NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND TISSUE SPECIFICITY.
STRAIN=BALB/c;
DOI=10.1074/jbc.275.16.11957; PubMed=10766825 [NCBI, ExPASy, EBI, Israel, Japan]
Ariizumi K., Shen G.-L., Shikano S., Ritter R. III, Zukas P., Edelbaum D., Morita A., Takashima A.;
"Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms.";
J. Biol. Chem. 275:11957-11963(2000).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=FVB/N-3;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: May be involved in regulating immune reactivity (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Probable).

ALTERNATIVE PRODUCTS: 3 named isoforms [FASTA] produced by alternative splicing.

Name	1
Synonyms	Alpha
Isoform ID	Q9JKF4-1
This is the isoform sequence displayed in this entry.

Name	2
Synonyms	Beta
Isoform ID	Q9JKF4-2
Features which should be applied to build the isoform sequence: VSP_012846.

Name	3
Synonyms	Gamma
Isoform ID	Q9JKF4-3
Features which should be applied to build the isoform sequence: VSP_012847.

TISSUE SPECIFICITY: Expressed by the XS52 DC (dendritic cell) line (at protein level). Expressed constitutively by the epidermis, and skin resident DC appear to be the major source of this expression. Expressed in the spleen and thymus. Expression was undetectable in non-DC lines, including macrophage lines (J774 and Raw), T-cell lines (7-17, HDK-1, and D10), B-cell hybridoma (5C5), a keratinocyte line (Pam 212), and a fibroblast line (NS01).
SIMILARITY: Contains 1 C-type lectin domain.
WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Dectin-2; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_361";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF240357; AAF67177.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF240358; AAF67178.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF240359; AAF67179.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC023008; AAH23008.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00122937; -.
IPI00122939; -.
IPI00459254; -.

RefSeq

NP_064385.1; -.

UniGene

Mm.271782

3D structure databases

HSSP

Q9H8F0; 1K9J. [HSSP ENTRY / PDB]

ModBase

Q9JKF4.

Organism-specific databases

MGI

MGI:1861231; Clec4n.

Gene expression databases

Q9JKF4; -.

Q9JKF4; -.

MM_CLEC4N; -.

ENSMUSG00000023349; Mus musculus.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005529;	Molecular function: sugar binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006955;	Biological process: immune response (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002353; AntifreezeII.
IPR001304; C-type_lectin.
IPR016186; C-type_lectin-like.
IPR018378; C-type_lectin_CS.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.100.10; C-type_lectin-like; 1.

Pfam

PF00059; Lectin_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00356; ANTIFREEZEII.

SMART

SM00034; CLECT; 1.
SMART graphical view of domain structure.

PROSITE

PS00615; C_TYPE_LECTIN_1; 1.
PS50041; C_TYPE_LECTIN_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSMUSG00000023349; Mus musculus. [Contig view]

GeneID

56620; -.

KEGG

mmu:56620; -.

Phylogenomic databases

HOGENOM

Q9JKF4; -.

HOVERGEN

Q9JKF4; -.

OMA

Q9JKF4; NDVFCDS.

Other

NextBio

313047; -.

SOURCE

Clec6a; Mus musculus.

ProtoNet

Q9JKF4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Disulfide bond; Glycoprotein; Immune response; Lectin; Membrane; Signal-anchor; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 209`	`209`	`C-type lectin domain family 6 member A.`	`PRO_0000046636`
`TOPO_DOM`	`1 20`	`20`	`Cytoplasmic (Potential).`
`TRANSMEM`	`21 43`	`23`	`Signal-anchor for type II membrane protein (Potential).`
`TOPO_DOM`	`44 209`	`166`	`Extracellular (Potential).`
`DOMAIN`	`86 203`	`118`	`C-type lectin.`
`CARBOHYD`	`131 131`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`79 90`		`By similarity.`
`DISULFID`	`107 202`		`By similarity.`
`DISULFID`	`176 194`		`By similarity.`
`VAR_SEQ`	`39 72`		`Missing (in isoform 2).`	`VSP_012846`
`VAR_SEQ`	`142 182`		`Missing (in isoform 3).`	`VSP_012847`

Sequence information

Length: 209 AA [This is the length of the unprocessed precursor]

Molecular weight: 24324 Da [This is the MW of the unprocessed precursor]

CRC64: 7AB8BDC0DB1EA5ED [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVQERQSQGK GVCWTLRLWS AAVISMLLLS TCFIASCVVT YQFIMDQPSR RLYELHTYHS 

        70         80         90        100        110        120 
SLTCFSEGTM VSEKMWGCCP NHWKSFGSSC YLISTKENFW STSEQNCVQM GAHLVVINTE 

       130        140        150        160        170        180 
AEQNFITQQL NESLSYFLGL SDPQGNGKWQ WIDDTPFSQN VRFWHPHEPN LPEERCVSIV 

       190        200 
YWNPSKWGWN DVFCDSKHNS ICEMKKIYL

Q9JKF4 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools