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UniProtKB/Swiss-Prot entry Q9NQ29


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LUC7L_HUMAN
Primary accession number Q9NQ29
Secondary accession numbers Q96S32 Q9NPH4
Integrated into Swiss-Prot on May 10, 2004
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 50)
Name and origin of the protein
Protein name Putative RNA-binding protein Luc7-like 1
Synonyms SR+89
Putative SR protein LUC7B1
Gene name
Name: LUC7L
Synonyms: LUC7L1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE (ISOFORM 2).
Utsch B., Albers N., Wickert L., Bidlingmaier F., Ludwig M.;
"SR+89, a gene encoding a serine/arginine-rich protein, is widely transcribed from human chromosome 16p13.3 proximal to the alpha-globin cluster. Exclusion of this new gene as a candidate gene for the hypospadic phenotype associated with homozygous SEA-alpha-thalassaemia.";
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1006/geno.2000.6394; PubMed=11170747 [NCBI, ExPASy, EBI, Israel, Japan]
Tufarelli C., Frischauf A.-M., Hardison R., Flint J., Higgs D.R.;
"Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain.";
Genomics 71:307-314(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/hmg/10.4.339; PubMed=11157797 [NCBI, ExPASy, EBI, Israel, Japan]
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.";
Hum. Mol. Genet. 10:339-352(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Embryo;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
TISSUE=Blood, and Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ404326; CAB93981.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ404326; CAB93982.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY005111; AAG22846.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE006462; AAK61218.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK001093; BAA91500.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC003194; AAH03194.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC065198; AAH65198.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_060502.1; -.
NP_958815.1; -.
UniGene Hs.16803
3D structure databases
ModBase Q9NQ29.
Protein-protein interaction databases
IntAct Q9NQ29; -.
PTM databases
PhosphoSite Q9NQ29; -.
Organism-specific databases
HGNC HGNC:6723; LUC7L.
GenAtlas LUC7L.
MIM 607782; gene. [NCBI / EBI]
PharmGKB PA30485; -.
GeneCards Q9NQ29.
Gene expression databases
ArrayExpress Q9NQ29; -.
CleanEx HS_LUC7L; -.
GermOnline ENSG00000007392; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR004882; LUC7_rel.
Graphical view of domain structure.
PANTHER PTHR12375; LUC7_rel; 1.
Pfam PF03194; LUC7; 1.
Pfam graphical view of domain structure.
ProtoNet Q9NQ29.
Genome annotation databases
Ensembl ENSG00000007392; Homo sapiens. [Contig view]
GeneID 55692; -.
KEGG hsa:55692; -.
Phylogenomic databases
HOGENOM Q9NQ29; -.
HOVERGEN Q9NQ29; -.
Other
NextBio 60505; -.
SOURCE LUC7L; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Coiled coil; Metal-binding; Phosphoprotein; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   371  371     Putative RNA-binding protein Luc7-like 1. PRO_0000187280
ZN_FING   188   215  28     C2H2-type; atypical. 
COILED   87   177  91     Potential. 
COILED   218   259  42     Potential. 
COMPBIAS   243   362  120     Arg/Ser-rich. 
MOD_RES   363   363        Phosphoserine. 
VAR_SEQ   1    20        MSAQAQMRALLDQLMGTARD -> MQM (in isoform 3). VSP_010214
VAR_SEQ   326   371        Missing (in isoform 2). VSP_010215
CONFLICT   171   171        E -> V (in Ref. 3; AAK61218). 
Sequence information
Length: 371 AA [This is the length of the unprocessed precursor] Molecular weight: 43728 Da [This is the MW of the unprocessed precursor] CRC64: C277F424F5F5659C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSAQAQMRAL LDQLMGTARD GDETRQRVKF TDDRVCKSHL LDCCPHDILA GTRMDLGECT 

        70         80         90        100        110        120 
KIHDLALRAD YEIASKERDL FFELDAMDHL ESFIAECDRR TELAKKRLAE TQEEISAEVS 

       130        140        150        160        170        180 
AKAEKVHELN EEIGKLLAKA EQLGAEGNVD ESQKILMEVE KVRAKKKEAE EEYRNSMPAS 

       190        200        210        220        230        240 
SFQQQKLRVC EVCSAYLGLH DNDRRLADHF GGKLHLGFIQ IREKLDQLRK TVAEKQEKRN 

       250        260        270        280        290        300 
QDRLRRREER EREERLSRRS GSRTRDRRRS RSRDRRRRRS RSTSRERRKL SRSRSRDRHR 

       310        320        330        340        350        360 
RHRSRSRSHS RGHRRASRDR SAKYKFSRER ASREESWESG RSERGPPDWR LESSNGKMAS 

       370 
RRSEEKEAGE I 

Q9NQ29 in FASTA format

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