[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
DOI=10.1074/jbc.M007603200; PubMed=11110791 [NCBI, ExPASy, EBI, Israel, Japan]
Brouwer R.,
Allmang C.,
Raijmakers R.,
van Aarssen Y.,
Egberts W.V.,
Petfalski E.,
van Venrooij W.J.,
Tollervey D.,
Pruijn G.J.M.;
"Three novel components of the human exosome.";
J. Biol. Chem. 276:6177-6184(2001).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T.,
Suzuki Y.,
Nishikawa T.,
Otsuki T.,
Sugiyama T.,
Irie R.,
Wakamatsu A.,
Hayashi K.,
Sato H.,
Nagai K.,
Kimura K.,
Makita H.,
Sekine M.,
Obayashi M.,
Nishi T.,
Shibahara T.,
Tanaka T.,
Ishii S.,
Yamamoto J., ![]()
Saito K.,
Kawai Y.,
Isono Y.,
Nakamura Y.,
Nagahari K.,
Murakami K.,
Yasuda T.,
Iwayanagi T.,
Wagatsuma M.,
Shiratori A.,
Sudo H.,
Hosoiri T.,
Kaku Y.,
Kodaira H.,
Kondo H.,
Sugawara M.,
Takahashi M.,
Kanda K.,
Yokoi T.,
Furuya T.,
Kikkawa E.,
Omura Y.,
Abe K.,
Kamihara K.,
Katsuta N.,
Sato K.,
Tanikawa M.,
Yamazaki M.,
Ninomiya K.,
Ishibashi T.,
Yamashita H.,
Murakawa K.,
Fujimori K.,
Tanai H.,
Kimata M.,
Watanabe M.,
Hiraoka S.,
Chiba Y.,
Ishida S.,
Ono Y.,
Takiguchi S.,
Watanabe S.,
Yosida M.,
Hotuta T.,
Kusano J.,
Kanehori K.,
Takahashi-Fujii A.,
Hara H.,
Tanase T.-O.,
Nomura Y.,
Togiya S.,
Komai F.,
Hara R.,
Takeuchi K.,
Arita M.,
Imose N.,
Musashino K.,
Yuuki H.,
Oshima A.,
Sasaki N.,
Aotsuka S.,
Yoshikawa Y.,
Matsunawa H.,
Ichihara T.,
Shiohata N.,
Sano S.,
Moriya S.,
Momiyama H.,
Satoh N.,
Takami S.,
Terashima Y.,
Suzuki O.,
Nakagawa S.,
Senoh A.,
Mizoguchi H.,
Goto Y.,
Shimizu F.,
Wakebe H.,
Hishigaki H.,
Watanabe T.,
Sugiyama A.,
Takemoto M.,
Kawakami B.,
Yamazaki M.,
Watanabe K.,
Kumagai A.,
Itakura S.,
Fukuzumi Y.,
Fujimori Y.,
Komiyama M.,
Tashiro H.,
Tanigami A.,
Fujiwara T.,
Ono T.,
Yamada K.,
Fujii Y.,
Ozaki K.,
Hirao M.,
Ohmori Y.,
Kawabata A.,
Hikiji T.,
Kobatake N.,
Inagaki H.,
Ikema Y.,
Okamoto S.,
Okitani R.,
Kawakami T.,
Noguchi S.,
Itoh T.,
Shigeta K.,
Senba T.,
Matsumura K.,
Nakajima Y.,
Mizuno T.,
Morinaga M.,
Sasaki M.,
Togashi T.,
Oyama M.,
Hata H.,
Watanabe M.,
Komatsu T.,
Mizushima-Sugano J.,
Satoh T.,
Shirai Y.,
Takahashi Y.,
Nakagawa K.,
Okumura K.,
Nagase T.,
Nomura N.,
Kikuchi H.,
Masuho Y.,
Yamashita R.,
Nakai K.,
Yada T.,
Nakamura Y.,
Ohara O.,
Isogai T.,
Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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PROTEIN SEQUENCE OF 2-13, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, AND MASS SPECTROMETRY.
