ID   APRR1_ARATH             Reviewed;         618 AA.
AC   Q9LKL2; Q9M4B7;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   22-JUL-2008, entry version 58.
DE   RecName: Full=Two-component response regulator-like APRR1;
DE   AltName: Full=Pseudo-response regulator 1;
DE   AltName: Full=Timing of CAB expression 1;
DE   AltName: Full=ABI3-interacting protein 1;
GN   Name=APRR1; Synonyms=AIP1, TOC1; OrderedLocusNames=At5g61380;
GN   ORFNames=MFB13.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, CHARACTERIZATION, AND GENE FAMILY.
RC   STRAIN=cv. Columbia;
RX   MEDLINE=20399447; PubMed=10945350;
RA   Makino S., Kiba T., Imamura A., Hanaki N., Nakamura A., Suzuki T.,
RA   Taniguchi M., Ueguchi C., Sugiyama T., Mizuno T.;
RT   "Genes encoding pseudo-response regulators: insight into His-to-Asp
RT   phosphorelay and circadian rhythm in Arabidopsis thaliana.";
RL   Plant Cell Physiol. 41:791-803(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND MUTAGENESIS OF ALA-562.
RC   STRAIN=cv. Columbia;
RX   MEDLINE=20385063; PubMed=10926537; DOI=10.1126/science.289.5480.768;
RA   Strayer C., Oyama T., Schultz T.F., Raman R., Somers D.E., Mas P.,
RA   Panda S., Kreps J.A., Kay S.A.;
RT   "Cloning of the Arabidopsis clock gene TOC1, an autoregulatory
RT   response regulator homolog.";
RL   Science 289:768-771(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INTERACTION WITH
RP   ABI3.
RC   STRAIN=cv. Landsberg erecta;
RX   MEDLINE=20208058; PubMed=10743655;
RA   Kurup S., Jones H.D., Holdsworth M.J.;
RT   "Interactions of the developmental regulator ABI3 with proteins
RT   identified from developing Arabidopsis seeds.";
RL   Plant J. 21:143-155(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=98290546; PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA   Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IV.
RT   Sequence features of the regions of 1,456,315 bp covered by nineteen
RT   physically assigned P1 and TAC clones.";
RL   DNA Res. 5:41-54(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [6]
RP   FUNCTION.
RX   PubMed=11100772; DOI=10.1093/pcp/pcd043;
RA   Matsushika A., Makino S., Kojima M., Mizuno T.;
RT   "Circadian waves of expression of the APRR1/TOC1 family of pseudo-
RT   response regulators in Arabidopsis thaliana: insight into the plant
RT   circadian clock.";
RL   Plant Cell Physiol. 41:1002-1012(2000).
RN   [7]
RP   INDUCTION.
RX   PubMed=11486091; DOI=10.1126/science.1061320;
RA   Alabadi D., Oyama T., Yanovsky M.J., Harmon F.G., Mas P., Kay S.A.;
RT   "Reciprocal regulation between TOC1 and LHY/CCA1 within the
RT   Arabidopsis circadian clock.";
RL   Science 293:880-883(2001).
RN   [8]
RP   INTERACTION WITH ADO1 AND ADO2.
RX   PubMed=15310821; DOI=10.1093/jxb/erh226;
RA   Yasuhara M., Mitsui S., Hirano H., Takanabe R., Tokioka Y., Ihara N.,
RA   Komatsu A., Seki M., Shinozaki K., Kiyosue T.;
RT   "Identification of ASK and clock-associated proteins as molecular
RT   partners of LKP2 (LOV kelch protein 2) in Arabidopsis.";
RL   J. Exp. Bot. 55:2015-2027(2004).
CC   -!- FUNCTION: Controls photoperiodic flowering response. Seems to be
CC       one of the component of the circadian clock. Expression of several
CC       members of the ARR-like family is controlled by circadian rhythm.
CC       The particular coordinated sequential expression of APRR9, APRR7,
CC       APRR5, APRR3 and APPR1 result to circadian waves that may be at
CC       the basis of the endogenous circadian clock.
CC   -!- SUBUNIT: Interacts with ABI3. Also interacts with ADO1 and ADO2.
