[1]	NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. PubMed=11404393 [NCBI, ExPASy, EBI, Israel, Japan] Yousefi S., Cooper P.R., Potter S.L., Mueck B., Jarai G.; "Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes."; J. Leukoc. Biol. 69:1045-1052(2001).
[2]	NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. DOI=10.1006/jmbi.2001.4520; PubMed=11273702 [NCBI, ExPASy, EBI, Israel, Japan] Wittenberger T., Schaller H.C., Hellebrand S.; "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."; J. Mol. Biol. 307:799-813(2001).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1016/S0014-5793(02)02775-8; PubMed=12044878 [NCBI, ExPASy, EBI, Israel, Japan] Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; "Identification of G protein-coupled receptor genes from the human genome sequence."; FEBS Lett. 520:97-101(2002).
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta, intestine, bone marrow, lung and peripheral blood leukocytes. Within leukocyte population more abundant expression in neutrophils and eosinophils, in comparison with that in T- or B-lymphocytes.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF282693; AAF91467.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF237762; AAK01857.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB083586; BAB89299.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC020614; AAH20614.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00006903; -.

NP_065103.1; -.

3D structure databases

ModBase

Q9NQS5.

Protein family/group databases

GPCRDB

Q9NQS5; GPR84_HUMAN.

Organism-specific databases

GC12M053042; -.

HGNC:4535; GPR84.

606383; gene. [NCBI / EBI]

PharmGKB

PA28928; -.

Gene expression databases

Q9NQS5; -.

Q9NQS5; -.

HS_GPR84; -.

ENSG00000139572; Homo sapiens.

Ontologies

GO:0016021;	Cellular component: integral to membrane (non-traceable author statement from UniProtKB).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004930;	Molecular function: G-protein coupled receptor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00237; GPCRRHODOPSN.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q9NQS5; -.

Genome annotation databases

Ensembl

ENSG00000139572; Homo sapiens. [Contig view]

GeneID

53831; -.

KEGG

hsa:53831; -.

Phylogenomic databases

HOGENOM

Q9NQS5; -.

HOVERGEN

Q9NQS5; -.

OMA

Q9NQS5; ADLLYCT.

Other

56158; -.

GPR84; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 396`	`396`	`Probable G-protein coupled receptor 84.`	`PRO_0000069589`
`TOPO_DOM`	`1 26`	`26`	`Extracellular (Potential).`
`TRANSMEM`	`27 47`	`21`	`1 (Potential).`
`TOPO_DOM`	`48 57`	`10`	`Cytoplasmic (Potential).`
`TRANSMEM`	`58 78`	`21`	`2 (Potential).`
`TOPO_DOM`	`79 94`	`16`	`Extracellular (Potential).`
`TRANSMEM`	`95 115`	`21`	`3 (Potential).`
`TOPO_DOM`	`116 144`	`29`	`Cytoplasmic (Potential).`
`TRANSMEM`	`145 165`	`21`	`4 (Potential).`
`TOPO_DOM`	`166 180`	`15`	`Extracellular (Potential).`
`TRANSMEM`	`181 201`	`21`	`5 (Potential).`
`TOPO_DOM`	`202 320`	`119`	`Cytoplasmic (Potential).`
`TRANSMEM`	`321 341`	`21`	`6 (Potential).`
`TOPO_DOM`	`342 352`	`11`	`Extracellular (Potential).`
`TRANSMEM`	`353 373`	`21`	`7 (Potential).`
`TOPO_DOM`	`374 396`	`23`	`Cytoplasmic (Potential).`
`MOD_RES`	`221 221`		`Phosphoserine (By similarity).`
`MOD_RES`	`224 224`		`Phosphoserine (By similarity).`
`MOD_RES`	`391 391`		`Phosphoserine (By similarity).`
`CARBOHYD`	`3 3`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`8 8`		`N-linked (GlcNAc...) (Potential).`
`VARIANT`	`37 37`	`1`	`G -> D (in dbSNP:rs11170883 [NCBI]).`	`VAR_049397`

Sequence information

Length: 396 AA [This is the length of the unprocessed precursor]

Molecular weight: 43705 Da [This is the MW of the unprocessed precursor]

CRC64: BEEA467DFEB7520B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MWNSSDANFS CYHESVLGYR YVAVSWGVVV AVTGTVGNVL TLLALAIQPK LRTRFNLLIA 

        70         80         90        100        110        120 
NLTLADLLYC TLLQPFSVDT YLHLHWRTGA TFCRVFGLLL FASNSVSILT LCLIALGRYL 

       130        140        150        160        170        180 
LIAHPKLFPQ VFSAKGIVLA LVSTWVVGVA SFAPLWPIYI LVPVVCTCSF DRIRGRPYTT 

       190        200        210        220        230        240 
ILMGIYFVLG LSSVGIFYCL IHRQVKRAAQ ALDQYKLRQA SIHSNHVART DEAMPGRFQE 

       250        260        270        280        290        300 
LDSRLASGGP SEGISSEPVS AATTQTLEGD SSEVGDQINS KRAKQMAEKS PPEASAKAQP 

       310        320        330        340        350        360 
IKGARRAPDS SSEFGKVTRM CFAVFLCFAL SYIPFLLLNI LDARVQAPRV VHMLAANLTW 

       370        380        390 
LNGCINPVLY AAMNRQFRQA YGSILKRGPR SFHRLH

Q9NQS5 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools