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UniProtKB/Swiss-Prot entry Q9NPD7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NRN1_HUMAN
Primary accession number Q9NPD7
Secondary accession number Q7Z4Y1
Integrated into Swiss-Prot on November 28, 2006
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 49)
Name and origin of the protein
Protein name Neuritin [Precursor]
Synonyms None
Gene name
Name: NRN1
Synonyms: NRN
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Adrenal cortex;
DOI=10.1073/pnas.94.6.2648; PubMed=9122250 [NCBI, ExPASy, EBI, Israel, Japan]
Naeve G.S., Ramakrishnan M., Kramer R., Hevroni D., Citri Y., Theill L.E.;
"Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis.";
Proc. Natl. Acad. Sci. U.S.A. 94:2648-2653(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Zhou H., Huang X., Zhou Y., Hu S., Tang X., Yuan J., Qiang B.;
"Isolation and cloning of a novel human cDNA encoding rat neuritin homolog.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Fan Y.X., Yu L., Zhang X.N., Xin Y.R., Wang X.K., Zhao S.Y.;
"Cloning of a novel human cDNA homologous to Rattus norvegicus neuritin mRNA.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF136631; AAF62371.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF114833; AAP97232.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136307; CAC00777.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC002683; AAH02683.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC042019; AAH42019.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00470625; -.
RefSeq NP_057672.1; -.
UniGene Hs.103291
3D structure databases
ModBase Q9NPD7.
Organism-specific databases
GeneCards GC06M005943; -.
HGNC HGNC:17972; NRN1.
GenAtlas NRN1.
MIM 607409; gene. [NCBI / EBI]
PharmGKB PA38477; -.
Gene expression databases
ArrayExpress Q9NPD7; -.
Bgee Q9NPD7; -.
CleanEx HS_NRN1; -.
GermOnline ENSG00000124785; Homo sapiens.
Ontologies
GO
GO:0031225; Cellular component: anchored to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Proteomic databases
PeptideAtlas Q9NPD7; -.
PRIDE Q9NPD7; -.
Genome annotation databases
Ensembl ENSG00000124785; Homo sapiens. [Contig view]
GeneID 51299; -.
KEGG hsa:51299; -.
Phylogenomic databases
HOVERGEN Q9NPD7; -.
OMA Q9NPD7; LFELCGG.
Other
NextBio 54593; -.
SOURCE NRN1; Homo sapiens.
ProtoNet Q9NPD7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    27  27     Potential. 
CHAIN   28   116  89     Neuritin. PRO_0000262512
PROPEP   117   142  26     Removed in mature form (Potential). PRO_0000262513
LIPID   116   116        GPI-anchor amidated glycine (Potential). 
CONFLICT   48    49        SM -> TW (in Ref. 3; AAP97232). 
CONFLICT   55    56        GL -> AW (in Ref. 3; AAP97232). 
CONFLICT   113   115        SGN -> RAT (in Ref. 3; AAP97232). 
Sequence information
Length: 142 AA [This is the length of the unprocessed precursor] Molecular weight: 15333 Da [This is the MW of the unprocessed precursor] CRC64: 6C3C3DAC8D6392E6 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA NYPQGLDDKT 

        70         80         90        100        110        120 
NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN LNIQGSLFEL CGSGNGAAGS 

       130        140 
LLPAFPVLLV SLSAALATWL SF 

Q9NPD7 in FASTA format

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