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UniProtKB/Swiss-Prot entry Q9NTI2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AT8A2_HUMAN
Primary accession number Q9NTI2
Secondary accession numbers Q9H527 Q9NPU6 Q9NTL2 Q9NYM3
Integrated into Swiss-Prot on October 18, 2001
Sequence was last modified on April 30, 2003 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 68)
Name and origin of the protein
Protein name Probable phospholipid-transporting ATPase IB
Synonyms EC 3.6.3.1
ATPase class I type 8A member 2
ML-1
Gene name
Name: ATP8A2
Synonyms: ATPIB
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE (ISOFORM 2).
Sun X.L., Milo G.E., Li D.;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02379; PubMed=15057823 [NCBI, ExPASy, EBI, Israel, Japan]
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
"The DNA sequence and analysis of human chromosome 13.";
Nature 428:522-528(2004).
[3]
PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10551800 [NCBI, ExPASy, EBI, Israel, Japan]
Sun X.L., Li D., Fang J., Noyes I., Casto B., Theil K., Shuler C., Milo G.E.;
"Changes in levels of normal ML-1 gene transcripts associated with the conversion of human nontumorigenic to tumorigenic phenotypes.";
Gene Expr. 8:129-139(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-1148 (ISOFORM 1).
TISSUE=Testis;
The German cDNA consortium;
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-1148 (ISOFORM 1).
TISSUE=Amygdala;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 928-1148.
TISSUE=Amygdala;
The German cDNA consortium;
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF236871; AAF40215.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138815; CAH70513.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136438; CAH70513.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138958; CAH70513.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL157366; CAH70513.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356316; CAH70513.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL669971; CAH70513.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138958; CAH71291.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136438; CAH71291.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138815; CAH71291.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL157366; CAH71291.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356316; CAH71291.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL669971; CAH71291.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL157366; CAH74073.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136438; CAH74073.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138815; CAH74073.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138958; CAH74073.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356316; CAH74073.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL669971; CAH74073.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356316; CAH70876.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136438; CAH70876.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138815; CAH70876.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138958; CAH70876.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL157366; CAH70876.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL669971; CAH70876.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL669971; CAH73647.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136438; CAH73647.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138815; CAH73647.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138958; CAH73647.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL157366; CAH73647.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356316; CAH73647.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136438; CAH70146.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138815; CAH70146.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL138958; CAH70146.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL157366; CAH70146.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL356316; CAH70146.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL669971; CAH70146.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX537836; CAD97848.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL137256; CAB70658.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK094653; BAC04396.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL390129; CAB99084.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T46328; T46328.
T51867; T51867.
UniGene Hs.444957
3D structure databases
ModBase Q9NTI2.
PTM databases
PhosphoSite Q9NTI2; -.
Organism-specific databases
HGNC HGNC:13533; ATP8A2.
GenAtlas ATP8A2.
MIM 605870; gene. [NCBI / EBI]
PharmGKB PA25166; -.
GeneCards Q9NTI2.
Gene expression databases
ArrayExpress Q9NTI2; -.
CleanEx HS_ATP8A2; -.
GermOnline ENSG00000132932; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0015662; Molecular function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from InterPro).
GO:0004012; Molecular function: phospholipid-translocating ATPase activity (inferred from electronic annotation from InterPro).
GO:0008285; Biological process: negative regulation of cell proliferation (traceable author statement from ProtInc).
GO:0015914; Biological process: phospholipid transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001757; ATPase_P.
IPR008250; E1-E2_ATPase_reg.
IPR006539; Flippase.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00122; E1-E2_ATPase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
TIGRFAMs TIGR01652; ATPase-Plipid; 1.
TIGR01494; ATPase_P-type; 4.
PROSITE PS00154; ATPASE_E1_E2; 1.
ProtoNet Q9NTI2.
Genome annotation databases
Ensembl ENSG00000132932; Homo sapiens. [Contig view]
Phylogenomic databases
HOVERGEN Q9NTI2; -.
Other
LinkHub Q9NTI2; -.
SOURCE ATP8A2; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Hydrolase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1148  1148     Probable phospholipid-transporting ATPase IB. PRO_0000046362
TOPO_DOM   1     44  44     Cytoplasmic (Potential). 
TRANSMEM   45     66  22     Potential. 
TOPO_DOM   67     71  5     Extracellular (Potential). 
TRANSMEM   72     94  23     Potential. 
TOPO_DOM   95    276  182     Cytoplasmic (Potential). 
TRANSMEM   277    298  22     Potential. 
TOPO_DOM   299    323  25     Extracellular (Potential). 
TRANSMEM   324    345  22     Potential. 
TOPO_DOM   346    837  492     Cytoplasmic (Potential). 
TRANSMEM   838    858  21     Potential. 
TOPO_DOM   859    870  12     Extracellular (Potential). 
TRANSMEM   871    890  20     Potential. 
TOPO_DOM   891    920  30     Cytoplasmic (Potential). 
TRANSMEM   921    942  22     Potential. 
TOPO_DOM   943    956  14     Extracellular (Potential). 
TRANSMEM   957    979  23     Potential. 
TOPO_DOM   980    985  6     Cytoplasmic (Potential). 
TRANSMEM   986   1006  21     Potential. 
TOPO_DOM   1007   1024  18     Extracellular (Potential). 
TRANSMEM   1025   1049  25     Potential. 
TOPO_DOM   1050   1148  99     Cytoplasmic (Potential). 
ACT_SITE   388    388        4-aspartylphosphate intermediate (By similarity). 
METAL   781    781        Magnesium (By similarity). 
METAL   785    785        Magnesium (By similarity). 
MOD_RES   5      5        Phosphothreonine (By similarity). 
VAR_SEQ   515    543        MGQEQTFGILNVLEFSSDRKRMSVIVRTP -> VSNMRVHFRSPAFVKIVCVKWHVYCKYDQ (in isoform 2). VSP_008038
VAR_SEQ   544    697        Missing (in isoform 2). VSP_008039
CONFLICT   949    950        LT -> FD (in Ref. 1 and 5). 
Sequence information
Length: 1148 AA [This is the length of the unprocessed precursor] Molecular weight: 129242 Da [This is the MW of the unprocessed precursor] CRC64: E9F363B568C7EE82 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSRATSVGDQ LEAPARTIYL NQPHLNKFRD NQISTAKYSV LTFLPRFLYE QIRRAANAFF 

