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UniProtKB/Swiss-Prot entry Q9BYG5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PAR6B_HUMAN
Primary accession number Q9BYG5
Secondary accession number Q9Y510
Integrated into Swiss-Prot on May 16, 2003
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 62)
Name and origin of the protein
Protein name Partitioning defective 6 homolog beta
Synonyms PAR-6 beta
PAR-6B
Gene name
Name: PARD6B
Synonyms: PAR6B
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE, AND INTERACTION WITH PRKCI; PRKCZ; RAC1 AND CDC42.
TISSUE=Neuroblastoma;
PubMed=11260256 [NCBI, ExPASy, EBI, Israel, Japan]
Noda Y., Takeya R., Ohno S., Naito S., Ito T., Sumimoto H.;
"Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.";
Genes Cells 6:107-119(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH ALS2CR19 AND PARD3.
DOI=10.1016/S0378-1119(02)00681-9; PubMed=12234671 [NCBI, ExPASy, EBI, Israel, Japan]
Gao L., Macara I.G., Joberty G.;
"Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties.";
Gene 294:99-99(2002).
[5]
INTERACTION WITH LLGL1 AND PRKCI.
DOI=10.1016/S0960-9822(03)00244-6; PubMed=12725730 [NCBI, ExPASy, EBI, Israel, Japan]
Yamanaka T., Horikoshi Y., Sugiyama Y., Ishiyama C., Suzuki A., Hirose T., Iwamatsu A., Shinohara A., Ohno S.;
"Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.";
Curr. Biol. 13:734-743(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB044555; BAB40756.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031680; CAB44747.3; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC060847; AAH60847.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_115910.1; -.
UniGene Hs.589848
3D structure databases
HSSP Q9JK83; 1NF3. [HSSP ENTRY / PDB]
SMR Q9BYG5; 131-253.
ModBase Q9BYG5.
Protein-protein interaction databases
IntAct Q9BYG5; -.
Organism-specific databases
H-InvDB HIX0040491; -.
HGNC HGNC:16245; PARD6B.
GenAtlas PARD6B.
HPA HPA013376; -.
MIM 608975; gene. [NCBI / EBI]
PharmGKB PA32938; -.
GeneCards Q9BYG5.
Gene expression databases
ArrayExpress Q9BYG5; -.
CleanEx HS_PARD6B; -.
GermOnline ENSG00000124171; Homo sapiens.
Ontologies
GO
GO:0005923; Cellular component: tight junction (inferred from direct assay from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from UniProtKB).
GO:0007409; Biological process: axonogenesis (traceable author statement from UniProtKB).
GO:0007043; Biological process: cell-cell junction assembly (traceable author statement from UniProtKB).
GO:0007163; Biological process: establishment or maintenance of cell polarity (traceable author statement from UniProtKB).
GO:0030334; Biological process: regulation of cell migration (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR000270; OPR_PB1.
IPR001478; PDZ.
Graphical view of domain structure.
Pfam PF00564; PB1; 1.
PF00595; PDZ; 1.
Pfam graphical view of domain structure.
SMART SM00666; PB1; 1.
SM00228; PDZ; 1.
SMART graphical view of domain structure.
PROSITE PS50106; PDZ; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9BYG5.
Genome annotation databases
Ensembl ENSG00000124171; Homo sapiens. [Contig view]
GeneID 84612; -.
KEGG hsa:84612; -.
Phylogenomic databases
HOGENOM Q9BYG5; -.
HOVERGEN Q9BYG5; -.
Other
LinkHub Q9BYG5; -.
SOURCE PARD6B; Homo sapiens.
ProtoNet Q9BYG5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell cycle; Cell division; Cell junction; Cell membrane; Cytoplasm; Membrane; Tight junction.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   372  372     Partitioning defective 6 homolog beta. PRO_0000112516
DOMAIN   16    96  81     OPR. 
DOMAIN   133   150  18     Pseudo-CRIB. 
DOMAIN   157   250  94     PDZ. 
REGION   126   253  128     Interaction with PARD3 and CDC42 (By similarity). 
Sequence information
Length: 372 AA [This is the length of the unprocessed precursor] Molecular weight: 41182 Da [This is the MW of the unprocessed precursor] CRC64: 79B5392D72B15BDC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNRSHRHGAG SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV HKIPNVDVLV 

        70         80         90        100        110        120 
GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQKKEEAD YSAFGTDTLI KKKNVLTNVL 

       130        140        150        160        170        180 
RPDNHRKKPH IVISMPQDFR PVSSIIDVDI LPETHRRVRL YKYGTEKPLG FYIRDGSSVR 

       190        200        210        220        230        240 
VTPHGLEKVP GIFISRLVPG GLAQSTGLLA VNDEVLEVNG IEVSGKSLDQ VTDMMIANSR 

       250        260        270        280        290        300 
NLIITVRPAN QRNNVVRNSR TSGSSGQSTD NSLLGYPQQI EPSFEPEDED SEEDDIIIED 

       310        320        330        340        350        360 
NGVPQQIPKA VPNTESLESL TQIELSFESG QNGFIPSNEV SLAAIASSSN TEFETHAPDQ 

       370 
KLLEEDGTII TL 

Q9BYG5 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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