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UniProtKB/Swiss-Prot entry Q9BYZ2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH6B_HUMAN
Primary accession number Q9BYZ2
Secondary accession numbers Q6DUY4 Q96LI2
Integrated into Swiss-Prot on November 16, 2001
Sequence was last modified on October 17, 2006 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 63)
Name and origin of the protein
Protein name L-lactate dehydrogenase A-like 6B
Synonym EC 1.1.1.27
Gene name
Name: LDHAL6B
Synonyms: LDHAL6, LDHL
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
Sha J.H., Li J.M., Zhou Z.M.;
"A novel intronless human testis lactate dehydrogenase gene from adult testis.";
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Tang W.W.;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS MET-14; LEU-30 AND THR-326.
TISSUE=Testis;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS MET-14; LEU-30 AND THR-326.
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY009108; AAG49399.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY642121; AAT65080.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK058192; BAB71710.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC022034; AAH22034.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_149972.1; -.
UniGene Hs.307052
3D structure databases
HSSP P00338; 1I10. [HSSP ENTRY / PDB]
SMR Q9BYZ2; 51-381.
ModBase Q9BYZ2.
Protein-protein interaction databases
IntAct Q9BYZ2; -.
PTM databases
PhosphoSite Q9BYZ2; -.
Organism-specific databases
H-InvDB HIX0012290; -.
HGNC HGNC:21481; LDHAL6B.
GenAtlas LDHAL6B.
PharmGKB PA134943157; -.
GeneCards Q9BYZ2.
Gene expression databases
ArrayExpress Q9BYZ2; -.
CleanEx HS_LDHAL6B; -.
GermOnline ENSG00000171989; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q9BYZ2.
Proteomic databases
PeptideAtlas Q9BYZ2; -.
Genome annotation databases
Ensembl ENSG00000171989; Homo sapiens. [Contig view]
GeneID 92483; -.
KEGG hsa:92483; -.
NMPDR fig|9606.3.peg.10773; -.
Phylogenomic databases
HOGENOM Q9BYZ2; -.
HOVERGEN Q9BYZ2; -.
Other
DrugBank DB00157; NADH.
LinkHub Q9BYZ2; -.
ProtoNet Q9BYZ2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycolysis; NAD; Oxidoreductase; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   381  381     L-lactate dehydrogenase A-like 6B. PRO_0000168458
NP_BIND   101   106  6     NAD (By similarity). 
ACT_SITE   242   242        Proton acceptor (By similarity). 
BINDING   148   148        NAD (By similarity). 
BINDING   155   155        Substrate (By similarity). 
BINDING   187   187        NAD or substrate (By similarity). 
BINDING   218   218        Substrate (By similarity). 
BINDING   297   297        Substrate (By similarity). 
VARIANT   14    14  1     V -> M (in dbSNP:rs3809530 [NCBI]). VAR_027936 
VARIANT   30    30  1     P -> L (in dbSNP:rs3809529 [NCBI]). VAR_027937 
VARIANT   326   326  1     I -> T (in dbSNP:rs3825937 [NCBI]). VAR_027938 [3D]
Sequence information
Length: 381 AA [This is the length of the unprocessed precursor] Molecular weight: 41943 Da [This is the MW of the unprocessed precursor] CRC64: F2B2D27E3ADE8A1D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSWTVPVVRA SQRVSSVGAN FLCLGMALCP RQATRIPLNG TWLFTPVSKM ATVKSELIER 

        70         80         90        100        110        120 
FTSEKPVHHS KVSIIGTGSV GMACAISILL KGLSDELALV DLDEDKLKGE TMDLQHGSPF 

       130        140        150        160        170        180 
TKMPNIVCSK DYFVTANSNL VIITAGARQE KGETRLNLVQ RNVAIFKLMI SSIVQYSPHC 

       190        200        210        220        230        240 
KLIIVSNPVD ILTYVAWKLS AFPKNRIIGS GCNLDTARFR FLIGQKLGIH SESCHGWILG 

       250        260        270        280        290        300 
EHGDSSVPVW SGVNIAGVPL KDLNSDIGTD KDPEQWKNVH KEVTATAYEI IKMKGYTSWA 

       310        320        330        340        350        360 
IGLSVADLTE SILKNLRRIH PVSTIIKGLY GIDEEVFLSI PCILGENGIT NLIKIKLTPE 

       370        380 
EEAHLKKSAK TLWEIQNKLK L 

Q9BYZ2 in FASTA format

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