[1]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IL12B, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1016/S1074-7613(00)00070-4; PubMed=11114383 [NCBI, ExPASy, EBI, Israel, Japan]
Oppmann B.,
Lesley R.,
Blom B.,
Timans J.C.,
Xu Y.,
Hunte B.,
Vega F.,
Yu N.,
Wang J.,
Singh K.P.,
Zonin F.,
Vaisberg E.,
Churakova T.,
Liu M.-R.,
Gorman D.,
Wagner J.,
Zurawski S.,
Liu Y.-J.,
Abrams J.S., ![]()
Moore K.W.,
Rennick D.M.,
de Waal-Malefyt R.,
Hannum C.,
Bazan J.F.,
Kastelein R.A.;
"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.";
Immunity 13:715-725(2000).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Spleen;
Hirata Y.,
Kosuge Y.;
"SGRF; a novel member of the IL-6/G-CSF family.";
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F.,
Gurney A.L.,
Abaya E.,
Baker K.,
Baldwin D.T.,
Brush J.,
Chen J.,
Chow B.,
Chui C.,
Crowley C.,
Currell B.,
Deuel B.,
Dowd P.,
Eaton D.,
Foster J.S.,
Grimaldi C.,
Gu Q.,
Hass P.E.,
Heldens S., ![]()
Huang A.,
Kim H.S.,
Klimowski L.,
Jin Y.,
Johnson S.,
Lee J.,
Lewis L.,
Liao D.,
Mark M.R.,
Robbie E.,
Sanchez C.,
Schoenfeld J.,
Seshagiri S.,
Simmons L.,
Singh J.,
Smith V.,
Stinson J.,
Vagts A.,
Vandlen R.L.,
Watanabe C.,
Wieand D.,
Woods K.,
Xie M.-H.,
Yansura D.G.,
Yi S.,
Yu G.,
Yuan J.,
Zhang M.,
Zhang Z.,
Goddard A.D.,
Wood W.I.,
Godowski P.J.,
Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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FUNCTION, AND INTERACTION WITH IL12RB1 AND IL23R.
PubMed=12023369 [NCBI, ExPASy, EBI, Israel, Japan]
Parham C.,
Chirica M.,
Timans J.,
Vaisberg E.,
Travis M.,
Cheung J.,
Pflanz S.,
Zhang R.,
Singh K.P.,
Vega F.,
To W.,
Wagner J.,
O'Farrell A.-M.,
McClanahan T.K.,
Zurawski S.,
Hannum C.,
Gorman D.,
Rennick D.M.,
Kastelein R.A., ![]()
de Waal Malefyt R.,
Moore K.W.;
"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.";
J. Immunol. 168:5699-5708(2002).
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[6]
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INDUCTION.
PubMed=12421946 [NCBI, ExPASy, EBI, Israel, Japan]
Pirhonen J.,
Matikainen S.,
Julkunen I.;
"Regulation of virus-induced IL-12 and IL-23 expression in human macrophages.";
J. Immunol. 169:5673-5678(2002).
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[7]
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INDUCTION.
DOI=10.1002/eji.200324815; PubMed=15114670 [NCBI, ExPASy, EBI, Israel, Japan]
Smits H.H.,
van Beelen A.J.,
Hessle C.,
Westland R.,
de Jong E.,
Soeteman E.,
Wold A.,
Wierenga E.A.,
Kapsenberg M.L.;
"Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development.";
Eur. J. Immunol. 34:1371-1380(2004).
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[8]
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INDUCTION.
DOI=10.1182/blood-2004-05-1718; PubMed=15486065 [NCBI, ExPASy, EBI, Israel, Japan]
Schnurr M.,
Toy T.,
Shin A.,
Wagner M.,
Cebon J.,
Maraskovsky E.;
"Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway.";
Blood 105:1582-1589(2005).
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[9]
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INDUCTION.
DOI=10.1128/IAI.73.3.1590-1597.2005; PubMed=15731058 [NCBI, ExPASy, EBI, Israel, Japan]
Fedele G.,
Stefanelli P.,
Spensieri F.,
Fazio C.,
Mastrantonio P.,
Ausiello C.M.;
"Bordetella pertussis-infected human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization and interleukin-23 expression.";
Infect. Immun. 73:1590-1597(2005).
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[10]
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DEVELOPMENTAL STAGE.
DOI=10.1002/eji.200535467; PubMed=16342235 [NCBI, ExPASy, EBI, Israel, Japan]
Vanden Eijnden S.,
Goriely S.,
De Wit D.,
Goldman M.,
Willems F.;
"Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns.";
Eur. J. Immunol. 36:21-26(2006).
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[11]
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FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
PubMed=16424222 [NCBI, ExPASy, EBI, Israel, Japan]
Piskin G.,
Sylva-Steenland R.M.R.,
Bos J.D.,
Teunissen M.B.M.;
"In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin.";
J. Immunol. 176:1908-1915(2006).
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[12]
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INDUCTION.
PubMed=16751425 [NCBI, ExPASy, EBI, Israel, Japan]
Vaknin-Dembinsky A.,
Balashov K.,
Weiner H.L.;
"IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.";
J. Immunol. 176:7768-7774(2006).
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[13]
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INDUCTION.
DOI=10.1038/nature04808; PubMed=16688182 [NCBI, ExPASy, EBI, Israel, Japan]
Langowski J.L.,
Zhang X.,
Wu L.,
Mattson J.D.,
Chen T.,
Smith K.,
Basham B.,
McClanahan T.K.,
Kastelein R.A.,
Oft M.;
"IL-23 promotes tumour incidence and growth.";
Nature 442:461-465(2006).
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