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UniProtKB/Swiss-Prot entry Q9NSK0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KLC4_HUMAN
Primary accession number Q9NSK0
Secondary accession number Q66K28
Integrated into Swiss-Prot on April 27, 2001
Sequence was last modified on October 17, 2006 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 67)
Name and origin of the protein
Protein name Kinesin light chain 4
Synonyms KLC 4
Kinesin-like protein 8
Gene name
Name: KLC4
Synonyms: KNSL8
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Brain, and Small intestine;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Amygdala, and Oesophageal carcinoma;
The German cDNA consortium;
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Prostate, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74; SER-83; SER-93 AND SER-100, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-590, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460 AND SER-590, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK127018; BAC86788.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK127894; BAC87179.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL162078; CAB82411.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL355385; CAI13781.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC080637; AAH80637.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC103727; AAI03728.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX640717; CAE45836.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T47147; T47147.
RefSeq NP_958929.1; -.
NP_958930.1; -.
UniGene Hs.655123
3D structure databases
ModBase Q9NSK0.
Protein-protein interaction databases
IntAct Q9NSK0; -.
PTM databases
PhosphoSite Q9NSK0; -.
Organism-specific databases
HGNC HGNC:21624; KLC4.
GenAtlas KLC4.
PharmGKB PA134934134; -.
GeneCards Q9NSK0.
Gene expression databases
ArrayExpress Q9NSK0; -.
CleanEx HS_KLC4; -.
GermOnline ENSG00000137171; Homo sapiens.
Ontologies
GO
GO:0005871; Cellular component: kinesin complex (inferred from electronic annotation from InterPro).
GO:0005874; Cellular component: microtubule (inferred from electronic annotation from UniProtKB-KW).
GO:0003777; Molecular function: microtubule motor activity (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR002151; Kinesin_light.
IPR015792; Kinesin_light_repeat.
IPR015390; Rabaptin_Rab5-bd.
IPR001440; TPR-1.
IPR011990; TPR-like_helical.
IPR013105; TPR_2.
IPR013026; TPR_region.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.10; TPR-like_helical; 1.
Pfam PF09311; Rab5-bind; 1.
PF00515; TPR_1; 3.
PF07719; TPR_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00381; KINESINLIGHT.
SMART SM00028; TPR; 4.
SMART graphical view of domain structure.
PROSITE PS01160; KINESIN_LIGHT; 3.
PS50005; TPR; 6.
PS50293; TPR_REGION; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q9NSK0.
Genome annotation databases
Ensembl ENSG00000137171; Homo sapiens. [Contig view]
GeneID 89953; -.
Phylogenomic databases
HOGENOM Q9NSK0; -.
HOVERGEN Q9NSK0; -.
Other
NextBio 76452; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Coiled coil; Microtubule; Motor protein; Phosphoprotein; Repeat; TPR repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   619  619     Kinesin light chain 4. PRO_0000215097
REPEAT   55    88  34     TPR 1. 
REPEAT   211   244  34     TPR 2. 
REPEAT   253   286  34     TPR 3. 
REPEAT   295   328  34     TPR 4. 
REPEAT   337   370  34     TPR 5. 
REPEAT   379   412  34     TPR 6. 
REPEAT   464   497  34     TPR 7. 
COILED   32   150  119     Potential. 
MOD_RES   74    74        Phosphoserine. 
MOD_RES   83    83        Phosphoserine. 
MOD_RES   93    93        Phosphoserine. 
MOD_RES   100   100        Phosphoserine. 
MOD_RES   174   174        Phosphoserine (By similarity). 
MOD_RES   460   460        Phosphoserine. 
MOD_RES   566   566        Phosphoserine (By similarity). 
MOD_RES   590   590        Phosphoserine. 
VAR_SEQ   1    87        Missing (in isoform 2). VSP_021012
VAR_SEQ   419   422        DDHK -> EPAP (in isoform 2). VSP_021013
VAR_SEQ   423   619        Missing (in isoform 2). VSP_021014
CONFLICT   54    54        L -> LQTIECL (in Ref. 1; BAC87179). 
Sequence information
Length: 619 AA [This is the length of the unprocessed precursor] Molecular weight: 68640 Da [This is the MW of the unprocessed precursor] CRC64: 32DFC2A9A91B5574 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLEALRSEH QAVLQSLSQT IECLQQGGHE 

        70         80         90        100        110        120 
EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES EKQKLRAQVR RLCQENQWLR 

       130        140        150        160        170        180 
DELAGTQQRL QRSEQAVAQL EEEKKHLEFL GQLRQYDEDG HTSEEKEGDA TKDSLDDLFP 

       190        200        210        220        230        240 
NEEEEDPSNG LSRGQGATAA QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED 

       250        260        270        280        290        300 
LERTSGRGHP DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGPD HPAVAATLNN 

       310        320        330        340        350        360 
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TNHPDVAKQL NNLALLCQNQ GKYEAVERYY 

       370        380        390        400        410        420 
QRALAIYEGQ LGPDNPNVAR TKNNLASCYL KQGKYAEAET LYKEILTRAH VQEFGSVDDD 

       430        440        450        460        470        480 
HKPIWMHAEE REEMSKSRHH EGGTPYAEYG GWYKACKVSS PTVNTTLRNL GALYRRQGKL 

       490        500        510        520        530        540 
EAAETLEECA LRSRRQGTDP ISQTKVAELL GESDGRRTSQ EGPGDSVKFE GGEDASVAVE 

       550        560        570        580        590        600 
WSGDGSGTLQ RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSNMKRAAS LNYLNQPSAA 

       610 
PLQVSRGLSA STMDLSSSS 

Q9NSK0 in FASTA format

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