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UniProtKB/Swiss-Prot entry Q9JH66

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NS1AB_OASV1
Primary accession number Q9JH66
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on April 8, 2008 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 28)
Name and origin of the protein
Protein name Non-structural polyprotein 1AB
Synonyms None
Contains Protein p19
Transmembrane protein 1A
Serine protease p27
     (p27)
     (EC 3.4.21.-)
Protein p20
RNA-directed RNA polymerase p57
     (p57)
     (EC 2.7.7.48)
Gene name
Name: ORF1
From
Ovine astrovirus 1 (OAstV-1) [TaxID: 70794] 
Taxonomy Viruses; ssRNA positive-strand viruses, no DNA stage; Astroviridae; Mamastrovirus.
Virus host Ovis aries (Sheep) [TaxID: 9940]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
DOI=10.1016/S0168-1702(02)00269-1; PubMed=12573498 [NCBI, ExPASy, EBI, Israel, Japan]
Jonassen C.M., Jonassen T.O., Sveen T.M., Grinde B.;
"Complete genomic sequences of astroviruses from sheep and turkey: comparison with related viruses.";
Virus Res. 91:195-201(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y15937; CAB95003.1; ALT_SEQ; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_059945.2; -.
3D structure databases
ModBase Q9JH66.
Family and domain databases
InterPro IPR007094; RNA_pol_PSvir.
Graphical view of domain structure.
PROSITE PS50507; RDRP_SSRNA_POS; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9JH66.
Genome annotation databases
GeneID 1449587; -.
Other
ProtoNet Q9JH66.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Coiled coil; Hydrolase; Membrane; Nucleotide-binding; Nucleotidyltransferase; Protease; Ribosomal frameshifting; RNA replication; RNA-directed RNA polymerase; Thiol protease; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1351  1351     Non-structural polyprotein 1AB. PRO_0000327301
CHAIN   1    172  172     Protein p19 (Potential). PRO_0000327302
CHAIN   173    407  235     Transmembrane protein 1A (Potential). PRO_0000327303
CHAIN   408    640  233     Serine protease p27 (Potential). PRO_0000327304
CHAIN   641    826  186     Protein p20 (Potential). PRO_0000327305
CHAIN   827   1351  525     RNA-directed RNA polymerase p57 (Potential). PRO_0000327306
TRANSMEM   153    173  21     Potential. 
TRANSMEM   231    251  21     Potential. 
TRANSMEM   257    277  21     Potential. 
TRANSMEM   304    324  21     Potential. 
TRANSMEM   337    357  21     Potential. 
DOMAIN   1085   1217  133     RdRp catalytic. 
COILED   105    144  40     Potential. 
COILED   579    635  57     Potential. 
ACT_SITE   452    452        Charge relay system; for serine protease activity (By similarity). 
ACT_SITE   481    481        Charge relay system; for serine protease activity (By similarity). 
ACT_SITE   544    544        Charge relay system; for serine protease activity (By similarity). 
SITE   172    173  2     Cleavage (Potential). 
SITE   407    408  2     Cleavage (Potential). 
SITE   640    641  2     Cleavage (Potential). 
SITE   826    827  2     Cleavage (Potential). 
Sequence information
Length: 1351 AA [This is the length of the unprocessed precursor] Molecular weight: 154740 Da [This is the MW of the unprocessed precursor] CRC64: FB0A954B26292C54 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNVYDKVLQF GSKKARARGM ALNKLSRNRL EDIYAGSGPL VFGFGPIDMV DPGSLNPSIK 

        70         80         90        100        110        120 
TLDTVYVAAV QPDNQYVVHH FVPGRNEWVE TDASTHQPTA LVGVLVQDHK AKTREVEDLK 

       130        140        150        160        170        180 
SQLSQLRMEH EILRHEYERL KLKSPIVKPF KPLKVLLFSL LLGLLFAGVT NGARTGTCYA 

       190        200        210        220        230        240 
YDEEKDTCLY WEWKDSREVA WYDSYVTEAL AIYNRACVYV RSKEFMTYLS LVFQTVFNWY 

       250        260        270        280        290        300 
FCATALAVYY MARAENPIVM FVTLALATLS QFQLLAVAVL PLLDFSATMG LWLSMVVFYM 

       310        320        330        340        350        360 
SQQISILVSF CVLVLSVMIG TFMADSEYAM MIKGHAVVFA IVCYSHVAMI LNIPPWVVSL 

       370        380        390        400        410        420 
TMVCYRLWRV CFVFPAERLE IRSADGKVLH TVPTHPNWTA KVTRFVQSLR KGLRTSVAPT 

       430        440        450        460        470        480 
ARIVPDGIAI VEAREGVGTC FRVKNNLVTS KHVVGSDDAV KIRWGAQEDM ARVTYRHPTK 

       490        500        510        520        530        540 
DIALMALPTN LQTMPAYKFA KAITDGPIVM TAFDEANLLL VAVTEGVRVE DHMTYSVATR 

       550        560        570        580        590        600 
NGMSGAPITT VDGRVIAVHQ TNTGFTGGAV IFVPEDIPEV RKISKREQEL EDRVKQLEGM 

       610        620        630        640        650        660 
LNMDQAYVDS NLIVDLVREA VQREMKVLRT ELANLGGFSQ KKKGKNKSTK RKRKAVWTEE 

       670        680        690        700        710        720 
EYKAMLEKGF TRDQLRIMAD AIRDQYYDDE DEQSEEEAGY PDWSDPGDST DIENEWFGYE 

       730        740        750        760        770        780 
QSWKELEPAK SGVVVNTLPK DLVFKYSLDN YPISKQDIQA VAKELKIYEK AISDIISTSV 

       790        800        810        820        830        840 
STDGKWKDDV DAQKILQELD GLWWGINHTL WEHGLMPFTQ RRKRVQQPKK LQRGPEDPGP 

       850        860        870        880        890        900 
EECKLDYWEQ LVEPSKEKFL VPPEYPLLGV VPLDRPISDF DAPVDNLLAL LPEPESPDLG 

       910        920        930        940        950        960 
FEPAVWGPEA YVKSFEKFDF ADPDPNIEKN YPREWAFANL VLHREFDFLA DSVVKDITAT 

       970        980        990       1000       1010       1020 
SKNSESTPGF PKTYWWKTEA EYLAKRGYAD YVSEWNRIRG GARPNVLWYL FLKKEILKST 

      1030       1040       1050       1060       1070       1080 
KVRDADIRQI ICSDPIFARI GCCFEEDQNE RMKRRTKTRM PQCGWSPFFG GFNDRIQRLV 

      1090       1100       1110       1120       1130       1140 
AKGNPYWIEF DWTRYDGTIP SQIFKHIKNF RFSMLAKEYQ TPELRNMYHW YVDNILRRYV 

      1150       1160       1170       1180       1190       1200 
CMPSGEITIQ HKGNPSGQVS TTMDNNLVNV FLQAFEYAYL HPEKSMDELR KDWESYDSLI 

      1210       1220       1230       1240       1250       1260 
YGDDRLTTSP SVPNDYVTRV VAMYKDIFGM WVKPEKVKVS HSPVGLSFCG FVITHQDGQY 

      1270       1280       1290       1300       1310       1320 
LPVPAEEAKL LASLLRPTKK LENMDALYGK LLCYRILNHN LPNDNKFRNY ILVALEVMAR 

      1330       1340       1350 
HYSSRGEEPP FYVTESMLDK LWRGGPKFDY G
Q9JH66 in FASTA format

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