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UniProtKB/Swiss-Prot entry Q9HB63


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NET4_HUMAN
Primary accession number Q9HB63
Secondary accession numbers Q658K9 Q7L3F1 Q7L9D6 Q7Z5B6 Q9BZP1 Q9NT44 Q9P133
Integrated into Swiss-Prot on September 27, 2005
Sequence was last modified on September 27, 2005 (Sequence version 2)
Annotations were last modified on    June 10, 2008 (Entry version 47)
Name and origin of the protein
Protein name Netrin-4 [Precursor]
Synonyms Beta-netrin
Hepar-derived netrin-like protein
Gene name
Name: NTN4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1083/jcb.151.2.221; PubMed=11038171 [NCBI, ExPASy, EBI, Israel, Japan]
Koch M., Murrell J.R., Hunter D.D., Olson P.F., Jin W., Keene D.R., Brunken W.J., Burgeson R.E.;
"A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin. Identification, expression, and functional characterization.";
J. Cell Biol. 151:221-234(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Niranjan B., Hohenester E., Slade M., Ali S., Kamalati T., Buluwela L.;
"Identification of a novel member of the netrin family, which is induced during in vitro mammary tubule morphogenesis.";
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
TISSUE=Fetal liver;
Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.;
"Hetrin, an alternative splicing form of beta-netrin.";
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Li H., Zhou G., Shen C., Li M., Xiao W., Zhong G., Zheng G., Yu R., Ke R., Zhong J., Huang F., Lin L., Yang S.;
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-628 (ISOFORMS 1/3).
TISSUE=Stomach;
The German cDNA consortium;
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-628 (ISOFORMS 1/3).
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 288-628 (ISOFORMS 1/3).
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF278532; AAG30822.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF297711; AAG53651.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF119916; AAF69670.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY330211; AAP92113.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL137540; CAB70800.3; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL833767; CAH56243.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC013591; AAH13591.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK024691; BAB14964.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T46383; T46383.
RefSeq NP_067052.2; -.
UniGene Hs.201034
3D structure databases
HSSP P02468; 1NPE. [HSSP ENTRY / PDB]
ModBase Q9HB63.
Organism-specific databases
H-InvDB HIX0010897; -.
HGNC HGNC:13658; NTN4.
GeneLynx NTN4; Homo sapiens.
GenAtlas NTN4.
MIM 610401; gene. [NCBI / EBI]
PharmGKB PA26688; -.
GeneCards Q9HB63.
Gene expression databases
ArrayExpress Q9HB63; -.
CleanEx HS_NTN4; -.
GermOnline ENSG00000074527; Homo sapiens.
Family and domain databases
InterPro IPR002049; EGF_laminin.
IPR013032; EGF_like_reg_CS.
IPR008211; Laminin_N.
IPR001134; Netrin_C.
Graphical view of domain structure.
Pfam PF00053; Laminin_EGF; 3.
PF00055; Laminin_N; 1.
PF01759; NTR; 1.
Pfam graphical view of domain structure.
PRINTS PR00011; EGFLAMININ.
SMART SM00643; C345C; 1.
SM00180; EGF_Lam; 3.
SM00136; LamNT; 1.
SMART graphical view of domain structure.
PROSITE PS00022; EGF_1; 2.
PS01248; EGF_LAM_1; 2.
PS50027; EGF_LAM_2; 3.
PS51117; LAMININ_NTER; 1.
PS50189; NTR; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9HB63.
Genome annotation databases
Ensembl ENSG00000074527; Homo sapiens. [Contig view]
GeneID 59277; -.
KEGG hsa:59277; -.
Phylogenomic databases
HOVERGEN Q9HB63; -.
Other
SOURCE NTN4; Homo sapiens.
ProtoNet Q9HB63.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Basement membrane; Extracellular matrix; Glycoprotein; Laminin EGF-like domain; Polymorphism; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     Potential. 
CHAIN   19   628  610     Netrin-4. PRO_0000042116
DOMAIN   30   261  232     Laminin N-terminal. 
DOMAIN   262   331  70     Laminin EGF-like 1. 
DOMAIN   332   394  63     Laminin EGF-like 2. 
DOMAIN   395   448  54     Laminin EGF-like 3. 
DOMAIN   506   627  122     NTR. 
CARBOHYD   56    56        N-linked (GlcNAc...) (Potential). 
CARBOHYD   163   163        N-linked (GlcNAc...) (Potential). 
CARBOHYD   353   353        N-linked (GlcNAc...) (Potential). 
CARBOHYD   483   483        N-linked (GlcNAc...) (Potential). 
DISULFID   262   271        By similarity. 
DISULFID   264   293        By similarity. 
DISULFID   295   304        By similarity. 
DISULFID   307   329        By similarity. 
DISULFID   332   341        By similarity. 
DISULFID   334   359        By similarity. 
DISULFID   362   371        By similarity. 
DISULFID   374   392        By similarity. 
DISULFID   395   413        By similarity. 
DISULFID   397   420        By similarity. 
DISULFID   422   431        By similarity. 
DISULFID   434   446        By similarity. 
DISULFID   506   576        By similarity. 
DISULFID   520   627        By similarity. 
VAR_SEQ   1    37        Missing (in isoform 3). VSP_015745
VAR_SEQ   504   526        Missing (in isoform 2). VSP_015746
VARIANT   205   205  1     Y -> H (in dbSNP:rs17288108 [NCBI]). VAR_023548 
CONFLICT   68    68        T -> K (in Ref. 1; AAG30822). 
CONFLICT   161   161        A -> G (in Ref. 3; AAF69670). 
CONFLICT   222   222        T -> I (in Ref. 4; AAP92113). 
CONFLICT   331   331        T -> A (in Ref. 1 and 4). 
CONFLICT   462   462        C -> R (in Ref. 4; AAP92113). 
CONFLICT   472   472        Y -> C (in Ref. 1; AAG30822). 
CONFLICT   472   472        Y -> H (in Ref. 4; AAP92113). 
CONFLICT   545   545        N -> S (in Ref. 4; AAP92113). 
Sequence information
Length: 628 AA [This is the length of the unprocessed precursor] Molecular weight: 70071 Da [This is the MW of the unprocessed precursor] CRC64: 275613B63A39B267 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGSCARLLLL WGCTVVAAGL SGVAGVSSRC EKACNPRMGN LALGRKLWAD TTCGQNATEL 

