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UniProtKB/Swiss-Prot entry Q9NWM8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FKB14_HUMAN
Primary accession number Q9NWM8
Secondary accession numbers None
Integrated into Swiss-Prot on October 10, 2002
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 65)
Name and origin of the protein
Protein name FK506-binding protein 14 [Precursor]
Synonyms EC 5.2.1.8
Peptidyl-prolyl cis-trans isomerase
PPIase
Rotamase
22 kDa FK506-binding protein
FKBP-22
Gene name
Name: FKBP14
Synonyms: FKBP22
ORFNames: UNQ322/PRO381
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEIN SEQUENCE OF 20-34.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY358643; AAQ89006.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK000738; BAA91351.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC005206; AAH05206.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_060416.1; -.
UniGene Hs.571333
3D structure databases
HSSP P18203; 1FKL. [HSSP ENTRY / PDB]
ModBase Q9NWM8.
Organism-specific databases
H-InvDB HIX0006561; -.
HGNC HGNC:18625; FKBP14.
GenAtlas FKBP14.
HPA HPA013329; -.
PharmGKB PA38608; -.
GeneCards Q9NWM8.
Gene expression databases
ArrayExpress Q9NWM8; -.
CleanEx HS_FKBP14; -.
GermOnline ENSG00000106080; Homo sapiens.
Ontologies
GO
GO:0005788; Cellular component: endoplasmic reticulum lumen (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002048; EF_hand_Ca_bd.
IPR000886; ER_targeting_sequence.
IPR001179; PPIase_FKBP.
Graphical view of domain structure.
PANTHER PTHR10516; PPIase_FKBP; 1.
Pfam PF00036; efhand; 2.
PF00254; FKBP_C; 1.
Pfam graphical view of domain structure.
SMART SM00054; EFh; 2.
SMART graphical view of domain structure.
PROSITE PS00018; EF_HAND_1; 1.
PS50222; EF_HAND_2; 2.
PS00014; ER_TARGET; 1.
PS50059; FKBP_PPIASE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9NWM8.
Genome annotation databases
Ensembl ENSG00000106080; Homo sapiens. [Contig view]
GeneID 55033; -.
KEGG hsa:55033; -.
Phylogenomic databases
HOGENOM Q9NWM8; -.
HOVERGEN Q9NWM8; -.
Other
ProtoNet Q9NWM8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Isomerase; Repeat; Rotamase; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19      
CHAIN   20   211  192     FK506-binding protein 14. PRO_0000025521
DOMAIN   45   135  91     PPIase FKBP-type. 
DOMAIN   135   170  36     EF-hand 1. 
DOMAIN   179   211  33     EF-hand 2. 
CA_BIND   148   159  12     1 (Potential). 
CA_BIND   192   203  12     2 (Potential). 
MOTIF   208   211  4     Prevents secretion from ER (Potential). 
CARBOHYD   176   176        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 211 AA [This is the length of the unprocessed precursor] Molecular weight: 24172 Da [This is the MW of the unprocessed precursor] CRC64: 858184954FE10029 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRLFLWNAVL TLFVTSLIGA LIPEPEVKIE VLQKPFICHR KTKGGDLMLV HYEGYLEKDG 

        70         80         90        100        110        120 
SLFHSTHKHN NGQPIWFTLG ILEALKGWDQ GLKGMCVGEK RKLIIPPALG YGKEGKGKIP 

       130        140        150        160        170        180 
PESTLIFNID LLEIRNGPRS HESFQEMDLN DDWKLSKDEV KAYLKKEFEK HGAVVNESHH 

       190        200        210 
DALVEDIFDK EDEDKDGFIS AREFTYKHDE L 

Q9NWM8 in FASTA format

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