CC   -!- INTERACTION:
CC       Q94BT6:ADO1; NbExp=4; IntAct=EBI-618423, EBI-300691;
CC       Q8W420:ADO2; NbExp=2; IntAct=EBI-618423, EBI-1015688;
CC       Q9LVG4:APRR3; NbExp=1; IntAct=EBI-618423, EBI-1606968;
CC       O80727:At2g46970; NbExp=3; IntAct=EBI-618423, EBI-630752;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in leaves, flowers and siliques.
CC   -!- INDUCTION: Expressed with a circadian rhythm showing a broad peak
CC       in the late day. Negatively regulated by LHY and CCA1.
CC   -!- SIMILARITY: Belongs to the ARR-like family.
CC   -!- SIMILARITY: Contains 1 CCT domain.
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
CC   -!- CAUTION: Lacks the phospho-accepting Asp (here Glu-71), present in
CC       the receiver domain, which is one of the conserved features of the
CC       two-component response regulators (ARRs) family.
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DR   EMBL; AB041530; BAA94547.1; -; mRNA.
DR   EMBL; AF272039; AAF86252.1; -; mRNA.
DR   EMBL; AJ251086; CAB75508.1; -; mRNA.
DR   EMBL; AB010073; BAB08493.1; -; Genomic_DNA.
DR   EMBL; AY094393; AAM19772.1; -; mRNA.
DR   EMBL; BT005816; AAO64751.1; -; mRNA.
DR   PIR; T52075; T52075.
DR   PIR; T52076; T52076.
DR   RefSeq; NP_200946.1; -.
DR   UniGene; At.21919; -.
DR   IntAct; Q9LKL2; -.
DR   GeneID; 836259; -.
DR   GenomeReviews; BA000015_GR; AT5G61380.
DR   KEGG; ath:AT5G61380; -.
DR   NMPDR; fig|3702.1.peg.28159; -.
DR   GeneFarm; 4313; 437.
DR   TAIR; At5g61380; -.
DR   ArrayExpress; Q9LKL2; -.
DR   GermOnline; AT5G61380; Arabidopsis thaliana.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0030528; F:transcription regulator activity; TAS:TAIR.
DR   InterPro; IPR010402; CCT.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF06203; CCT; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   ProDom; PD000039; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   PROSITE; PS51017; CCT; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Complete proteome; Nucleus; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN         1    618       Two-component response regulator-like
FT                                APRR1.
FT                                /FTId=PRO_0000081435.
FT   DOMAIN       20    138       Response regulatory.
FT   DOMAIN      533    575       CCT.
FT   COILED      588    610       Potential.
FT   COMPBIAS    595    605       Poly-Glu.
FT   MUTAGEN     562    562       A->V: In toc1-1; causes shortened
FT                                circadian rhythms in light-grown plants.
FT   CONFLICT    126    126       R -> L (in Ref. 2; CAB75508).
SQ   SEQUENCE   618 AA;  69195 MW;  EDBE0AA0B7FAB61E CRC64;
     MDLNGECKGG DGFIDRSRVR ILLCDNDSTS LGEVFTLLSE CSYQVTAVKS ARQVIDALNA
     EGPDIDIILA EIDLPMAKGM KMLRYITRDK DLRRIPVIMM SRQDEVPVVV KCLKLGAADY
     LVKPLRTNEL LNLWTHMWRR RRMLGLAEKN MLSYDFDLVG SDQSDPNTNS TNLFSDDTDD
     RSLRSTNPQR GNLSHQENEW SVATAPVHAR DGGLGADGTA TSSLAVTAIE PPLDHLAGSH
     HEPMKRNSNP AQFSSAPKKS RLKIGESSAF FTYVKSTVLR TNGQDPPLVD GNGSLHLHRG
     LAEKFQVVAS EGINNTKQAR RATPKSTVLR TNGQDPPLVN GNGSHHLHRG AAEKFQVVAS
     EGINNTKQAH RSRGTEQYHS QGETLQNGAS YPHSLERSRT LPTSMESHGR NYQEGNMNIP
     QVAMNRSKDS SQVDGSGFSA PNAYPYYMHG VMNQVMMQSA AMMPQYGHQI PHCQPNHPNG
     MTGYPYYHHP MNTSLQHSQM SLQNGQMSMV HHSWSPAGNP PSNEVRVNKL DRREEALLKF
     RRKRNQRCFD KKIRYVNRKR LAERRPRVKG QFVRKMNGVN VDLNGQPDSA DYDDEEEEEE
     EEEEENRDSS PQDDALGT
//