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UniProtKB/Swiss-Prot entry Q9JLF6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TGM1_MOUSE
Primary accession number Q9JLF6
Secondary accession number Q8R0T9
Integrated into Swiss-Prot on January 4, 2005
Sequence was last modified on January 4, 2005 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 53)
Name and origin of the protein
Protein name Protein-glutamine gamma-glutamyltransferase K
Synonyms EC 2.3.2.13
Transglutaminase K
TGase K
TGK
TG(K)
Transglutaminase-1
Epidermal TGase
Gene name
Name: Tgm1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION, AND TISSUE SPECIFICITY.
DOI=10.1074/jbc.274.48.34148; PubMed=10567386 [NCBI, ExPASy, EBI, Israel, Japan]
Hiiragi T., Sasaki H., Nagafuchi A., Sabe H., Shen S.C., Matsuki M., Yamanishi K., Tsukita S.;
"Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells.";
J. Biol. Chem. 274:34148-34154(1999).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
 PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-91 AND SER-94, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan]
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF186373; AAF35986.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC026422; AAH26422.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_064368.2; -.
UniGene Mm.41964
3D structure databases
HSSP P00488; 1EX0. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase Q9JLF6.
PTM databases
PhosphoSite Q9JLF6; -.
Organism-specific databases
MGI MGI:98730; Tgm1.
Gene expression databases
ArrayExpress Q9JLF6; -.
CleanEx MM_TGM1; -.
GermOnline ENSMUSG00000022218; Mus musculus.
Ontologies
GO
GO:0005913; Cellular component: cell-cell adherens junction (inferred from direct assay from MGI).
GO:0009887; Biological process: organ morphogenesis (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR008957; Fibronectin_typ-III-like_fold.
IPR013783; Ig-like_fold.
IPR008958; Transglutaminase_C.
IPR013808; Transglutaminase_CS.
IPR001102; Transglutaminase_N.
IPR002931; Trnsglumase_like.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.30; FN_III-like; 1.
G3DSA:2.60.40.10; Ig-like_fold; 1.
Pfam PF00927; Transglut_C; 2.
PF01841; Transglut_core; 1.
PF00868; Transglut_N; 1.
Pfam graphical view of domain structure.
SMART SM00460; TGc; 1.
SMART graphical view of domain structure.
PROSITE PS00547; TRANSGLUTAMINASES; 1.
BLOCKS Q9JLF6.
Genome annotation databases
Ensembl ENSMUSG00000022218; Mus musculus. [Contig view]
GeneID 21816; -.
KEGG mmu:21816; -.
Phylogenomic databases
HOGENOM Q9JLF6; -.
HOVERGEN Q9JLF6; -.
Other
SOURCE Tgm1; Mus musculus.
ProtoNet Q9JLF6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Calcium; Keratinization; Membrane; Metal-binding; Phosphoprotein; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   815  815     Protein-glutamine gamma-glutamyltransferase K. PRO_0000213702
ACT_SITE   376   376        By similarity. 
ACT_SITE   435   435        By similarity. 
ACT_SITE   458   458        By similarity. 
METAL   498   498        Calcium (By similarity). 
METAL   500   500        Calcium (By similarity). 
METAL   547   547        Calcium (By similarity). 
METAL   552   552        Calcium (By similarity). 
MOD_RES   71    71        Phosphoserine. 
MOD_RES   91    91        Phosphoserine. 
MOD_RES   94    94        Phosphoserine. 
CONFLICT   29    29        E -> V (in Ref. 1; AAF35986). 
Sequence information
Length: 815 AA [This is the length of the unprocessed precursor] Molecular weight: 89826 Da [This is the MW of the unprocessed precursor] CRC64: 326DD4E512AEA23E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEGPRSDVGR WGRSPWQPPT TPSPEPEPEP EPDRRSRSRR GGGRSFWARC CGCCSCGNRG 

        70         80         90        100        110        120 
DDDWGPEPSG SRSRGTSSRG RDSRGGRRPE SRGSGVNAAG DGTIREGMLV VTGVDLLCSR 

       130        140        150        160        170        180 
SDQNRREHHT DEFEYDELIV RRGQPFHMIL FLNREYESSD RIALELLIGS NPEVGKGTHV 

       190        200        210        220        230        240 
IIPVGKGGSG GWKAQVTKNN GHNLNLRVHT SPNAIIGKFQ FTVRTRSEAG EFQLPFDPRN 

       250        260        270        280        290        300 
EIYILFNPWC PEDIVYVDHE DWRQEYVLNE SGRIYYGTEA QIGERTWNYG QFDHGVLDAC 

       310        320        330        340        350        360 
LYILDRRGMP YGGRGDPVSV SRVVSAMVNS LDDNGVLIGN WTGDYSRGTN PSAWVGSVEI 

       370        380        390        400        410        420 
LLSYLRTGYS VPYGQCWVFA GVTTTVLRCL GFATRTVTNF NSAHDTDTSL TMDIYFDENM 

       430        440        450        460        470        480 
KPLEHLNHDS VWNFHVWNDC WMKRPDLPSG FDGWQVVDAT PQETSSGIFC CGPCSVESVK 

       490        500        510        520        530        540 
NGLVYMKYDT PFIFAEVNSD KVYWQRQDDG SFKIVYVEEK AIGTLIVTKA IHSNNREDIT 

       550        560        570        580        590        600 
HIYKHPEGSE AERRAVEKAA AHGSKPNVYA TRDSAEDVAM QVEAQDAVMG QDLAVSVVLT 

       610        620        630        640        650        660 
NRGSSRRTVK LHLYLCVTYY TGVSGPTFKE AKKEVTLAPG ASDSVTMPVA YKEYKPHLVD 

       670        680        690        700        710        720 
QGAMLLNVSG HVKESGQVLA KQHTFRLRTP DLSLTLLGAA VVGQECGVQI VFKNPLPVTL 

       730        740        750        760        770        780 
TNVVFRLEGS GLQRPKVLNV GDIGGNETVT LRQTFVPVRP GPRQLIASLD SPQLSQVHGV 

       790        800        810 
IQVDVAPASG GSGFSDAGGD SRSGENIPMA YRGGA
Q9JLF6 in FASTA format

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