        520        530        540 
AAAAAFEIDP RSGLISTSGR VDREHMESYE LVVEASDQGQ EPGPRSATVR VHITVLDEND 

       550        560        570        580        590        600 
NAPQFSEKRY VAQVREDVRP HTVVLRVTAT DRDKDANGLV HYNIISGNSR GHFAIDSLTG 

       610        620        630        640        650        660 
EIQVVAPLDF EAEREYALRI RAQDAGRPPL SNNTGLASIQ VVDINDHIPI FVSTPFQVSV 

       670        680        690        700        710        720 
LENAPLGHSV IHIQAVDADH GENARLEYSL TGVAPDTPFV INSATGWVSV SGPLDRESVE 

       730        740        750        760        770        780 
HYFFGVEARD HGSPPLSASA SVTVTVLDVN DNRPEFTMKE YHLRLNEDAA VGTSVVSVTA 

       790        800        810        820        830        840 
VDRDANSAIS YQITGGNTRN RFAISTQGGV GLVTLALPLD YKQERYFKLV LTASDRALHD 

       850        860        870        880        890        900 
HCYVHINITD ANTHRPVFQS AHYSVSVNED RPMGSTIVVI SASDDDVGEN ARITYLLEDN 

       910        920        930        940        950        960 
LPQFRIDADS GAITLQAPLD YEDQVTYTLA ITARDNGIPQ KADTTYVEVM VNDVNDNAPQ 

       970        980        990       1000       1010       1020 
FVASHYTGLV SEDAPPFTSV LQISATDRDA HANGRVQYTF QNGEDGDGDF TIEPTSGIVR 

      1030       1040       1050       1060       1070       1080 
TVRRLDREAV SVYELTAYAV DRGVPPLRTP VSIQVMVQDV NDNAPVFPAE EFEVRVKENS 

      1090       1100       1110       1120       1130       1140 
IVGSVVAQIT AVDPDEGPNA HIMYQIVEGN IPELFQMDIF SGELTALIDL DYEARQEYVI 

      1150       1160       1170       1180       1190       1200 
VVQATSAPLV SRATVHVRLV DQNDNSPVLN NFQILFNNYV SNRSDTFPSG IIGRIPAYDP 

      1210       1220       1230       1240       1250       1260 
DVSDHLFYSF ERGNELQLLV VNQTSGELRL SRKLDNNRPL VASMLVTVTD GLHSVTAQCV 

      1270       1280       1290       1300       1310       1320 
LRVVIITEEL LANSLTVRLE NMWQERFLSP LLGRFLEGVA AVLATPAEDV FIFNIQNDTD 

      1330       1340       1350       1360       1370       1380 
VGGTVLNVSF SALAPRGAGA GAAGPWFSSE ELQEQLYVRR AALAARSLLD VLPFDDNVCL 

      1390       1400       1410       1420       1430       1440 
REPCENYMKC VSVLRFDSSA PFLASASTLF RPIQPIAGLR CRCPPGFTGD FCETELDLCY 

      1450       1460       1470       1480       1490       1500 
SNPCRNGGAC ARREGGYTCV CRPRFTGEDC ELDTEAGRCV PGVCRNGGTC TDAPNGGFRC 

      1510       1520       1530       1540       1550       1560 
QCPAGGAFEG PRCEVAARSF PPSSFVMFRG LRQRFHLTLS LSFATVQQSG LLFYNGRLNE 

      1570       1580       1590       1600       1610       1620 
KHDFLALELV AGQVRLTYST GESNTVVSPT VPGGLSDGQW HTVHLRYYNK PRTDALGGAQ 

      1630       1640       1650       1660       1670       1680 
GPSKDKVAVL SVDDCDVAVA LQFGAEIGNY SCAAAGVQTS SKKSLDLTGP LLLGGVPNLP 

      1690       1700       1710       1720       1730       1740 
ENFPVSHKDF IGCMRDLHID GRRVDMAAFV ANNGTMAGCQ AKLHFCDSGP CKNSGFCSER 

      1750       1760       1770       1780       1790       1800 
WGSFSCDCPV GFGGKDCQLT MAHPHHFRGN GTLSWNFGSD MAVSVPWYLG LAFRTRATQG 

