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UniProtKB/Swiss-Prot entry Q9CII4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH2_LACLA
Primary accession number Q9CII4
Secondary accession numbers None
Integrated into Swiss-Prot on November 16, 2001
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 54)
Name and origin of the protein
Protein name L-lactate dehydrogenase 2
Synonyms L-LDH 2
EC 1.1.1.27
Gene name
Name: ldhB
OrderedLocusNames: LL0376
ORFNames: L0018
From
Lactococcus lactis subsp. lactis (Streptococcus lactis) [TaxID: 1360] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=IL1403;
DOI=10.1101/gr.GR-1697R; PubMed=11337471 [NCBI, ExPASy, EBI, Israel, Japan]
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.;
"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403.";
Genome Res. 11:731-753(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE006274; AAK04474.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H86671; H86671.
RefSeq NP_266532.1; -.
3D structure databases
HSSP P00344; 1LDB. [HSSP ENTRY / PDB]
ModBase Q9CII4.
Enzyme and pathway databases
BioCyc LLAC272623:L0018-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q9CII4.
Genome annotation databases
GeneID 1113987; -.
GenomeReviews AE005176_GR; LL0376.
KEGG lla:L0018; -.
NMPDR fig|272623.1.peg.384; -.
Phylogenomic databases
HOGENOM Q9CII4; -.
Genome annotation databases
CMR Q9CII4; LL0376.
Other
ProtoNet Q9CII4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   314  314     L-lactate dehydrogenase 2. PRO_0000168352
NP_BIND   14    42  29     NAD (By similarity). 
ACT_SITE   178   178        Proton acceptor (By similarity). 
BINDING   91    91        Substrate (By similarity). 
BINDING   123   123        NAD or substrate (By similarity). 
BINDING   154   154        Substrate (By similarity). 
BINDING   232   232        Substrate (By similarity). 
MOD_RES   223   223        Phosphotyrosine (By similarity). 
Sequence information
Length: 314 AA [This is the length of the unprocessed precursor] Molecular weight: 34311 Da [This is the MW of the unprocessed precursor] CRC64: 57289F439CF01DDA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKITSRKVVV IGTGFVGTSI AYSMINQGLV NELVLIDVNQ DKAEGEALDL LDGVSWGQEN 

        70         80         90        100        110        120 
VIVRAGDYKD CKNADIVVVT AGVNQKPGQS RLDLVNTNAK IMRSIVTQVM DSGFDGIFVI 

       130        140        150        160        170        180 
ASNPVDILTY VAWETSGLDQ SRIVGTGTTL DTTRFRKELA TKLEIDPRSV HGYIIGEHGD 

       190        200        210        220        230        240 
SEVAVWSHTT VGGKPILEFI VKNKKIGVED LSNLSNKVKN AAYEIIDKKQ ATYYGIGMST 

       250        260        270        280        290        300 
ARIVKAILNN EQAILPVSAY LRGEYGQEGV FTGVPSIVNQ NGVREIIELN IDAYEKKQFE 

       310 
KSVSQLKEVI ESIK
Q9CII4 in FASTA format

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