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UniProtKB/Swiss-Prot entry Q9HMH9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_HALSA
Primary accession number Q9HMH9
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 2003
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 48)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: VNG_2533G
From
Halobacterium salinarium (Halobacterium halobium) [TaxID: 2242] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Halobacteriaceae; Halobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
DOI=10.1073/pnas.190337797; PubMed=11016950 [NCBI, ExPASy, EBI, Israel, Japan]
Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S.;
"Genome sequence of Halobacterium species NRC-1.";
Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE004437; AAG20592.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D84403; D84403.
RefSeq NP_281112.1; -.
3D structure databases
HSSP P81006; 1GKR. [HSSP ENTRY / PDB]
ModBase Q9HMH9.
Enzyme and pathway databases
BioCyc HSP64091:VNG2533G-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q9HMH9.
Genome annotation databases
GeneID 1448897; -.
GenomeReviews AE004437_GR; VNG_2533G.
KEGG hal:VNG2533G; -.
NMPDR fig|64091.1.peg.2139; -.
Phylogenomic databases
HOGENOM Q9HMH9; -.
Genome annotation databases
CMR Q9HMH9; VNG_2533G.
Other
ProtoNet Q9HMH9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   422  422     Dihydroorotase. PRO_0000147268
METAL   53    53        Zinc 1 (By similarity). 
METAL   55    55        Zinc 1 (By similarity). 
METAL   172   172        Zinc 2 (By similarity). 
METAL   223   223        Zinc 2 (By similarity). 
METAL   291   291        Zinc 1 (By similarity). 
Sequence information
Length: 422 AA [This is the length of the unprocessed precursor] Molecular weight: 44817 Da [This is the MW of the unprocessed precursor] CRC64: C055ADECC6E34125 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRVIRDAVLA DGRVRDIRLD GERIDAVGTA LDGELFVDAN ADYRVLPGMI DAHVHFRQPG 

        70         80         90        100        110        120 
FEHKETWASG SRSAAAGGVT TVVDQPNTAP PTVTGDAVDE KAAHAAADSV VDWGVNGGVT 

       130        140        150        160        170        180 
GEWDPASLFD RSLFALGEVF LADSTGDMGI DAALFRDACQ RAASEDVVVT VHAEDADRFD 

       190        200        210        220        230        240 
TAAKSRSDAD AWSAYRTPEA EAAAVERAVE VGTEAGATIH IAHTSTPEGV DAAAAGGATC 

       250        260        270        280        290        300 
EATPHHLFLS RDDLDDLGTF GRMNPPLRSD PRREALFERL ADGRIDVVAT DHAPHTRAEK 

       310        320        330        340        350        360 
AADIWDAPSG VPGVETALPL LLGAAHRGEL SYERVRDVTA ANPADVFGLE RKGHIAAGRD 

       370        380        390        400        410        420 
ADLVLVDPDD AREIHGDDLH SNCEWTPFEG HVGVFPAMTL VRGTTVWDGD TVSAFDGRNV 


RQ
Q9HMH9 in FASTA format

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