[1]	NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TNFRSF6, AND TISSUE SPECIFICITY. TISSUE=Lung fibroblast; DOI=10.1073/pnas.96.22.12667; PubMed=10535980 [NCBI, ExPASy, EBI, Israel, Japan] Somia N.V., Schmitt M.J., Vetter D.E., Van Antwerp D., Heinemann S.F., Verma I.M.; "LFG: an anti-apoptotic gene that provides protection from fas-mediated cell death."; Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1093/dnares/6.1.63; PubMed=10231032 [NCBI, ExPASy, EBI, Israel, Japan] Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.; "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."; DNA Res. 6:63-70(1999).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Protects cells uniquely from Fas-induced apoptosis.
SUBUNIT: Interacts with TNFRSF6.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity).
TISSUE SPECIFICITY: Widely expressed. Expressed at high levels in the brain especially in the hippocampus.
SIMILARITY: Belongs to the BI1 family.
SEQUENCE CAUTION:
- Sequence=AAF06327.1; Type=Frameshift; Positions=82, 130;

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF190461; AAF06327.1; ALT_FRAME; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB023167; BAA76794.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000051; AAH00051.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00017569; -.

NP_036438.2; -.

3D structure databases

ModBase

Q9BWQ8.

PTM databases

PhosphoSite

Q9BWQ8; -.

Organism-specific databases

GC12M048546; -.

HIX0010615; -.

HGNC:17067; FAIM2.

HPA018790; -.

604306; gene. [NCBI / EBI]

PharmGKB

PA134879081; -.

HUGE

KIAA0950.

Gene expression databases

Q9BWQ8; -.

Q9BWQ8; -.

HS_FAIM2; -.

ENSG00000135472; Homo sapiens.

Ontologies

GO:0030054;	Cellular component: cell junction (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0045211;	Cellular component: postsynaptic membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005515;	Molecular function: protein binding (non-traceable author statement from HGNC).
GO:0006916;	Biological process: anti-apoptosis (non-traceable author statement from UniProtKB).
GO:0006915;	Biological process: apoptosis (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR006214; UPF0005.
Graphical view of domain structure.

PANTHER

PTHR23291; UPF0005; 1.

Pfam

PF01027; UPF0005; 1.
Pfam graphical view of domain structure.

Genome annotation databases

Ensembl

ENSG00000135472; Homo sapiens. [Contig view]

GeneID

23017; -.

KEGG

hsa:23017; -.

Phylogenomic databases

HOGENOM

Q9BWQ8; -.

HOVERGEN

Q9BWQ8; -.

OMA

Q9BWQ8; SCQGVIF.

Other

43956; -.

FAIM2; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Apoptosis; Cell junction; Cell membrane; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Synapse; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 316`	`316`	`Fas apoptotic inhibitory molecule 2.`	`PRO_0000179087`
`TRANSMEM`	`106 126`	`21`	`Potential.`
`TRANSMEM`	`138 158`	`21`	`Potential.`
`TRANSMEM`	`165 185`	`21`	`Potential.`
`TRANSMEM`	`194 214`	`21`	`Potential.`
`TRANSMEM`	`225 245`	`21`	`Potential.`
`TRANSMEM`	`250 270`	`21`	`Potential.`
`TRANSMEM`	`290 310`	`21`	`Potential.`
`COMPBIAS`	`71 75`	`5`	`Poly-Ser.`
`MOD_RES`	`38 38`		`Phosphotyrosine (By similarity).`
`CARBOHYD`	`191 191`		`N-linked (GlcNAc...) (Potential).`
`CONFLICT`	`3 3`		`Q -> R (in Ref. 1; AAF06327).`

Sequence information

Length: 316 AA [This is the length of the unprocessed precursor]

Molecular weight: 35110 Da [This is the MW of the unprocessed precursor]

CRC64: 574128C7ADCC51C0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG AFPPAPTAVP 

        70         80         90        100        110        120 
LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR VFVRKVYTIL LIQLLVTLAV 

       130        140        150        160        170        180 
VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTVFTLSMA 

       190        200        210        220        230        240 
YLTGMLSSYY NTTSVLLCLG ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI 

       250        260        270        280        290        300 
LAILLPFQYV PWLHAVYAAL GAGVFTLFLA LDTQLLMGNR RHSLSPEEYI FGALNIYLDI 

       310 
IYIFTFFLQL FGTNRE

Q9BWQ8 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools