ID AFB3_ARATH Reviewed; 577 AA. AC Q9LPW7; DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 25-NOV-2008, entry version 51. DE RecName: Full=Protein AUXIN SIGNALING F-BOX 3; GN Name=AFB3; OrderedLocusNames=At1g12820; ORFNames=F13K23.7; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; OC rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX MEDLINE=21016719; PubMed=11130712; DOI=10.1038/35048500; RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., RA White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., RA Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., RA Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., RA Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., RA Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., RA Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., RA Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., RA Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., RA Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., RA Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., RA Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., RA Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., RA Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., RA Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.; RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis RT thaliana."; RL Nature 408:816-820(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K., RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., RA Hayashizaki Y., Shinozaki K.; RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. RN [4] RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INTERACTION RP WITH CUL1; IAA7; IAA12 AND SKP1A/ASK1. RX PubMed=15992545; DOI=10.1016/j.devcel.2005.05.014; RA Dharmasiri N., Dharmasiri S., Weijers D., Lechner E., Yamada M., RA Hobbie L., Ehrismann J.S., Juergens G., Estelle M.; RT "Plant development is regulated by a family of auxin receptor F box RT proteins."; RL Dev. Cell 9:109-119(2005). RN [5] RP FUNCTION. RX PubMed=15917797; DOI=10.1038/nature03543; RA Dharmasiri N., Dharmasiri S., Estelle M.; RT "The F-box protein TIR1 is an auxin receptor."; RL Nature 435:441-445(2005). RN [6] RP INDUCTION. RX PubMed=16627744; DOI=10.1126/science.1126088; RA Navarro L., Dunoyer P., Jay F., Arnold B., Dharmasiri N., Estelle M., RA Voinnet O., Jones J.D.G.; RT "A plant miRNA contributes to antibacterial resistance by repressing RT auxin signaling."; RL Science 312:436-439(2006). CC -!- FUNCTION: Confers sensitivity to the virulent bacterial pathogen CC P.syringae (By similarity). Auxin receptor that mediates Aux/IAA CC proteins proteasomal degradation and auxin-regulated CC transcription. Involved in embryogenesis regulation by auxin. CC -!- PATHWAY: Protein modification; protein ubiquitination. CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. CC Interacts with CUL1 and SKP1A/ASK1. Interacts with Aux/IAA CC proteins (IAA7 and IAA12) in an auxin-dependent manner. CC -!- INTERACTION: CC Q38830:IAA12; NbExp=1; IntAct=EBI-617501, EBI-617608; CC Q38825:IAA7; NbExp=1; IntAct=EBI-617501, EBI-602959; CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- TISSUE SPECIFICITY: Ubiquitous, with higher levels in flowers. CC -!- INDUCTION: Repressed by miR393a (microRNA) in response to flg-22 CC (flagellin-derived peptide 22). CC -!- SIMILARITY: Contains 1 F-box domain. CC -!- SIMILARITY: Contains 16 LRR (leucine-rich) repeats. CC -!- WEB RESOURCE: Name=PlantsUBQ; Note=A functional genomics database CC for the ubiquitin/26S proteasome proteolytic pathway in plants; CC URL="http://plantsubq.genomics.purdue.edu/"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AE005172; AAF78487.1; -; Genomic_DNA. DR EMBL; AY099541; AAM20393.1; -; mRNA. DR EMBL; BT002118; AAN72129.1; -; mRNA. DR EMBL; AK227280; BAE99304.1; -; mRNA. DR PIR; F86261; F86261. DR RefSeq; NP_563915.1; -. DR UniGene; At.71229; -. DR IntAct; Q9LPW7; -. DR GeneID; 837838; -. DR GenomeReviews; CT485782_GR; AT1G12820. DR KEGG; ath:AT1G12820; -. DR NMPDR; fig|3702.1.peg.1550; -. DR TAIR; At1g12820; -. DR ArrayExpress; Q9LPW7; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0009734; P:auxin mediated signaling pathway; IEA:UniProtKB-KW. DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW. DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:UniProtKB-KW. DR InterPro; IPR001810; F-box. DR SMART; SM00256; FBOX; 1. DR PROSITE; PS50181; FBOX; FALSE_NEG. PE 1: Evidence at protein level; KW Auxin signaling pathway; Complete proteome; Developmental protein; KW Leucine-rich repeat; Nucleus; Plant defense; Repeat; KW Ubl conjugation pathway. FT CHAIN 1 577 Protein AUXIN SIGNALING F-BOX 3. FT /FTId=PRO_0000272244. FT DOMAIN 1 45 F-box. FT REPEAT 91 108 LRR 1. FT REPEAT 109 141 LRR 2. FT REPEAT 142 169 LRR 3. FT REPEAT 170 196 LRR 4. FT REPEAT 197 223 LRR 5. FT REPEAT 224 250 LRR 6. FT REPEAT 251 274 LRR 7. FT REPEAT 275 300 LRR 8. FT REPEAT 301 324 LRR 9. FT REPEAT 325 359 LRR 10. FT REPEAT 360 384 LRR 11. FT REPEAT 385 419 LRR 12. FT REPEAT 420 446 LRR 13. FT REPEAT 447 468 LRR 14. FT REPEAT 469 490 LRR 15. FT REPEAT 491 514 LRR 16. SQ SEQUENCE 577 AA; 64906 MW; 8E419B4D83068661 CRC64; MNYFPDEVIE HVFDFVASHK DRNSISLVCK SWHKIERFSR KEVFIGNCYA INPERLIRRF PCLKSLTLKG KPHFADFNLV PHEWGGFVHP WIEALARSRV GLEELRLKRM VVTDESLDLL SRSFANFKSL VLVSCEGFTT DGLASIAANC RHLRELDLQE NEIDDHRGQW LNCFPDSCTT LMSLNFACLK GETNVAALER LVARSPNLKS LKLNRAVPLD ALARLMSCAP QLVDLGVGSY ENEPDPESFA KLMTAIKKYT SLRSLSGFLE VAPLCLPAFY PICQNLISLN LSYAAEIQGN HLIKLIQLCK RLQRLWILDS IGDKGLAVVA ATCKELQELR VFPSDVHGEE DNNASVTEVG LVAISAGCPK LHSILYFCKQ MTNAALIAVA KNCPNFIRFR LCILEPHKPD HITFQSLDEG FGAIVQACKG LRRLSVSGLL TDQVFLYIGM YAEQLEMLSI AFAGDTDKGM LYVLNGCKKM RKLEIRDSPF GNAALLADVG RYETMRSLWM SSCEVTLGGC KRLAQNSPRL NVEIINENEN NGMEQNEEDE REKVDKLYLY RTVVGTRKDA PPYVRIL //