[1]	NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, AND VARIANT LYS-88. TISSUE=Spleen; DOI=10.1093/nar/30.4.993; PubMed=11842111 [NCBI, ExPASy, EBI, Israel, Japan] Rothenburg S., Schwartz T., Koch-Nolte F., Haag F.; "Complex regulation of the human gene for the Z-DNA binding protein DLM-1."; Nucleic Acids Res. 30:993-1000(2002).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan] Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.; "The DNA sequence and comparative analysis of human chromosome 20."; Nature 414:865-871(2001).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). TISSUE=Blood; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: May play a role in host defense against tumors and pathogens. Binds Z-DNA (By similarity).

ALTERNATIVE PRODUCTS: 5 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist.

Name	1
Isoform ID	Q9H171-1
This is the isoform sequence displayed in this entry.

Name	2
Isoform ID	Q9H171-2
Features which should be applied to build the isoform sequence: VSP_004081.

Name	3
Isoform ID	Q9H171-3
Features which should be applied to build the isoform sequence: VSP_004082.

Name	4
Isoform ID	Q9H171-4
Features which should be applied to build the isoform sequence: VSP_004078.

Name	5
Isoform ID	Q9H171-5
Features which should be applied to build the isoform sequence: VSP_004079, VSP_004080.

TISSUE SPECIFICITY: Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.
SIMILARITY: Contains 2 DRADA repeats.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ300575; CAC18810.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AL035541; CAI23107.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC028218; AAH28218.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00006512; -.
IPI00181608; -.
IPI00219702; -.
IPI00219704; -.
IPI00334653; -.

RefSeq

NP_110403.1; -.

UniGene

Hs.302123

3D structure databases

PDB

3EYI; X-ray; 1.45 A; A/B=103-166.

[ExPASy / RCSB / EBI]

3EYI; -.

PTM databases

Q9H171; -.

Organism-specific databases

GC20M055602; -.

HGNC:16176; ZBP1.

606750; gene. [NCBI / EBI]

PharmGKB

PA38094; -.

Gene expression databases

Q9H171; -.

Q9H171; -.

HS_ZBP1; -.

ENSG00000124256; Homo sapiens.

Ontologies

GO:0003726;	Molecular function: double-stranded RNA adenosine deaminase activity (inferred from electronic annotation from InterPro).
GO:0003692;	Molecular function: left-handed Z-DNA binding (non-traceable author statement from UniProtKB).
GO:0003723;	Molecular function: RNA binding (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000607; dsRNA_A_deaminase.
IPR011991; Wing_hlx_DNA_bd.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.

Pfam

PF02295; z-alpha; 2.
Pfam graphical view of domain structure.

PROSITE

PS50139; DRADA_REPEAT; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q9H171; -.

Genome annotation databases

Ensembl

ENSG00000124256; Homo sapiens. [Contig view]

GeneID

81030; -.

KEGG

hsa:81030; -.

Phylogenomic databases

HOVERGEN

Q9H171; -.

OMA

Q9H171; HYVDEAS.

Other

71358; -.

ZBP1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Alternative splicing; DNA-binding; Polymorphism; Repeat.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 429`	`429`	`Z-DNA-binding protein 1.`	`PRO_0000066564`
`REPEAT`	`6 72`	`67`	`DRADA 1.`
`REPEAT`	`103 168`	`66`	`DRADA 2.`
`VAR_SEQ`	`87 149`		`AERPQQHAATIPETPGPQFSQQREEDIYRFLKDNGPQRAL` `VIAQALGMRTAKDVNRDLYRMKS -> GNCHPGEAGLTLQGASWQWTSTDLSLGSNLNSATWELTGF` `LSLCLGFFFWLMELTAGLLGRGC (in isoform 5).`	`VSP_004079`
`VAR_SEQ`	`87 109`		`Missing (in isoform 4).`	`VSP_004078`
`VAR_SEQ`	`150 429`		`Missing (in isoform 5).`	`VSP_004080`
`VAR_SEQ`	`365 429`		`GRRPADTQSRSHFPRDIGQPITPSHSKLTPKLETMTLGNR` `SHKAAEGSHYVDEASHEGSWWGGGI -> VAAFTEVLNPSKSFMKFGINFFQTPVNVDSLTSSHESQMF` `LTACRLVIFSRRFSTYFAQIHLRNHSVLHLCPHKIYL` `LKNKK (in isoform 2).`	`VSP_004081`
`VAR_SEQ`	`365 429`		`GRRPADTQSRSHFPRDIGQPITPSHSKLTPKLETMTLGNR` `SHKAAEGSHYVDEASHEGSWWGGGI -> GRRPADTQSRSFDGQE (in isoform 3).`	`VSP_004082`
`VARIANT`	`17 17`	`1`	`R -> I (in dbSNP:rs35813125 [NCBI]).`	`VAR_057030`
`VARIANT`	`70 70`	`1`	`G -> R (in dbSNP:rs34964609 [NCBI]).`	`VAR_057031`
`VARIANT`	`88 88`	`1`	`E -> K (in dbSNP:rs2073145 [NCBI]).`	`VAR_014316`
`VARIANT`	`154 154`	`1`	`D -> H (in dbSNP:rs16981187 [NCBI]).`	`VAR_057032`
`VARIANT`	`166 166`	`1`	`R -> H (in dbSNP:rs34478944 [NCBI]).`	`VAR_057033`
`CONFLICT`	`258 258`		`Q -> R (in Ref. 1; CAC18810).`

Sequence information

Length: 429 AA [This is the length of the unprocessed precursor]

Molecular weight: 46343 Da [This is the MW of the unprocessed precursor]

CRC64: 2C9B195112822991 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAQAPADPGR EGHLEQRILQ VLTEAGSPVK LAQLVKECQA PKRELNQVLY RMKKELKVSL 

        70         80         90        100        110        120 
TSPATWCLGG TDPEGEGPAE LALSSPAERP QQHAATIPET PGPQFSQQRE EDIYRFLKDN 

       130        140        150        160        170        180 
GPQRALVIAQ ALGMRTAKDV NRDLYRMKSR HLLDMDEQSK AWTIYRPEDS GRRAKSASII 

       190        200        210        220        230        240 
YQHNPINMIC QNGPNSWISI ANSEAIQIGH GNIITRQTVS REDGSAGPRH LPSMAPGDSS 

       250        260        270        280        290        300 
TWGTLVDPWG PQDIHMEQSI LRRVQLGHSN EMRLHGVPSE GPAHIPPGSP PVSATAAGPE 

       310        320        330        340        350        360 
ASFEARIPSP GTHPEGEAAQ RIHMKSCFLE DATIGNSNKM SISPGVAGPG GVAGSGEGEP 

       370        380        390        400        410        420 
GEDAGRRPAD TQSRSHFPRD IGQPITPSHS KLTPKLETMT LGNRSHKAAE GSHYVDEASH 


EGSWWGGGI

Q9H171 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools