[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY. DOI=10.1074/jbc.M005432200; PubMed=11010966 [NCBI, ExPASy, EBI, Israel, Japan] Yousef G.M., Scorilas A., Jung K., Ashworth L.K., Diamandis E.P.; "Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer."; J. Biol. Chem. 276:53-61(2001).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/S0378-1119(00)00382-6; PubMed=11054574 [NCBI, ExPASy, EBI, Israel, Japan] Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.; "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."; Gene 257:119-130(2000).
[3]	PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Brain; DOI=10.1016/0167-4781(94)90018-3; PubMed=8018728 [NCBI, ExPASy, EBI, Israel, Japan] Dihanich M.E., Spiess M.; "A novel serine proteinase-like sequence from human brain."; Biochim. Biophys. Acta 1218:225-228(1994).
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[5]	SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S). DOI=10.1186/gb-2004-5-2-r8; PubMed=14759258 [NCBI, ExPASy, EBI, Israel, Japan] Hillman R.T., Green R.E., Brenner S.E.; "An unappreciated role for RNA surveillance."; Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
[6]	VARIANT [LARGE SCALE ANALYSIS] THR-137. DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan] Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.; "The consensus coding sequences of human breast and colorectal cancers."; Science 314:268-274(2006).

Comments

FUNCTION: Protease whose physiological substrate is not yet known.
SUBCELLULAR LOCATION: Secreted (Probable).

ALTERNATIVE PRODUCTS: 4 named isoforms [FASTA] produced by alternative splicing.

Name	1
Isoform ID	Q9H2R5-1
This is the isoform sequence displayed in this entry.

Name	2
Isoform ID	Q9H2R5-2
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Features which should be applied to build the isoform sequence: VSP_005405.

Name	3
Isoform ID	Q9H2R5-3
Features which should be applied to build the isoform sequence: VSP_005406, VSP_005407.

Name	4
Isoform ID	Q9H2R5-4
Features which should be applied to build the isoform sequence: VSP_005404.

TISSUE SPECIFICITY: Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.
SIMILARITY: Belongs to the peptidase S1 family. Kallikrein subfamily [view classification].
SIMILARITY: Contains 1 peptidase S1 domain [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF242195; AAG09469.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF242195; AAG09470.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF242195; AAG09471.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF242195; AAG09472.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF243527; AAG33354.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X75363; CAA53145.1; ALT_SEQ; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069507; AAH69507.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC126137; AAI26138.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00033970; -.
IPI00150552; -.
IPI00219692; -.
IPI00219693; -.

S45356; S45356.

NP_059979.2; -.

3D structure databases

HSSP

P00760; 1EZX. [HSSP ENTRY / PDB]

ModBase

Q9H2R5.

Protein family/group databases

MEROPS

S01.081; -.

Organism-specific databases

GC19M056020; -.

HIX0039991; -.

HGNC:20453; KLK15.

610601; gene. [NCBI / EBI]

PharmGKB

PA134977502; -.

Gene expression databases

Q9H2R5; -.

Q9H2R5; -.

HS_KLK15; -.

ENSG00000174562; Homo sapiens.

Ontologies

GO:0005576;	Cellular component: extracellular region (non-traceable author statement from UniProtKB).
GO:0004252;	Molecular function: serine-type endopeptidase activity (non-traceable author statement from UniProtKB).
GO:0006508;	Biological process: proteolysis (non-traceable author statement from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR018114; Peptidase_S1/S6_AS.
IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.

Pfam

PF00089; Trypsin; 1.
Pfam graphical view of domain structure.

PRINTS

PR00722; CHYMOTRYPSIN.

SMART

SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.

PROSITE

PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q9H2R5; -.

Genome annotation databases

Ensembl

ENSG00000174562; Homo sapiens. [Contig view]

GeneID

55554; -.

KEGG

hsa:55554; -.

Phylogenomic databases

HOVERGEN

Q9H2R5; -.

OMA

Q9H2R5; PGEACVV.

Other

60018; -.

KLK15; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Disulfide bond; Glycoprotein; Hydrolase; Polymorphism; Protease; Secreted; Serine protease; Signal; Zymogen.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 16`	`16`	`Potential.`
`PROPEP`	`17 21`	`5`	`Activation peptide (Potential).`	`PRO_0000027960`
`CHAIN`	`22 256`	`235`	`Kallikrein-15.`	`PRO_0000027961`
`DOMAIN`	`22 254`	`233`	`Peptidase S1.`
`ACT_SITE`	`62 62`		`Charge relay system (By similarity).`
`ACT_SITE`	`106 106`		`Charge relay system (By similarity).`
`ACT_SITE`	`209 209`		`Charge relay system (By similarity).`
`CARBOHYD`	`171 171`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`232 232`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`47 63`		`By similarity.`
`DISULFID`	`138 215`		`By similarity.`
`DISULFID`	`180 194`		`By similarity.`
`DISULFID`	`205 230`		`By similarity.`
`VAR_SEQ`	`122 256`		`Missing (in isoform 2).`	`VSP_005405`
`VAR_SEQ`	`122 206`		`Missing (in isoform 4).`	`VSP_005404`
`VAR_SEQ`	`161 161`		`V -> G (in isoform 3).`	`VSP_005406`
`VAR_SEQ`	`162 256`		`Missing (in isoform 3).`	`VSP_005407`
`VARIANT`	`134 134`	`1`	`P -> L (in dbSNP:rs3212805 [NCBI]).`	`VAR_020179`
`VARIANT`	`137 137`	`1`	`A -> T (in a breast cancer sample; somatic mutation).`	`VAR_036298`
`CONFLICT`	`147 160`		`SHNEPGTAGSPRSQ -> PLSSP (in Ref. 2).`

Sequence information

Length: 256 AA [This is the length of the unprocessed precursor]

Molecular weight: 28087 Da [This is the MW of the unprocessed precursor]

CRC64: B5EBF8D6022786B5 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MWLLLTLSFL LASTAAQDGD KLLEGDECAP HSQPWQVALY ERGRFNCGAS LISPHWVLSA 

        70         80         90        100        110        120 
AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA RSHRNDIMLL RLVQPARLNP 

       130        140        150        160        170        180 
QVRPAVLPTR CPHPGEACVV SGWGLVSHNE PGTAGSPRSQ VSLPDTLHCA NISIISDTSC 

       190        200        210        220        230        240 
DKSYPGRLTN TMVCAGAEGR GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT 

       250 
KVCHYLEWIR ETMKRN

Q9H2R5 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools