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UniProtKB/Swiss-Prot entry Q9NVR2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name INT10_HUMAN
Primary accession number Q9NVR2
Secondary accession numbers Q6IA93 Q7L538 Q7L8C8 Q9H3W8
Integrated into Swiss-Prot on May 16, 2006
Sequence was last modified on May 16, 2006 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 57)
Name and origin of the protein
Protein name Integrator complex subunit 10
Synonym Int10
Gene name
Name: INTS10
Synonyms: C8orf35
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Teratocarcinoma;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-710.
TISSUE=Lung, and Neuroblastoma;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-710.
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 377-710.
TISSUE=Lymph node;
DOI=10.1186/1471-2164-8-399; PubMed=17974005 [NCBI, ExPASy, EBI, Israel, Japan]
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[5]
IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX, AND SUBCELLULAR LOCATION.
DOI=10.1016/j.cell.2005.08.019; PubMed=16239144 [NCBI, ExPASy, EBI, Israel, Japan]
Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.;
"Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.";
Cell 123:265-276(2005).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
Comments
  • FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
  • SUBUNIT: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with POLR2A.
  • INTERACTION:
    P04049:RAF1; NbExp=2; IntAct=EBI-536703, EBI-365996;
  • SUBCELLULAR LOCATION: Nucleus.
  • SIMILARITY: Belongs to the Integrator subunit 10 family.
  • SEQUENCE CAUTION:
    • Sequence=BAA91687.1; Type=Frameshift; Positions=90;
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK001431; BAA91687.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001915; AAH01915.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC006209; AAH06209.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC051282; AAH51282.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR457262; CAG33543.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL442078; CAC09444.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BK005727; DAA05727.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00550272; -.
RefSeq NP_060612.2; -.
UniGene Hs.512627
3D structure databases
ModBase Q9NVR2.
Protein-protein interaction databases
IntAct Q9NVR2; 1.
PTM databases
PhosphoSite Q9NVR2; -.
Organism-specific databases
GeneCards GC08P019721; -.
HGNC HGNC:25548; INTS10.
GenAtlas INTS10.
MIM 611353; gene. [NCBI / EBI]
Gene expression databases
ArrayExpress Q9NVR2; -.
Bgee Q9NVR2; -.
CleanEx HS_INTS10; -.
GermOnline ENSG00000104613; Homo sapiens.
Ontologies
GO
GO:0032039; Cellular component: integrator complex (inferred from direct assay from HGNC).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0016180; Biological process: snRNA processing (inferred from direct assay from HGNC).
QuickGo view.
Proteomic databases
PRIDE Q9NVR2; -.
Genome annotation databases
Ensembl ENSG00000104613; Homo sapiens. [Contig view]
GeneID 55174; -.
KEGG hsa:55174; -.
Phylogenomic databases
HOGENOM Q9NVR2; -.
HOVERGEN Q9NVR2; -.
OMA Q9NVR2; DDEDCSA.
Other
NextBio 58967; -.
SOURCE INTS10; Homo sapiens.
ProtoNet Q9NVR2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Nucleus; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   710  710     Integrator complex subunit 10. PRO_0000235687
COMPBIAS   132   136  5     Poly-Leu. 
MOD_RES   231   231        Phosphoserine. 
CONFLICT   412   412        S -> N (in Ref. 3; CAG33543). 
Sequence information
Length: 710 AA [This is the length of the unprocessed precursor] Molecular weight: 82236 Da [This is the MW of the unprocessed precursor] CRC64: 3E9945064EC4BEFB [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSAQGDCEFL VQRARELVPQ DLWAAKAWLI TARSLYPADF NIQYEMYTIE RNAERTATAG 

        70         80         90        100        110        120 
RLLYDMFVNF PDQPVVWREI SIITSALRND SQDKQTQFLR SLFETLPGRV QCEMLLKVTE 

       130        140        150        160        170        180 
QCFNTLERSE MLLLLLRRFP ETVVQHGVGL GEALLEAETI EEQESPVNCF RKLFVCDVLP 

       190        200        210        220        230        240 
LIINNHDVRL PANLLYKYLN KAAEFYINYV TRSTQIENQH QGAQDTSDLM SPSKRSSQKY 

       250        260        270        280        290        300 
IIEGLTEKSS QIVDPWERLF KILNVVGMRC EWQMDKGRRS YGDILHRMKD LCRYMNNFDS 

       310        320        330        340        350        360 
EAHAKYKNQV VYSTMLVFFK NAFQYVNSIQ PSLFQGPNAP SQVPLVLLED VSNVYGDVEI 

       370        380        390        400        410        420 
DRNKHIHKKR KLAEGREKTM SSDDEDCSAK GRNRHIVVNK AELANSTEVL ESFKLARESW 

       430        440        450        460        470        480 
ELLYSLEFLD KEFTRICLAW KTDTWLWLRI FLTDMIIYQG QYKKAIASLH HLAALQGSIS 

       490        500        510        520        530        540 
QPQITGQGTL EHQRALIQLA TCHFALGEYR MTCEKVLDLM CYMVLPIQDG GKSQEEPSKV 

       550        560        570        580        590        600 
KPKFRKGSDL KLLPCTSKAI MPYCLHLMLA CFKLRAFTDN RDDMALGHVI VLLQQEWPRG 

       610        620        630        640        650        660 
ENLFLKAVNK ICQQGNFQYE NFFNYVTNID MLEEFAYLRT QEGGKIHLEL LPNQGMLIKH 

       670        680        690        700        710 
HTVTRGITKG VKEDFRLAME RQVSRCGENL MVVLHRFCIN EKILLLQTLT 

Q9NVR2 in FASTA format

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