ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q9NP97


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name DLRB1_HUMAN
Primary accession number Q9NP97
Secondary accession numbers Q5TC72 Q96IV3 Q9NQM2
Integrated into Swiss-Prot on April 23, 2003
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 69)
Name and origin of the protein
Protein name Dynein light chain roadblock-type 1
Synonyms Dynein light chain 2A, cytoplasmic
Dynein-associated protein Km23
Bithoraxoid-like protein
BLP
Gene name
Name: DYNLRB1
Synonyms: BITH, DNCL2A, DNLC2A
ORFNames: HSPC162
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Liver, and Testis;
DOI=10.1016/S0378-1119(01)00787-9; PubMed=11750132 [NCBI, ExPASy, EBI, Israel, Japan]
Jiang J., Yu L., Huang X., Chen X., Li D., Zhang Y., Tang L., Zhao S.;
"Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients.";
Gene 281:103-113(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Hematopoietic stem cell;
Gu J., Huang Q., Yu Y., Xu S., Han Z., Fu G., Zhou J., Wang Y., Huang C., Ren S., Tu Y., Chen Z.;
"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients.";
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Fracchiolla N.S., Cortelezzi A., Lambertenghi-Deliliers G.;
"BitH, a human homolog of bithorax Drosophila melanogaster gene, on chromosome 20q.";
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Placenta;
Tang Q., Staub C.M., Mulder K.M.;
"Km23: role in growth factor signaling.";
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Umbilical cord blood;
DOI=10.1101/gr.140200; PubMed=11042152 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.";
Genome Res. 10:1546-1560(2000).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Kidney, and Lymph;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
PROTEIN SEQUENCE OF 2-10.
TISSUE=Platelet;
DOI=10.1038/nbt810; PubMed=12665801 [NCBI, ExPASy, EBI, Israel, Japan]
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.;
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.";
Nat. Biotechnol. 21:566-569(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF132750; AAL75951.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF165516; AAF86646.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF178431; AAK95342.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY026513; AAK18712.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF161511; AAF29126.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL109923; CAI21456.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136173; CAI21456.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136173; CAI23308.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL109923; CAI23308.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC002481; AAH02481.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007223; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
RefSeq NP_054902.1; -.
UniGene Hs.593920
3D structure databases
PDB
1Z09; NMR; -; A/B=1-96.[ExPASy / RCSB / EBI]
2B95; NMR; -; A/B=1-96.[ExPASy / RCSB / EBI]
2E8J; NMR; -; A/B=1-96.[ExPASy / RCSB / EBI]
2HZ5; X-ray; 2.10 A; A/B=1-96.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1Z09; -.
2B95; -.
2E8J; -.
2HZ5; -.
ModBase Q9NP97.
Protein-protein interaction databases
IntAct Q9NP97; -.
Organism-specific databases
HGNC HGNC:15468; DYNLRB1.
GenAtlas DYNLRB1.
HPA CAB009845; -.
MIM 607167; gene. [NCBI / EBI]
PharmGKB PA27436; -.
GeneCards Q9NP97.
Gene expression databases
ArrayExpress Q9NP97; -.
CleanEx HS_DYNLRB1; -.
GermOnline ENSG00000125971; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0005868; Cellular component: cytoplasmic dynein complex (non-traceable author statement from UniProtKB).
GO:0003777; Molecular function: microtubule motor activity (non-traceable author statement from UniProtKB).
GO:0005515; Molecular function: protein binding (non-traceable author statement from UniProtKB).
GO:0007018; Biological process: microtubule-based movement (non-traceable author statement from UniProtKB).
GO:0007632; Biological process: visual behavior (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR004942; Dynein_light-rel.
IPR016561; Dynein_light_roadblock-type.
Graphical view of domain structure.
Pfam PF03259; Robl_LC7; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF009998; DLC7; 1.
BLOCKS Q9NP97.
Genome annotation databases
Ensembl ENSG00000125971; Homo sapiens. [Contig view]
GeneID 83658; -.
KEGG hsa:83658; -.
Phylogenomic databases
HOVERGEN Q9NP97; -.
Other
LinkHub Q9NP97; -.
SOURCE DYNLRB1; Homo sapiens.
ProtoNet Q9NP97.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Acetylation; Alternative splicing; Cytoplasm; Direct protein sequencing; Dynein; Microtubule; Motor protein.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
INIT_MET   1    1        Removed. 
CHAIN   2   96  95     Dynein light chain roadblock-type 1. PRO_0000220955
MOD_RES   2    2        N-acetylalanine (By similarity). 
VAR_SEQ   28   47        IPIKSTMDNPTTTQYASLMH -> GWEPLGHCGDRSRPPAQGCP (in isoform 2). VSP_007236
VAR_SEQ   48   96        Missing (in isoform 2). VSP_007237
HELIX   6   12  7      
STRAND   17   23  7      
STRAND   29   34  6      
HELIX   36   60  25      
STRAND   66   75  10      
STRAND   77   81  5      
STRAND   87   92  6      
Sequence information
Length: 96 AA [This is the length of the unprocessed precursor] Molecular weight: 10922 Da [This is the MW of the unprocessed precursor] CRC64: AAE1EFCD372897B3 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAEVEETLKR LQSQKGVQGI IVVNTEGIPI KSTMDNPTTT QYASLMHSFI LKARSTVRDI 

        70         80         90 
DPQNDLTFLR IRSKKNEIMV APDKDYFLIV IQNPTE 

Q9NP97 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!