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UniProtKB/Swiss-Prot entry Q9DCD6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GBRAP_MOUSE
Primary accession number Q9DCD6
Secondary accession number Q9QUI7
Integrated into Swiss-Prot on March 1, 2004
Sequence was last modified on March 1, 2004 (Sequence version 2)
Annotations were last modified on    September 23, 2008 (Entry version 46)
Name and origin of the protein
Protein name Gamma-aminobutyric acid receptor-associated protein
Synonym GABA(A) receptor-associated protein
Gene name
Name: Gabarap
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND INTERACTION WITH BETA-TUBULIN.
PubMed=10899939 [NCBI, ExPASy, EBI, Israel, Japan]
Wang H., Olsen R.W.;
"Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction.";
J. Neurochem. 75:644-655(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Embryo, and Kidney;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Liver, and Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH GPHN.
DOI=10.1073/pnas.97.15.8594; PubMed=10900017 [NCBI, ExPASy, EBI, Israel, Japan]
Kneussel M., Haverkamp S., Fuhrmann J.C., Wang H., Waessle H., Olsen R.W., Betz H.;
"The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse.";
Proc. Natl. Acad. Sci. U.S.A. 97:8594-8599(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF161587; AAD47642.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK002879; BAB22426.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK011731; BAB27806.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC002126; AAH02126.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC024621; AAH24621.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030350; AAH30350.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_062723.1; -.
UniGene Mm.272460
3D structure databases
SMR Q9DCD6; 1-117.
ModBase Q9DCD6.
Organism-specific databases
MGI MGI:1861742; Gabarap.
Gene expression databases
ArrayExpress Q9DCD6; -.
GermOnline ENSMUSG00000018567; Mus musculus.
Ontologies
GO
GO:0015629; Cellular component: actin cytoskeleton (inferred from direct assay from MGI).
GO:0005794; Cellular component: Golgi apparatus (inferred from direct assay from MGI).
GO:0005764; Cellular component: lysosome (inferred from direct assay from MGI).
GO:0005875; Cellular component: microtubule associated complex (inferred from direct assay from MGI).
GO:0005886; Cellular component: plasma membrane (inferred from direct assay from MGI).
GO:0005790; Cellular component: smooth endoplasmic reticulum (inferred from direct assay from MGI).
GO:0008017; Molecular function: microtubule binding (inferred from direct assay from MGI).
GO:0000226; Biological process: microtubule cytoskeleton organization and biogenesis (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR004241; MAP1_LC3.
Graphical view of domain structure.
PANTHER PTHR10969; MAP1_LC3; 1.
Pfam PF02991; MAP1_LC3; 1.
Pfam graphical view of domain structure.
BLOCKS Q9DCD6.
Genome annotation databases
Ensembl ENSMUSG00000018567; Mus musculus. [Contig view]
GeneID 56486; -.
KEGG mmu:56486; -.
Phylogenomic databases
HOGENOM Q9DCD6; -.
HOVERGEN Q9DCD6; -.
Other
SOURCE Gabarap; Mus musculus.
ProtoNet Q9DCD6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Cytoskeleton; Golgi apparatus; Membrane; Microtubule; Protein transport; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   117  117     Gamma-aminobutyric acid receptor-associated protein. PRO_0000212364
REGION   1    22  22     Interaction with beta-tubulin. 
REGION   36   117  82     Interaction with GPHN. 
REGION   36    68  33     Interaction with GABRG2 (Potential). 
CONFLICT   12    12        E -> D (in Ref. 2; BAB22426). 
Sequence information
Length: 117 AA [This is the length of the unprocessed precursor] Molecular weight: 13918 Da [This is the MW of the unprocessed precursor] CRC64: BC0B84B8A51C1E32 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 

        70         80         90        100        110 
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL 

Q9DCD6 in FASTA format

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