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UniProtKB/Swiss-Prot entry Q9H8L6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MMRN2_HUMAN
Primary accession number Q9H8L6
Secondary accession numbers Q504V7 Q6P2N2
Integrated into Swiss-Prot on October 3, 2003
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 68)
Name and origin of the protein
Protein name Multimerin-2 [Precursor]
Synonyms EMILIN-3
Elastin microfibril interface located protein 3
Elastin microfibril interfacer 3
EndoGlyx-1 p125/p140 subunit
Gene name
Name: MMRN2
Synonyms: EMILIN3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
DOI=10.1074/jbc.M106152200; PubMed=11559704 [NCBI, ExPASy, EBI, Israel, Japan]
Christian S., Ahorn H., Novatchkova M., Garin-Chesa P., Park J.E., Weber G., Eisenhaber F., Rettig W.J., Lenter M.C.;
"Molecular cloning and characterization of EndoGlyx-1, an EMILIN-like multisubunit glycoprotein of vascular endothelium.";
J. Biol. Chem. 276:48588-48595(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-49.
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-845, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0502065; PubMed=16335952 [NCBI, ExPASy, EBI, Israel, Japan]
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
[5]
VARIANT [LARGE SCALE ANALYSIS] MET-448.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK023527; BAB14599.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC064415; AAH64415.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC094744; AAH94744.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00015525; -.
RefSeq NP_079032.2; -.
UniGene Hs.524479
3D structure databases
ModBase Q9H8L6.
Organism-specific databases
GeneCards GC10M088685; -.
H-InvDB HIX0008998; -.
HGNC HGNC:19888; MMRN2.
GenAtlas MMRN2.
MIM 608925; gene. [NCBI / EBI]
PharmGKB PA134991578; -.
Gene expression databases
ArrayExpress Q9H8L6; -.
Bgee Q9H8L6; -.
CleanEx HS_EMILIN3; -.
HS_MMRN2; -.
GermOnline ENSG00000173269; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from expression pattern from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001073; C1q.
IPR011489; EMI_domain.
IPR008983; Tumour_necrosis_fac-like.
Graphical view of domain structure.
Gene3D G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1.
Pfam PF00386; C1q; 1.
PF07546; EMI; 1.
Pfam graphical view of domain structure.
PRINTS PR00007; COMPLEMNTC1Q.
PROSITE PS50871; C1Q; 1.
PS51041; EMI; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9H8L6; -.
Genome annotation databases
Ensembl ENSG00000173269; Homo sapiens. [Contig view]
GeneID 79812; -.
KEGG hsa:79812; -.
Phylogenomic databases
HOGENOM Q9H8L6; -.
HOVERGEN Q9H8L6; -.
Other
NextBio 69406; -.
SOURCE MMRN2; Homo sapiens.
ProtoNet Q9H8L6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Coiled coil; Disulfide bond; Extracellular matrix; Glycoprotein; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    22  22     Potential. 
CHAIN   23   949  927     Multimerin-2. PRO_0000007822
DOMAIN   54   132  79     EMI. 
DOMAIN   821   949  129     C1q. 
COILED   167   187  21     Potential. 
COILED   292   487  196     Potential. 
COILED   547   596  50     Potential. 
COILED   688   711  24     Potential. 
COMPBIAS   779   806  28     Arg/Asp/Glu/Lys-rich (highly charged). 
CARBOHYD   205   205        N-linked (GlcNAc...) (Potential). 
CARBOHYD   214   214        N-linked (GlcNAc...) (Potential). 
CARBOHYD   249   249        N-linked (GlcNAc...) (Potential). 
CARBOHYD   261   261        N-linked (GlcNAc...) (Potential). 
CARBOHYD   350   350        N-linked (GlcNAc...) (Potential). 
CARBOHYD   379   379        N-linked (GlcNAc...) (Potential). 
CARBOHYD   439   439        N-linked (GlcNAc...) (Potential). 
CARBOHYD   472   472        N-linked (GlcNAc...) (Potential). 
CARBOHYD   727   727        N-linked (GlcNAc...) (Potential). 
CARBOHYD   765   765        N-linked (GlcNAc...) (Potential). 
CARBOHYD   845   845        N-linked (GlcNAc...). 
DISULFID   58   122        By similarity. 
DISULFID   85    92        By similarity. 
DISULFID   121   130        By similarity. 
VARIANT   49    49  1     S -> G (in dbSNP:rs3750823 [NCBI]). VAR_019801 
VARIANT   448   448  1     V -> M (in a colorectal cancer sample; somatic mutation). VAR_036362 
VARIANT   731   731  1     D -> H (in dbSNP:rs4934281 [NCBI]). VAR_019802 
VARIANT   831   831  1     S -> R (in dbSNP:rs36073867 [NCBI]). VAR_053076 
VARIANT   910   910  1     V -> L (in dbSNP:rs34587013 [NCBI]). VAR_053077 
CONFLICT   270   270        R -> H (in Ref. 1; AAH64415). 
Sequence information
Length: 949 AA [This is the length of the unprocessed precursor] Molecular weight: 104417 Da [This is the MW of the unprocessed precursor] CRC64: CD6308AC0EEAF911 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MILSLLFSLG GPLGWGLLGA WAQASSTSLS DLQSSRTPGV WKAEAEDTSK DPVGRNWCPY 

