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UniProtKB/Swiss-Prot entry Q9HR35


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNLI_HALSA
Primary accession number Q9HR35
Secondary accession numbers None
Integrated into Swiss-Prot on June 20, 2001
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name DNA ligase
Synonyms EC 6.5.1.1
Polydeoxyribonucleotide synthase [ATP]
Gene name
Name: lig
OrderedLocusNames: VNG_0881G
From
Halobacterium salinarium (Halobacterium halobium) [TaxID: 2242] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Halobacteriaceae; Halobacterium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
DOI=10.1073/pnas.190337797; PubMed=11016950 [NCBI, ExPASy, EBI, Israel, Japan]
Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S.;
"Genome sequence of Halobacterium species NRC-1.";
Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE004437; AAG19323.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G84244; G84244.
RefSeq NP_279843.1; -.
3D structure databases
ModBase Q9HR35.
Enzyme and pathway databases
BioCyc HSP64091:VNG0881G-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0003910; Molecular function: DNA ligase (ATP) activity (inferred from electronic annotation from HAMAP).
GO:0006310; Biological process: DNA recombination (inferred from electronic annotation from HAMAP).
GO:0006281; Biological process: DNA repair (inferred from electronic annotation from HAMAP).
GO:0006260; Biological process: DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00407; -; 1.
PBIL [Tree]
InterPro IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR012308; DNA_ligase_A_N.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
PF04675; DNA_ligase_A_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00574; dnl1; 1.
PROSITE PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; FALSE_NEG.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9HR35.
Genome annotation databases
GeneID 1447628; -.
GenomeReviews AE004437_GR; VNG_0881G.
KEGG hal:VNG0881G; -.
NMPDR fig|64091.1.peg.859; -.
Phylogenomic databases
HOGENOM Q9HR35; -.
Genome annotation databases
CMR Q9HR35; VNG_0881G.
Other
ProtoNet Q9HR35.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   561  561     DNA ligase. PRO_0000059602
ACT_SITE   255   255        N6-AMP-lysine intermediate (By similarity). 
Sequence information
Length: 561 AA [This is the length of the unprocessed precursor] Molecular weight: 59620 Da [This is the MW of the unprocessed precursor] CRC64: 5BB30D3C1D106D2E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKFGSFATFA ADIEATDADL DVVALVAELF DAADSDLDVV ARFVQGRVFP AHSETKLDIG 

        70         80         90        100        110        120 
PQLCYTALSR AAGRNVDADD IEARLAETGD IGAVAGSLDL GGQTGLAAFG GGDDHADGLT 

       130        140        150        160        170        180 
VSGVADELAA LAAAAGDGSQ SEKVTLLFGL FNQCTSREAR YLARLVLGEM RIGVGEGAVR 

       190        200        210        220        230        240 
DAIAEAFDVP TAAVQRALQV SNDYGLVAET ARDSGTDALD AMGLEVGRPV QAMLAQAGTV 

       250        260        270        280        290        300 
TDALDEWHEA AVETKFDGAR VQVHYDGDDV VLYSRNMENV TGALPELVEF VENNVTAPVI 

       310        320        330        340        350        360 
IDGEAVAADE DGDPLPFQEI LKRFRRKHDV AAMREEISVE LHAFDCLHAP SADGGEDLLD 

       370        380        390        400        410        420 
APFSDRHRRL RSVVDDASAV SEVLVTDDAD EIAAFEATAL EGGHEGIMLK NPAAPYTPGD 

       430        440        450        460        470        480 
RGKDWLKRKP DVETLDLVVT GAEWGEGRRA SVLGTFLLSA RDAAGDGFET IGKVATGLTD 

       490        500        510        520        530        540 
EELAALSDRL EPHVRSEDGQ TVDIEPAVVL EVGYEEIQAS PTYSSGYALR FPRFVSVRED 

       550        560 
KTPTTADTIE RVERLAAQQQ Q 

Q9HR35 in FASTA format

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