[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/S0378-1119(03)00721-2; PubMed=14557071 [NCBI, ExPASy, EBI, Israel, Japan]
Choi M.S.,
Anderson M.A.,
Zhang Z.,
Zimonjic D.B.,
Popescu N.,
Mukherjee A.B.;
"Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.";
Gene 315:113-122(2003).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
DOI=10.1074/jbc.M503002200; PubMed=15946935 [NCBI, ExPASy, EBI, Israel, Japan]
Osawa Y.,
Uchinami H.,
Bielawski J.,
Schwabe R.F.,
Hannun Y.A.,
Brenner D.A.;
"Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.";
J. Biol. Chem. 280:27879-27887(2005).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02462; PubMed=15164054 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P.,
Earthrowl M.E.,
Grafham D.V.,
Rubenfield M.,
French L.,
Steward C.A.,
Sims S.K.,
Jones M.C.,
Searle S.,
Scott C.,
Howe K.,
Hunt S.E.,
Andrews T.D.,
Gilbert J.G.R.,
Swarbreck D.,
Ashurst J.L.,
Taylor A.,
Battles J.,
Bird C.P., ![]()
Ainscough R.,
Almeida J.P.,
Ashwell R.I.S.,
Ambrose K.D.,
Babbage A.K.,
Bagguley C.L.,
Bailey J.,
Banerjee R.,
Bates K.,
Beasley H.,
Bray-Allen S.,
Brown A.J.,
Brown J.Y.,
Burford D.C.,
Burrill W.,
Burton J.,
Cahill P.,
Camire D.,
Carter N.P.,
Chapman J.C.,
Clark S.Y.,
Clarke G.,
Clee C.M.,
Clegg S.,
Corby N.,
Coulson A.,
Dhami P.,
Dutta I.,
Dunn M.,
Faulkner L.,
Frankish A.,
Frankland J.A.,
Garner P.,
Garnett J.,
Gribble S.,
Griffiths C.,
Grocock R.,
Gustafson E.,
Hammond S.,
Harley J.L.,
Hart E.,
Heath P.D.,
Ho T.P.,
Hopkins B.,
Horne J.,
Howden P.J.,
Huckle E.,
Hynds C.,
Johnson C.,
Johnson D.,
Kana A.,
Kay M.,
Kimberley A.M.,
Kershaw J.K.,
Kokkinaki M.,
Laird G.K.,
Lawlor S.,
Lee H.M.,
Leongamornlert D.A.,
Laird G.,
Lloyd C.,
Lloyd D.M.,
Loveland J.,
Lovell J.,
McLaren S.,
McLay K.E.,
McMurray A.,
Mashreghi-Mohammadi M.,
Matthews L.,
Milne S.,
Nickerson T.,
Nguyen M.,
Overton-Larty E.,
Palmer S.A.,
Pearce A.V.,
Peck A.I.,
Pelan S.,
Phillimore B.,
Porter K.,
Rice C.M.,
Rogosin A.,
Ross M.T.,
Sarafidou T.,
Sehra H.K.,
Shownkeen R.,
Skuce C.D.,
Smith M.,
Standring L.,
Sycamore N.,
Tester J.,
Thorpe A.,
Torcasso W.,
Tracey A.,
Tromans A.,
Tsolas J.,
Wall M.,
Walsh J.,
Wang H.,
Weinstock K.,
West A.P.,
Willey D.L.,
Whitehead S.L.,
Wilming L.,
Wray P.W.,
Young L.,
Chen Y.,
Lovering R.C.,
Moschonas N.K.,
Siebert R.,
Fechtel K.,
Bentley D.,
Durbin R.M.,
Hubbard T.,
Doucette-Stamm L.,
Beck S.,
Smith D.R.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 20-780 (ISOFORM 1), ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, POSSIBLE SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1074/jbc.M002522200; PubMed=10781606 [NCBI, ExPASy, EBI, Israel, Japan]
El Bawab S.,
Roddy P.,
Qian T.,
Bielawska A.,
Lemasters J.J.,
Hannun Y.A.;
"Molecular cloning and characterization of a human mitochondrial ceramidase.";
J. Biol. Chem. 275:21508-21513(2000).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-780 (ISOFORM 2).
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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SUBCELLULAR LOCATION, AND GLYCOSYLATION.
DOI=10.1016/j.bbrc.2005.03.134; PubMed=15845354 [NCBI, ExPASy, EBI, Israel, Japan]
Hwang Y.H.,
Tani M.,
Nakagawa T.,
Okino N.,
Ito M.;
"Subcellular localization of human neutral ceramidase expressed in HEK293 cells.";
Biochem. Biophys. Res. Commun. 331:37-42(2005).
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[7]
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FUNCTION.
DOI=10.1194/jlr.M500268-JLR200; PubMed=16061940 [NCBI, ExPASy, EBI, Israel, Japan]
Tani M.,
Sano T.,
Ito M.,
Igarashi Y.;
"Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.";
J. Lipid Res. 46:2458-2467(2005).
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[8]
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ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ACTIVE SITE, AND MUTAGENESIS OF SER-258; ASP-352; SER-354; CYS-362; SER-374; SER-396; SER-595 AND SER-729.
DOI=10.1042/BJ20050682; PubMed=16229686 [NCBI, ExPASy, EBI, Israel, Japan]
Galadari S.,
Wu B.X.,
Mao C.,
Roddy P.,
El Bawab S.,
Hannun Y.A.;
"Identification of a novel amidase motif in neutral ceramidase.";
Biochem. J. 393:687-695(2006).
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[9]
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TISSUE SPECIFICITY.
DOI=10.1007/s10048-007-0081-5; PubMed=17334805 [NCBI, ExPASy, EBI, Israel, Japan]
Avramopoulos D.,
Wang R.,
Valle D.,
Fallin M.D.,
Bassett S.S.;
"A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease.";
Neurogenetics 8:111-120(2007).
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