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UniProtKB/Swiss-Prot entry Q9NRG4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SMYD2_HUMAN
Primary accession number Q9NRG4
Secondary accession numbers Q4V765 Q5VSH9
Integrated into Swiss-Prot on May 10, 2004
Sequence was last modified on September 13, 2005 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name SET and MYND domain-containing protein 2
Synonyms HSKM-B
Lysine N-methyltransferase 3C
Gene name
Name: SMYD2
Synonyms: KMT3C
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-165.
TISSUE=Liver cancer;
Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.;
"A novel gene expressed in human liver cancer tissue.";
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-165.
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF226053; AAF86953.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929236; CAH70920.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC098276; AAH98276.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC098133; AAH98133.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC098335; AAH98335.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_064582.2; -.
UniGene Hs.66170
3D structure databases
ModBase Q9NRG4.
Protein-protein interaction databases
IntAct Q9NRG4; -.
PTM databases
PhosphoSite Q9NRG4; -.
Organism-specific databases
HGNC HGNC:20982; SMYD2.
GenAtlas SMYD2.
MIM 610663; gene. [NCBI / EBI]
PharmGKB PA134930268; -.
GeneCards Q9NRG4.
Gene expression databases
ArrayExpress Q9NRG4; -.
CleanEx HS_SMYD2; -.
GermOnline ENSG00000143499; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR001214; SET.
IPR002893; Znf_MYND.
Graphical view of domain structure.
Pfam PF01753; zf-MYND; 1.
Pfam graphical view of domain structure.
SMART SM00317; SET; 1.
SMART graphical view of domain structure.
PROSITE PS50280; SET; 1.
PS01360; ZF_MYND_1; 1.
PS50865; ZF_MYND_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9NRG4.
Genome annotation databases
Ensembl ENSG00000143499; Homo sapiens. [Contig view]
GeneID 56950; -.
KEGG hsa:56950; -.
Phylogenomic databases
HOGENOM Q9NRG4; -.
HOVERGEN Q9NRG4; -.
Other
SOURCE SMYD2; Homo sapiens.
ProtoNet Q9NRG4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Metal-binding; Polymorphism; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   433  433     SET and MYND domain-containing protein 2. PRO_0000218309
DOMAIN   127   247  121     SET. 
ZN_FING   52    90  39     MYND-type. 
VARIANT   165   165  1     G -> E (in dbSNP:rs1134647 [NCBI]). VAR_023442 
Sequence information
Length: 433 AA [This is the length of the unprocessed precursor] Molecular weight: 49688 Da [This is the MW of the unprocessed precursor] CRC64: 3EEA5B8417870F5D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRAEGLGGLE RFCSPGKGRG LRALQPFQVG DLLFSCPAYA YVLTVNERGN HCEYCFTRKE 

        70         80         90        100        110        120 
GLSKCGRCKQ AFYCNVECQK EDWPMHKLEC SPMVVFGENW NPSETVRLTA RILAKQKIHP 

       130        140        150        160        170        180 
ERTPSEKLLA VKEFESHLDK LDNEKKDLIQ SDIAALHHFY SKHLGFPDND SLVVLFAQVN 

       190        200        210        220        230        240 
CNGFTIEDEE LSHLGSAIFP DVALMNHSCC PNVIVTYKGT LAEVRAVQEI KPGEEVFTSY 

       250        260        270        280        290        300 
IDLLYPTEDR NDRLRDSYFF TCECQECTTK DKDKAKVEIR KLSDPPKAEA IRDMVRYARN 

       310        320        330        340        350        360 
VIEEFRRAKH YKSPSELLEI CELSQEKMSS VFEDSNVYML HMMYQAMGVC LYMQDWEGAL 

       370        380        390        400        410        420 
QYGQKIIKPY SKHYPLYSLN VASMWLKLGR LYMGLEHKAA GEKALKKAIA IMEVAHGKDH 

       430 
PYISEIKQEI ESH 

Q9NRG4 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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