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UniProtKB/Swiss-Prot entry Q9ERE9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name JIP2_MOUSE
Primary accession number Q9ERE9
Secondary accession number Q9CXI4
Integrated into Swiss-Prot on December 5, 2001
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 57)
Name and origin of the protein
Protein name C-jun-amino-terminal kinase-interacting protein 2
Synonyms JNK-interacting protein 2
JIP-2
JNK MAP kinase scaffold protein 2
Islet-brain-2
IB-2
Mitogen-activated protein kinase 8-interacting protein 2
Gene name
Name: Mapk8ip2
Synonyms: Ib2, Jip2
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH APOER2.
STRAIN=BALB/c;
TISSUE=Brain;
DOI=10.1074/jbc.M004119200; PubMed=10827199 [NCBI, ExPASy, EBI, Israel, Japan]
Stockinger W., Brandes C., Fasching D., Hermann M., Gotthardt M., Herz J., Schneider W.J., Nimpf J.;
"The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2.";
J. Biol. Chem. 275:25625-25632(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Embryonic head;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF310135; AAG31800.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK014339; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
UniGene Mm.173337
3D structure databases
SMR Q9ERE9; 612-666.
ModBase Q9ERE9.
Protein-protein interaction databases
IntAct Q9ERE9; -.
PTM databases
PhosphoSite Q9ERE9; -.
Organism-specific databases
MGI MGI:1926555; Mapk8ip2.
Gene expression databases
ArrayExpress Q9ERE9; -.
GermOnline ENSMUSG00000022619; Mus musculus.
Ontologies
GO
GO:0043025; Cellular component: cell soma (inferred from direct assay from MGI).
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0019894; Molecular function: kinesin binding (inferred from physical interaction from UniProtKB).
GO:0019901; Molecular function: protein kinase binding (inferred from sequence or structural similarity from UniProtKB).
GO:0046328; Biological process: regulation of JNK cascade (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR011993; PH_type.
IPR006020; PTB_PID.
IPR001452; SH3.
Graphical view of domain structure.
Gene3D G3DSA:2.30.29.30; PH_type; 1.
Pfam PF00640; PID; 1.
PF00018; SH3_1; 1.
Pfam graphical view of domain structure.
SMART SM00462; PTB; 1.
SM00326; SH3; 1.
SMART graphical view of domain structure.
PROSITE PS01179; PID; 1.
PS50002; SH3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9ERE9.
Genome annotation databases
Ensembl ENSMUSG00000022619; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM Q9ERE9; -.
HOVERGEN Q9ERE9; -.
Other
SOURCE Mapk8ip2; Mus musculus.
ProtoNet Q9ERE9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; SH3 domain.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   830  830     C-jun-amino-terminal kinase-interacting protein 2. PRO_0000220632
DOMAIN   610   671  62     SH3. 
DOMAIN   683   819  137     PID. 
REGION   111   278  168     JNK-binding domain (JBD). 
COMPBIAS   30    36  7     Asp/Glu-rich (acidic). 
COMPBIAS   85   104  20     Asp/Glu-rich (acidic). 
COMPBIAS   154   157  4     Poly-Asn. 
COMPBIAS   282   293  12     Ser-rich. 
COMPBIAS   420   437  18     Pro-rich. 
COMPBIAS   472   487  16     Asp/Glu-rich (acidic). 
CONFLICT   216   216        P -> Q (in Ref. 2; AK014339). 
Sequence information
Length: 830 AA [This is the length of the unprocessed precursor] Molecular weight: 89900 Da [This is the MW of the unprocessed precursor] CRC64: 7EC8EAD19A90163C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY DSDHCEKDSL 

        70         80         90        100        110        120 
SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DDEEEEEEEE EEEDGDRQGK AGGGPGSQAL 

       130        140        150        160        170        180 
AGDSLIPSPS LEESHKLRPT TLHLTTLGAQ DSLNNNNGGF TSAPPSSWQE TVLRSPAQEP 

       190        200        210        220        230        240 
LKELPAPLLP AEEERHEVQS LARPGCDCEG NQPPEPPASS GGASPSSDPG IEADLRSHSS 

       250        260        270        280        290        300 
GGHEGRRSSQ ELSSPGSDSE DAGGARLGRM ISSISETELE LSSDGGSSSG RSSHLTNSIE 

       310        320        330        340        350        360 
EASSPASEPE PEPEPLHEPP RRPAFLPVGQ DDTNSEYESG SESEPDLSED ADSPWLLSNL 

       370        380        390        400        410        420 
VSRMISEGSS PIRCPGQCLS PAPRLPEEAA SQANSVPQDC QDPEAGPHVE LVDMDTLCGP 

       430        440        450        460        470        480 
PPPAPAAPRL GPAQPGPCLF LSNPTRDTIT PLWATPGRTA RPGRSCSAAC SEEEEEDEEE 

       490        500        510        520        530        540 
DEEDEEDAED SVVPPGSRTT GSTAPLDASL VYDAVKYTLV VDEHTQLELV SLRRCAGLGN 

       550        560        570        580        590        600 
DSEEDSSCEA SEEEAGATLL GSDQVPEDAS PDSPDLTFSK KFLNVFVNST SRSSSTESFG 

       610        620        630        640        650        660 
LFSCVVNGEE REQTHRAVFR FIPRHPDELE LDVDDPVLVE AEEDDFWFRG FNMRTGERGV 

       670        680        690        700        710        720 
FPAFYAHAVP GPAKDLLGSK RSPCWVDRFD VQFLGSVEVP CHQGNGILCA AMQKIATARK 

       730        740        750        760        770        780 
LTVHLRPPAS CDLEISLRGV KLSLSGGGPE FQRCSHFFQM KNISFCGCHP RNSCYFGFIT 

       790        800        810        820        830 
KHPLLSRFAC HVFVSQESMR PVARSVGRAF LEYYQEHLAF ACPTEDIYLE 

Q9ERE9 in FASTA format

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