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UniProtKB/Swiss-Prot entry Q9KPZ7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COPA_VIBCH
Primary accession number Q9KPZ7
Secondary accession numbers None
Integrated into Swiss-Prot on April 3, 2002
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    September 23, 2008 (Entry version 56)
Name and origin of the protein
Protein name Copper-exporting P-type ATPase A
Synonym EC 3.6.3.n1
Gene name
Name: copA
OrderedLocusNames: VC_2215
From
Vibrio cholerae [TaxID: 666] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 39315 / El Tor Inaba N16961 / Serotype O1;
DOI=10.1038/35020000; PubMed=10952301 [NCBI, ExPASy, EBI, Israel, Japan]
Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.";
Nature 406:477-483(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE003852; AAF95359.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H82104; H82104.
RefSeq NP_231846.1; -.
3D structure databases
HSSP Q47840; 1CPZ. [HSSP ENTRY / PDB]
ModBase Q9KPZ7.
Family and domain databases
InterPro IPR006416; ATPase-IB_hvy.
IPR001757; ATPase_P.
IPR000579; ATPase_P_cat.
IPR006403; ATPase_P_cat/Cu.
IPR008250; E1-E2_ATPase_reg.
IPR006121; HeavyMe_transpt.
IPR001802; HG_scavenger.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00122; E1-E2_ATPase; 1.
PF00403; HMA; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00940; CATPATPASEA.
PR00946; HGSCAVENGER.
TIGRFAMs TIGR01511; ATPase-IB1_Cu; 1.
TIGR01525; ATPase-IB_hvy; 1.
TIGR01494; ATPase_P-type; 1.
PROSITE PS00154; ATPASE_E1_E2; 1.
PS01047; HMA_1; 1.
PS50846; HMA_2; 3.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9KPZ7.
Genome annotation databases
GeneID 2613254; -.
GenomeReviews AE003852_GR; VC_2215.
KEGG vch:VC2215; -.
TIGR VC_2215; -.
Phylogenomic databases
HOGENOM Q9KPZ7; -.
Other
ProtoNet Q9KPZ7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell membrane; Complete proteome; Copper; Copper transport; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Repeat; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   915  915     Copper-exporting P-type ATPase A. PRO_0000046324
TRANSMEM   265   285  21     Potential. 
TRANSMEM   293   313  21     Potential. 
TRANSMEM   329   349  21     Potential. 
TRANSMEM   359   379  21     Potential. 
TRANSMEM   474   494  21     Potential. 
TRANSMEM   514   534  21     Potential. 
TRANSMEM   541   561  21     Potential. 
TRANSMEM   801   821  21     Potential. 
TRANSMEM   865   885  21     Potential. 
DOMAIN   12    73  62     HMA 1. 
DOMAIN   74   135  62     HMA 2. 
DOMAIN   173   237  65     HMA 3. 
ACT_SITE   598   598        4-aspartylphosphate intermediate (Probable). 
METAL   22    22        Copper (Potential). 
METAL   25    25        Copper (Potential). 
METAL   84    84        Copper (Potential). 
METAL   87    87        Copper (Potential). 
METAL   183   183        Copper (Potential). 
METAL   186   186        Copper (Potential). 
METAL   796   796        Magnesium (By similarity). 
METAL   800   800        Magnesium (By similarity). 
Sequence information
Length: 915 AA [This is the length of the unprocessed precursor] Molecular weight: 97312 Da [This is the MW of the unprocessed precursor] CRC64: 2F31EE2640AD0D20 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDIPQGGVIM NHFALALRGL NCMGCARKLE RQLNQDLTVE IETLTPTSIE LHTHATLNEV 

        70         80         90        100        110        120 
LTSIESLGYQ GGTEQTYQLQ GLNCGRCVNK LTTHLSAQAE IAKLHVSKER LSLVTTLTAE 

       130        140        150        160        170        180 
QVKALVAEVG YQAIEAEQES TFAPAASIDE KETDTPDAEN SSNTEATEAS SQTLSLLIKG 

       190        200        210        220        230        240 
MTCASCVASV EKALLSVEGV QSAQVNLTEQ SALVRGIFAN PQPLLNAIQS SGYQAEILDD 

       250        260        270        280        290        300 
PAQQQAKQQA QLEALQKEHK QSALLGIALG TPLMLWGVFG GNMMIRNSSD QMVWGGIGTI 

       310        320        330        340        350        360 
CFALLLTAGR HFFMNAWQAL THGRATMDTL VALGTGAAWF YSMLVVAWPQ TFPDAARHVY 

       370        380        390        400        410        420 
FEATAMIIGL ISLGHYIETK AKSNTNRSLQ ALLNLQPQQA TLVTEQGDQS IAVADIQLGM 

       430        440        450        460        470        480 
SLRIKPGEQV PVDGVVSTGH SYLDESMLTG EPIPVLKEAG AKVAAGTLNQ DGSLVITATG 

       490        500        510        520        530        540 
IGAQTMLARI IQMVRQAQSS KPAMARLADQ ISSVFVPVVV VIAILSAALW YLYGPDPKAS 

       550        560        570        580        590        600 
YMLVVATTVL IIACPCALGL ATPLSITVGI GKAAEMGILI RDANVLQTAS QVDTVVFDKT 

       610        620        630        640        650        660 
GTLTLGKPSI QSLHVLQGDE NQLLALAYAL EQQSEHPLAK AICDYAKQRN ISPVEISQFT 

       670        680        690        700        710        720 
NQRGRGLLAD YQNQTVLVGS LAFMQEQGID LSMAESTLEK FAAQAWTPVA VAYRGMLQGV 

       730        740        750        760        770        780 
LAIADPIKPT SAQAVRKLNE LGIHTVMLTG DHTSVANAIA KELGISQVIA QVLPDQKAQH 

       790        800        810        820        830        840 
IQALQQQGRK VAMIGDGIND APALALADIG IAMGSGSDVA IESAQMTLLN SSPTSVVSAI 

       850        860        870        880        890        900 
ELSKATLRNM KQNLFGAFIY NTLGIPIAAG VLYPAFGFLL SPVVAGAAMA LSSITVVSNA 

       910 
NRLRWSKISF DQHSQ
Q9KPZ7 in FASTA format

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