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UniProtKB/Swiss-Prot entry Q9EPC2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FGF23_MOUSE
Primary accession number Q9EPC2
Secondary accession numbers None
Integrated into Swiss-Prot on April 27, 2001
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 60)
Name and origin of the protein
Protein name Fibroblast growth factor 23 [Precursor]
Synonym FGF-23
Gene name
Name: Fgf23
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/bbrc.2000.3696; PubMed=11032749 [NCBI, ExPASy, EBI, Israel, Japan]
Yamashita T., Yoshioka M., Itoh N.;
"Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain.";
Biochem. Biophys. Res. Commun. 277:494-498(2000).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/c;
TISSUE=Embryo;
DOI=10.1038/81664; PubMed=11062477 [NCBI, ExPASy, EBI, Israel, Japan]
White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M.;
"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.";
Nat. Genet. 26:345-348(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB037889; BAB13478.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF263536; AAG09916.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00109761; -.
PIR JC7513; JC7513.
RefSeq NP_073148.1; -.
XP_001480965.1; -.
UniGene Mm.347933
3D structure databases
HSSP P03968; 1BAR. [HSSP ENTRY / PDB]
SMR Q9EPC2; 29-169.
ModBase Q9EPC2.
Organism-specific databases
MGI MGI:1891427; Fgf23.
Gene expression databases
ArrayExpress Q9EPC2; -.
Bgee Q9EPC2; -.
CleanEx MM_FGF23; -.
GermOnline ENSMUSG00000000182; Mus musculus.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005104; Molecular function: fibroblast growth factor receptor binding (traceable author statement from MGI).
GO:0008083; Molecular function: growth factor activity (traceable author statement from MGI).
GO:0030643; Biological process: cellular phosphate ion homeostasis (inferred from mutant phenotype from MGI).
GO:0030500; Biological process: regulation of bone mineralization (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR002348; IL1_HBGF.
Graphical view of domain structure.
PANTHER PTHR11486; IL1_HBGF; 1.
Pfam PF00167; FGF; 1.
Pfam graphical view of domain structure.
ProDom PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00442; FGF; 1.
SMART graphical view of domain structure.
PROSITE PS00247; HBGF_FGF; 1.
Genome annotation databases
Ensembl ENSMUSG00000000182; Mus musculus. [Contig view]
GeneID 100048681; -.
64654; -.
KEGG mmu:100048681; -.
mmu:64654; -.
Phylogenomic databases
HOGENOM Q9EPC2; -.
HOVERGEN Q9EPC2; -.
OMA Q9EPC2; ASDPLGV.
Other
NextBio 462088; -.
SOURCE Fgf23; Mus musculus.
ProtoNet Q9EPC2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Disulfide bond; Growth factor; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
SIGNAL   1    24  24     Potential. 
CHAIN   25   251  227     Fibroblast growth factor 23. PRO_0000008999
DISULFID   95   113        By similarity. 
Sequence information
Length: 251 AA [This is the length of the unprocessed precursor] Molecular weight: 27758 Da [This is the MW of the unprocessed precursor] CRC64: 110C1F2C735DC360 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLGTCLRLLV GVLCTVCSLG TARAYPDTSP LLGSNWGSLT HLYTATARTS YHLQIHRDGH 

        70         80         90        100        110        120 
VDGTPHQTIY SALMITSEDA GSVVITGAMT RRFLCMDLHG NIFGSLHFSP ENCKFRQWTL 

       130        140        150        160        170        180 
ENGYDVYLSQ KHHYLVSLGR AKRIFQPGTN PPPFSQFLAR RNEVPLLHFY TVRPRRHTRS 

       190        200        210        220        230        240 
AEDPPERDPL NVLKPRPRAT PVPVSCSREL PSAEEGGPAA SDPLGVLRRG RGDARGGAGG 

       250 
ADRCRPFPRF V
Q9EPC2 in FASTA format

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