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UniProtKB/Swiss-Prot entry Q9NQX5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NPDC1_HUMAN
Primary accession number Q9NQX5
Secondary accession numbers Q5SPY8 Q9BTD6 Q9BXT3 Q9NQS2 Q9Y434
Integrated into Swiss-Prot on January 11, 2001
Sequence was last modified on August 13, 2002 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 69)
Name and origin of the protein
Protein name Neural proliferation differentiation and control protein 1 [Precursor]
Synonym NPDC-1
Gene name
Name: NPDC1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Iris;
Wistow G.J.;
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fetal liver;
DOI=10.1016/S0378-1119(01)00324-9; PubMed=11245976 [NCBI, ExPASy, EBI, Israel, Japan]
Qu X., Zhang C., Zhai Y., Xing G., Wei H., Yu Y., Wu S., He F.;
"Characterization and tissue expression of a novel human gene npdc1.";
Gene 264:37-44(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02465; PubMed=15164053 [NCBI, ExPASy, EBI, Israel, Japan]
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 39-325.
TISSUE=Brain;
Evrard C., Apiou F., Dutrillaux B., Rouget P.;
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-325.
TISSUE=Uterus;
DOI=10.1186/1471-2164-8-399; PubMed=17974005 [NCBI, ExPASy, EBI, Israel, Japan]
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF272357; AAF76225.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF285836; AAK27328.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL807752; CAI12775.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC004217; AAH04217.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF283247; AAF82603.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL050221; CAB43321.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00299699; -.
PIR T08809; T08809.
RefSeq NP_056207.3; -.
UniGene Hs.105547
3D structure databases
ModBase Q9NQX5.
Protein-protein interaction databases
IntAct Q9NQX5; 4.
PTM databases
PhosphoSite Q9NQX5; -.
Organism-specific databases
GeneCards GC09M139053; -.
HGNC HGNC:7899; NPDC1.
GenAtlas NPDC1.
HPA HPA008189; -.
MIM 605798; gene. [NCBI / EBI]
PharmGKB PA31701; -.
Gene expression databases
ArrayExpress Q9NQX5; -.
Bgee Q9NQX5; -.
CleanEx HS_NPDC1; -.
GermOnline ENSG00000107281; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR009635; NPDC1.
Graphical view of domain structure.
PANTHER PTHR23352; NPDC1; 1.
Pfam PF06809; NPDC1; 1.
Pfam graphical view of domain structure.
Proteomic databases
PeptideAtlas Q9NQX5; -.
PRIDE Q9NQX5; -.
Genome annotation databases
Ensembl ENSG00000107281; Homo sapiens. [Contig view]
GeneID 56654; -.
KEGG hsa:56654; -.
Phylogenomic databases
HOVERGEN Q9NQX5; -.
OMA Q9NQX5; PCLQSFQ.
Other
NextBio 62117; -.
SOURCE NPDC1; Homo sapiens.
ProtoNet Q9NQX5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Membrane; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    34  34     Potential. 
CHAIN   35   325  291     Neural proliferation differentiation and control protein 1. PRO_0000021830
TRANSMEM   182   202  21     Potential. 
COMPBIAS   145   167  23     Pro/Ser/Thr-rich. 
COMPBIAS   227   237  11     Pro/Ser/Thr-rich. 
CONFLICT   113   113        H -> Q (in Ref. 1; AAF76225). 
CONFLICT   159   159        L -> M (in Ref. 2; AAK27328). 
CONFLICT   210   210        Q -> H (in Ref. 2; AAK27328). 
CONFLICT   218   226        KADYATAKA -> EGRLRHCEG (in Ref. 6; CAB43321). 
CONFLICT   289   289        E -> D (in Ref. 5; AAF82603). 
Sequence information
Length: 325 AA [This is the length of the unprocessed precursor] Molecular weight: 34516 Da [This is the MW of the unprocessed precursor] CRC64: 21D6512AD345A575 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL KRRARCPPGA 

        70         80         90        100        110        120 
HACGPCLQPF QEDQQGLCVP RMRRPPGGGR PQPRLEDEID FLAQELARKE SGHSTPPLPK 

       130        140        150        160        170        180 
DRQRLPEPAT LGFSARGQGL ELGLPSTPGT PTPTPHTSLG SPVSSDPVHM SPLEPRGGQG 

       190        200        210        220        230        240 
DGLALVLILA FCVAGAAALS VASLCWCRLQ REIRLTQKAD YATAKAPGSP AAPRISPGDQ 

       250        260        270        280        290        300 
RLAQSAEMYH YQHQRQQMLC LERHKEPPKE LDTASSDEEN EDGDFTVYEC PGLAPTGEME 

       310        320 
VRNPLFDHAA LSAPLPAPSS PPALP 

Q9NQX5 in FASTA format

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