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UniProtKB/Swiss-Prot entry Q9NWZ5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UCKL1_HUMAN
Primary accession number Q9NWZ5
Secondary accession numbers Q5JWV0 Q70AQ5 Q8N524 Q9H3Z2
Integrated into Swiss-Prot on May 2, 2002
Sequence was last modified on September 13, 2005 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name Uridine/cytidine kinase-like 1
Synonym EC 2.7.1.48
Gene name
Name: UCKL1
Synonyms: URKL1
ORFNames: F538
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH EBV EBNA3, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND FUNCTION.
TISSUE=Heart;
DOI=10.1186/1471-2121-3-23; PubMed=12199906 [NCBI, ExPASy, EBI, Israel, Japan]
Kashuba E., Kashuba V., Sandalova T., Klein G., Szekely L.;
"Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase.";
BMC Cell Biol. 3:23-23(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Spleen;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
INTERACTION WITH RNF19B, AND UBIQUITINATION.
PubMed=16709802 [NCBI, ExPASy, EBI, Israel, Japan]
Fortier J.M., Kornbluth J.;
"NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase.";
J. Immunol. 176:6454-6463(2006).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ605558; CAE54074.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK000524; BAA91230.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK223220; BAD96940.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL118506; CAI21904.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033078; AAH33078.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_060329.2; -.
UniGene Hs.504998
3D structure databases
HSSP Q26998; 1JLS. [HSSP ENTRY / PDB]
ModBase Q9NWZ5.
PTM databases
PhosphoSite Q9NWZ5; -.
Organism-specific databases
HGNC HGNC:15938; UCKL1.
GenAtlas UCKL1.
HPA HPA004722; -.
HPA004769; -.
MIM 610866; gene. [NCBI / EBI]
PharmGKB PA38058; -.
GeneCards Q9NWZ5.
Gene expression databases
ArrayExpress Q9NWZ5; -.
CleanEx HS_UCKL1; -.
GermOnline ENSG00000198276; Homo sapiens.
Ontologies
GO
GO:0005783; Cellular component: endoplasmic reticulum (inferred from direct assay from HPA).
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0016773; Molecular function: phosphotransferase activity, alcohol group as acceptor (inferred from electronic annotation from InterPro).
GO:0004849; Molecular function: uridine kinase activity (inferred from electronic annotation from EC).
GO:0044419; Biological process: interspecies interaction between organisms (inferred from electronic annotation from UniProtKB-KW).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006083; PRK_URK.
IPR000764; Uridine_kin.
Graphical view of domain structure.
PANTHER PTHR10285:SF6; Uridine_kin; 1.
Pfam PF00485; PRK; 1.
Pfam graphical view of domain structure.
PRINTS PR00988; URIDINKINASE.
TIGRFAMs TIGR00235; udk; 1.
ProtoNet Q9NWZ5.
Genome annotation databases
Ensembl ENSG00000198276; Homo sapiens. [Contig view]
GeneID 54963; -.
KEGG hsa:54963; -.
Phylogenomic databases
HOVERGEN Q9NWZ5; -.
Other
NextBio 58176; -.
SOURCE UCKL1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Cytoplasm; Host-virus interaction; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Transferase; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   548  548     Uridine/cytidine kinase-like 1. PRO_0000164460
NP_BIND   105   112  8     ATP (Potential). 
MOD_RES   16    16        Phosphoserine. 
MOD_RES   107   107        Phosphoserine (By similarity). 
VAR_SEQ   303   548        RELSVRAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRD KETSRDEFIFYSKRLMRLLIEHALSFLPFQDCVVQTPQGQ DYAGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIGTI LIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAA MMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVR IITTAVDKRVNDLFRIIPGIGNFGDRYFGTDAVPDGSDEE EVAYTG -> GCAGLGTPVPPAAPDAERPEEHAAGTGHAHHHQVRAHLGT GRPRARAPAQLLAPQGQGDQSRRVHLLLQETDAAAHRARA LLPALSGLRRTDPAGAGLCGQVLCGEADHRCVHSARR (in isoform 2). VSP_021802
VAR_SEQ   386   395        GKCYAGKQIT -> DHRCVHSARR (in isoform 3). VSP_025641
VAR_SEQ   396   548        Missing (in isoform 3). VSP_025642
CONFLICT   290   290        D -> N (in Ref. 1; CAE54074 and 2; BAA91230). 
Sequence information
Length: 548 AA [This is the length of the unprocessed precursor] Molecular weight: 61141 Da [This is the MW of the unprocessed precursor] CRC64: 0CD0351A802FE199 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAPPARADA DPSPTSPPTA RDTPGRQAEK SETACEDRSN AESLDRLLPP VGTGRSPRKR 

        70         80         90        100        110        120 
TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA IGLGGGSASG KTTVARMIIE 

       130        140        150        160        170        180 
ALDVPWVVLL SMDSFYKVLT EQQQEQAAHN NFNFDHPDAF DFDLIISTLK KLKQGKSVKV 

       190        200        210        220        230        240 
PIYDFTTHSR KKDWKTLYGA NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR 

       250        260        270        280        290        300 
DISERGRDIE GVIKQYNKFV KPSFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL 

       310        320        330        340        350        360 
EERELSVRAA LASAHQCHPL PRTLSVLKST PQVRGMHTII RDKETSRDEF IFYSKRLMRL 

       370        380        390        400        410        420 
LIEHALSFLP FQDCVVQTPQ GQDYAGKCYA GKQITGVSIL RAGETMEPAL RAVCKDVRIG 

       430        440        450        460        470        480 
TILIQTNQLT GEPELHYLRL PKDISDDHVI LMDCTVSTGA AAMMAVRVLL DHDVPEDKIF 

       490        500        510        520        530        540 
LLSLLMAEMG VHSVAYAFPR VRIITTAVDK RVNDLFRIIP GIGNFGDRYF GTDAVPDGSD 


EEEVAYTG 

Q9NWZ5 in FASTA format

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