        70         80         90        100        110        120 
YCFYSENTDL TCRQPKCDKC NAAYPHLAHL PSAMADSSFR FPRTWWQSAE DVHREKIQLD 

       130        140        150        160        170        180 
LEAEFYFTHL IVMFKSPRPA AMVLDRSQDF GKTWKPYKYF ATNCSATFGL EDDVVKKGAI 

       190        200        210        220        230        240 
CTSKYSSPFP CTGGEVIFKA LSPPYDTENP YSAKVQEQLK ITNLRVQLLK RQSCPCQRND 

       250        260        270        280        290        300 
LNEEPQHFTH YAIYDFIVKG SCFCNGHADQ CIPVHGFRPV KAPGTFHMVH GKCMCKHNTA 

       310        320        330        340        350        360 
GSHCQHCAPL YNDRPWEAAD GKTGAPNECR TCKCNGHADT CHFDVNVWEA SGNRSGGVCD 

       370        380        390        400        410        420 
DCQHNTEGQY CQRCKPGFYR DLRRPFSAPD ACKPCSCHPV GSAVLPANSV TFCDPSNGDC 

       430        440        450        460        470        480 
PCKPGVAGRR CDRCMVGYWG FGDYGCRPCD CAGSCDPITG DCISSHTDID WYHEVPDFRP 

       490        500        510        520        530        540 
VHNKSEPAWE WEDAQGFSAL LHSGKCECKE QTLGNAKAFC GMKYSYVLKI KILSAHDKGT 

       550        560        570        580        590        600 
HVEVNVKIKK VLKSTKLKIF RGKRTLYPES WTDRGCTCPI LNPGLEYLVA GHEDIRTGKL 

       610        620 
IVNMKSFVQH WKPSLGRKVM DILKRECK 

Q9HB63 in FASTA format

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