        70         80         90        100        110        120 
LFIALLQQIP DVSPTGRYTT LVPLIIILTI AGIKEIVEDF KRHKADNAVN KKKTIVLRNG 

       130        140        150        160        170        180 
MWHTIMWKEV AVGDIVKVVN GQYLPADVVL LSSSEPQAMC YVETANLDGE TNLKIRQGLS 

       190        200        210        220        230        240 
HTADMQTREV LMKLSGTIEC EGPNRHLYDF TGNLNLDGKS LVALGPDQIL LRGTQLRNTQ 

       250        260        270        280        290        300 
WVFGIVVYTG HDTKLMQNST KAPLKRSNVE KVTNVQILVL FGILLVMALV SSAGALYWNR 

       310        320        330        340        350        360 
SHGEKNWYIK KMDTTSDNFG YNLLTFIILY NNLIPISLLV TLEVVKYTQA LFINWDTDMY 

       370        380        390        400        410        420 
YIGNDTPAMA RTSNLNEELG QVKYLFSDKT GTLTCNIMNF KKCSIAGVTY GHFPELAREP 

       430        440        450        460        470        480 
SSDDFCRMPP PCSDSCDFDD PRLLKNIEDR HPTAPCIQEF LTLLAVCHTV VPEKDGDNII 

       490        500        510        520        530        540 
YQASSPDEAA LVKGAKKLGF VFTARTPFSV IIEAMGQEQT FGILNVLEFS SDRKRMSVIV 

       550        560        570        580        590        600 
RTPSGRLRLY CKGADNVIFE RLSKDSKYME ETLCHLEYFA TEGLRTLCVA YADLSENEYE 

       610        620        630        640        650        660 
EWLKVYQEAS TILKDRAQRL EECYEIIEKN LLLLGATAIE DRLQAGVPET IATLLKAEIK 

       670        680        690        700        710        720 
IWVLTGDKQE TAINIGYSCR LVSQNMALIL LKEDSLDATR AAITQHCTDL GNLLGKENDV 

       730        740        750        760        770        780 
ALIIDGHTLK YALSFEVRRS FLDLALSCKA VICCRVSPLQ KSEIVDVVKK RVKAITLAIG 

       790        800        810        820        830        840 
DGANDVGMIQ TAHVGVGISG NEGMQATNNS DYAIAQFSYL EKLLLVHGAW SYNRVTKCIL 

       850        860        870        880        890        900 
YCFYKNVVLY IIELWFAFVN GFSGQILFER WCIGLYNVIF TALPPFTLGI FERSCTQESM 

       910        920        930        940        950        960 
LRFPQLYKIT QNGEGFNTKV FWGHCINALV HSLILFWFPM KALEHDTVLT SGHATDYLFV 

       970        980        990       1000       1010       1020 
GNIVYTYVVV TVCLKAGLET TAWTKFSHLA VWGSMLTWLV FFGIYSTIWP TIPIAPDMRG 

      1030       1040       1050       1060       1070       1080 
QATMVLSSAH FWLGLFLVPT ACLIEDVAWR AAKHTCKKTL LEEVQELETK SRVLGKAVLR 

      1090       1100       1110       1120       1130       1140 
DSNGKRLNER DRLIKRLGRK TPPTLFRGSS LQQGVPHGYA FSQEEHGAVS QEEVIRAYDT 


TKKKSRKK 

Q9NTI2 in FASTA format

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