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UniProtKB/Swiss-Prot entry Q9NYL4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FKB11_HUMAN
Primary accession number Q9NYL4
Secondary accession numbers None
Integrated into Swiss-Prot on September 19, 2002
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 51)
Name and origin of the protein
Protein name FK506-binding protein 11 [Precursor]
Synonyms EC 5.2.1.8
Peptidyl-prolyl cis-trans isomerase
PPIase
Rotamase
19 kDa FK506-binding protein
FKBP-19
Gene name
Name: FKBP11
Synonyms: FKBP19
ORFNames: UNQ336/PRO535
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Rulten S., Kay J.E., Robinson C.;
"Identification of novel FKBP genes.";
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas, and Spleen;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF238079; AAF63478.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358998; AAQ89357.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC027973; AAH27973.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_057678.1; -.
UniGene Hs.655103
3D structure databases
HSSP Q00688; 1PBK. [HSSP ENTRY / PDB]
ModBase Q9NYL4.
Organism-specific databases
H-InvDB HIX0010591; -.
HGNC HGNC:18624; FKBP11.
GenAtlas FKBP11.
MIM 610571; gene. [NCBI / EBI]
PharmGKB PA38607; -.
GeneCards Q9NYL4.
Gene expression databases
ArrayExpress Q9NYL4; -.
CleanEx HS_FKBP11; -.
GermOnline ENSG00000134285; Homo sapiens.
Family and domain databases
InterPro IPR001179; PPIase_FKBP.
Graphical view of domain structure.
PANTHER PTHR10516; PPIase_FKBP; 1.
Pfam PF00254; FKBP_C; 1.
Pfam graphical view of domain structure.
PROSITE PS50059; FKBP_PPIASE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9NYL4.
Genome annotation databases
Ensembl ENSG00000134285; Homo sapiens. [Contig view]
GeneID 51303; -.
KEGG hsa:51303; -.
Phylogenomic databases
HOGENOM Q9NYL4; -.
HOVERGEN Q9NYL4; -.
Other
SOURCE FKBP11; Homo sapiens.
ProtoNet Q9NYL4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Isomerase; Membrane; Rotamase; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    27  27     Potential. 
CHAIN   28   201  174     FK506-binding protein 11. PRO_0000025519
TRANSMEM   156   176  21     Potential. 
DOMAIN   57   144  88     PPIase FKBP-type. 
Sequence information
Length: 201 AA [This is the length of the unprocessed precursor] Molecular weight: 22180 Da [This is the MW of the unprocessed precursor] CRC64: 586E430B9D2DC0A2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTLRPSLLPL HLLLLLLLSA AVCRAEAGLE TESPVRTLQV ETLVEPPEPC AEPAAFGDTL 

        70         80         90        100        110        120 
HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL LDMCVGEKRR AIIPSHLAYG 

       130        140        150        160        170        180 
KRGFPPSVPA DAVVQYDVEL IALIRANYWL KLVKGILPLV GMAMVPALLG LIGYHLYRKA 

       190        200 
NRPKVSKKKL KEEKRNKSKK K 

Q9NYL4 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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