TISSUE=Cervix carcinoma;
Bienvenut W.V.;
Submitted (OCT-2004) to UniProtKB.
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[5]
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CHARACTERIZATION.
PubMed=10465791 [NCBI, ExPASy, EBI, Israel, Japan]
Allmang C.,
Petfalski E.,
Podtelejnikov A.,
Mann M.,
Tollervey D.,
Mitchell P.;
"The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases.";
Genes Dev. 13:2148-2158(1999).
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[6]
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IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX.
DOI=10.1016/S0092-8674(01)00578-5; PubMed=11719186 [NCBI, ExPASy, EBI, Israel, Japan]
Chen C.-Y.,
Gherzi R.,
Ong S.-E.,
Chan E.L.,
Raijmakers R.,
Pruijn G.J.M.,
Stoecklin G.,
Moroni C.,
Mann M.,
Karin M.;
"AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.";
Cell 107:451-464(2001).
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[7]
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IDENTIFICATION IN A MRNA DECAY COMPLEX WITH RENT1; RENT2 AND RENT3B.
DOI=10.1016/S1097-2765(03)00349-6; PubMed=14527413 [NCBI, ExPASy, EBI, Israel, Japan]
Lejeune F.,
Li X.,
Maquat L.E.;
"Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.";
Mol. Cell 12:675-687(2003).
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- FUNCTION: Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. Required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3'-5' exonuclease activity.
- SUBUNIT: Component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: EXOSC1/CSL4, EXOSC2/RRP4, EXOSC3/RRP40, EXOSC4/RRP41, EXOSC5/RRP46, EXOSC6/MTR3, EXOSC7/RRP42, EXOSC8/RRP43, EXOSC9/Scl-75, DIS3/RRP44, and EXOSC10/Scl-100 (only in the nuclear complex). Found in a mRNA decay complex with RENT1, RENT2 and RENT3B. Also associated with the GTPase Ran.
- INTERACTION:
P14550:AKR1A1; NbExp=1; IntAct=EBI-371823, EBI-372388;
O77932:DOM3Z; NbExp=1; IntAct=EBI-371823, EBI-372173;
P68104:EEF1A1; NbExp=1; IntAct=EBI-371823, EBI-352162;
Q9Y3B2:EXOSC1; NbExp=2; IntAct=EBI-371823, EBI-371892;
Q01780:EXOSC10; NbExp=1; IntAct=EBI-371823, EBI-358236;
Q9NQT5:EXOSC3; NbExp=1; IntAct=EBI-371823, EBI-371866;
Q06265:EXOSC9; NbExp=1; IntAct=EBI-371823, EBI-347966;
Q6P587:FAHD1; NbExp=1; IntAct=EBI-371823, EBI-597013;
Q8TAE8:GADD45GIP1; NbExp=1; IntAct=EBI-371823, EBI-372506;
Q9UHL9:GTF2IRD1; NbExp=1; IntAct=EBI-371823, EBI-372530;
Q14103-3:HNRNPD; NbExp=1; IntAct=EBI-371823, EBI-432539;
Q7L1W4:LRRC8D; NbExp=1; IntAct=EBI-371823, EBI-861997;
Q8WUP4:MPZL1; NbExp=1; IntAct=EBI-371823, EBI-372210;
Q96PY6:NEK1; NbExp=1; IntAct=EBI-371823, EBI-373615;
Q15477:SKIV2L; NbExp=1; IntAct=EBI-371823, EBI-373226;
Q9NXE4:SMPD4; NbExp=1; IntAct=EBI-371823, EBI-372102;
Q8WW01:TSEN15; NbExp=1; IntAct=EBI-371823, EBI-372432;
- SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus.
- SIMILARITY: Belongs to the RNase PH family.
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