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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Frontal cortex;
DOI=10.1016/S0896-6273(00)80588-7; PubMed=9808458 [NCBI, ExPASy, EBI, Israel, Japan]
Xiao B.,
Tu J.C.,
Petralia R.S.,
Yuan J.P.,
Doan A.,
Breder C.D.,
Ruggiero A.,
Lanahan A.A.,
Wenthold R.J.,
Worley P.F.;
"Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.";
Neuron 21:707-716(1998).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
DOI=10.1006/jmbi.1999.3436; PubMed=10653696 [NCBI, ExPASy, EBI, Israel, Japan]
Soloviev M.,
Ciruela F.,
Chan W.-Y.,
McIlhinney R.A.J.;
"Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing.";
J. Mol. Biol. 295:1185-1200(2000).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Brain;
Yoshida M.,
Ueno M.,
Nakamura H.,
Saya H.;
"Mammalian neuralized interacts with a novel protein which has a EVH1-like domain.";
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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INTERACTION WITH GRM1; GRM5; DYN3 AND ITPR1.
DOI=10.1016/S0896-6273(00)80589-9; PubMed=9808459 [NCBI, ExPASy, EBI, Israel, Japan]
Tu J.C.,
Xiao B.,
Yuan J.P.,
Lanahan A.A.,
Leoffert K.,
Li M.,
Linden D.J.,
Worley P.F.;
"Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.";
Neuron 21:717-726(1998).
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- FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with CENTG1. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
- SUBUNIT: Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.
- SUBCELLULAR LOCATION: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
- ALTERNATIVE PRODUCTS:
4 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Synonyms | 2a |
| Isoform ID | Q9NSB8-2 |
| Features which should be applied to build the isoform sequence: VSP_009069. |
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| Name | 3 |
| Synonyms | 2d |
| Isoform ID | Q9NSB8-3 |
| Features which should be applied to build the isoform sequence: VSP_009070. |
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- DOMAIN: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.
- SIMILARITY: Belongs to the Homer family.
- SIMILARITY: Contains 1 WH1 domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 354 AA [This is the length of the unprocessed precursor] |
Molecular weight: 40627 Da [This is the MW of the unprocessed precursor] |
CRC64: 33D258177F798373 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGEQPIFTTR AHVFQIDPNT KKNWMPASKQ AVTVSYFYDV TRNSYRIISV DGAKVIINST
70 80 90 100 110 120
ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSEQQLTKFA EKFQEVKEAA KIAKDKTQEK
130 140 150 160 170 180
IETSSNHSQE SGRETPSSTQ ASSVNGTDDE KASHAGPANT HLKSENDKLK IALTQSAANV
190 200 210 220 230 240
KKWEIELQTL RESNARLTTA LQESAASVEQ WKRQFSICRD ENDRLRNKID ELEEQCSEIN
250 260 270 280 290 300
REKEKNTQLK RRIEELEAEL REKETELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN
310 320 330 340 350
LEDKVRSLKT DIEESKYRQR HLKVELKSFL EVLDGKIDDL HDFRRGLSKL GTDN
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Q9NSB8 in FASTA format |
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