      1810       1820       1830       1840       1850       1860 
VLMQVQAGPH STLLCQLDRG LLSVTVTRGS GRASHLLLDQ VTVSDGRWHD LRLELQEEPG 

      1870       1880       1890       1900       1910       1920 
GRRGHHVLMV SLDFSLFQDT MAVGSELQGL KVKQLHVGGL PPGSAEEAPQ GLVGCIQGVW 

      1930       1940       1950       1960       1970       1980 
LGSTPSGSPA LLPPSHRVNA EPGCVVTNAC ASGPCPPHAD CRDLWQTFSC TCQPGYYGPG 

      1990       2000       2010       2020       2030       2040 
CVDACLLNPC QNQGSCRHLP GAPHGYTCDC VGGYFGHHCE HRMDQQCPRG WWGSPTCGPC 

      2050       2060       2070       2080       2090       2100 
NCDVHKGFDP NCNKTNGQCH CKEFHYRPRG SDSCLPCDCY PVGSTSRSCA PHSGQCPCRP 

      2110       2120       2130       2140       2150       2160 
GALGRQCNSC DSPFAEVTAS GCRVLYDACP KSLRSGVWWP QTKFGVLATV PCPRGALGAA 

      2170       2180       2190       2200       2210       2220 
VRLCDEAQGW LEPDLFNCTS PAFRELSLLL DGLELNKTAL DTMEAKKLAQ RLREVTGHTD 

      2230       2240       2250       2260       2270       2280 
HYFSQDVRVT ARLLAHLLAF ESHQQGFGLT ATQDAHFNEN LLWAGSALLA PETGDLWAAL 

      2290       2300       2310       2320       2330       2340 
GQRAPGGSPG SAGLVRHLEE YAATLARNME LTYLNPMGLV TPNIMLSIDR MEHPSSPRGA 

      2350       2360       2370       2380       2390       2400 
RRYPRYHSNL FRGQDAWDPH THVLLPSQSP RPSPSEVLPT SSSIENSTTS SVVPPPAPPE 

      2410       2420       2430       2440       2450       2460 
PEPGISIIIL LVYRTLGGLL PAQFQAERRG ARLPQNPVMN SPVVSVAVFH GRNFLRGILE 

      2470       2480       2490       2500       2510       2520 
SPISLEFRLL QTANRSKAIC VQWDPPGLAE QHGVWTARDC ELVHRNGSHA RCRCSRTGTF 

      2530       2540       2550       2560       2570       2580 
GVLMDASPRE RLEGDLELLA VFTHVVVAVS VAALVLTAAI LLSLRSLKSN VRGIHANVAA 

      2590       2600       2610       2620       2630       2640 
ALGVAELLFL LGIHRTHNQL VCTAVAILLH YFFLSTFAWL FVQGLHLYRM QVEPRNVDRG 

      2650       2660       2670       2680       2690       2700 
AMRFYHALGW GVPAVLLGLA VGLDPEGYGN PDFCWISVHE PLIWSFAGPV VLVIVMNGTM 

      2710       2720       2730       2740       2750       2760 
FLLAARTSCS TGQREAKKTS ALTLRSSFLL LLLVSASWLF GLLAVNHSIL AFHYLHAGLC 

      2770       2780       2790       2800       2810       2820 
GLQGLAVLLL FCVLNADARA AWMPACLGRK AAPEEARPAP GLGPGAYNNT ALFEESGLIR 

      2830       2840       2850       2860       2870       2880 
ITLGASTVSS VSSARSGRTQ DQDSQRGRSY LRDNVLVRHG SAADHTDHSL QAHAGPTDLD 

      2890       2900       2910       2920       2930       2940 
VAMFHRDAGA DSDSDSDLSL EEERSLSIPS SESEDNGRTR GRFQRPLCRA AQSERLLTHP 

      2950       2960       2970       2980       2990       3000 
KDVDGNDLLS YWPALGECEA APCALQTWGS ERRLGLDTSK DAANNNQPDP ALTSGDETSL 

      3010       3020       3030       3040       3050       3060 
GRAQRQRKGI LKNRLQYPLV PQTRGAPELS WCRAATLGHR AVPAASYGRI YAGGGTGSLS 

      3070       3080       3090       3100       3110       3120 
QPASRYSSRE QLDLLLRRQL SRERLEEAPA PVLRPLSRPG SQECMDAAPG RLEPKDRGST 

      3130       3