        70         80         90        100        110        120 
PMSKLVTLLA LCKTEKFLIH SQQPCPQGAP DCQKVKVMYR MAHKPVYQVK QKVLTSLAWR 

       130        140        150        160        170        180 
CCPGYTGPNC EHHDSMAIPE PADPGDSHQE PQDGPVSFKP GHLAAVINEV EVQQEQQEHL 

       190        200        210        220        230        240 
LGDLQNDVHR VADSLPGLWK ALPGNLTAAV MEANQTGHEF PDRSLEQVLL PHVDTFLQVH 

       250        260        270        280        290        300 
FSPIWRSFNQ SLHSLTQAIR NLSLDVEANR QAISRVQDSA VARADFQELG AKFEAKVQEN 

       310        320        330        340        350        360 
TQRVGQLRQD VEDRLHAQHF TLHRSISELQ ADVDTKLKRL HKAQEAPGTN GSLVLATPGA 

       370        380        390        400        410        420 
GARPEPDSLQ ARLGQLQRNL SELHMTTARR EEELQYTLED MRATLTRHVD EIKELYSESD 

       430        440        450        460        470        480 
ETFDQISKVE RQVEELQVNH TALRELRVIL MEKSLIMEEN KEEVERQLLE LNLTLQHLQG 

       490        500        510        520        530        540 
GHADLIKYVK DCNCQKLYLD LDVIREGQRD ATRALEETQV SLDERRQLDG SSLQALQNAV 

       550        560        570        580        590        600 
DAVSLAVDAH KAEGERARAA TSRLRSQVQA LDDEVGALKA AAAEARHEVR QLHSAFAALL 

       610        620        630        640        650        660 
EDALRHEAVL AALFGEEVLE EMSEQTPGPL PLSYEQIRVA LQDAASGLQE QALGWDELAA 

       670        680        690        700        710        720 
RVTALEQASE PPRPAEHLEP SHDAGREEAA TTALAGLARE LQSLSNDVKN VGRCCEAEAG 

       730        740        750        760        770        780 
AGAASLNASL DGLHNALFAT QRSLEQHQRL FHSLFGNFQG LMEANVSLDL GKLQTMLSRK 

       790        800        810        820        830        840 
GKKQQKDLEA PRKRDKKEAE PLVDIRVTGP VPGALGAALW EAGSPVAFYA SFSEGTAALQ 

       850        860        870        880        890        900 
TVKFNTTYIN IGSSYFPEHG YFRAPERGVY LFAVSVEFGP GPGTGQLVFG GHHRTPVCTT 

       910        920        930        940 
GQGSGSTATV FAMAELQKGE RVWFELTQGS ITKRSLSGTA FGGFLMFKT 

Q9H8L6 in FASTA format

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