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UniProtKB/Swiss-Prot entry Q99NA5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH3A_RAT
Primary accession number Q99NA5
Secondary accession numbers None
Integrated into Swiss-Prot on July 5, 2005
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [Precursor]
Synonyms EC 1.1.1.41
Isocitric dehydrogenase
NAD(+)-specific ICDH
Gene name
Name: Idh3a
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1006/bbrc.2001.4351; PubMed=11237704 [NCBI, ExPASy, EBI, Israel, Japan]
Shinohara Y., Daikoku T., Kajimoto K., Shima A., Yamazaki N., Terada H.;
"Expression of NAD+-dependent isocitrate dehydrogenase in brown adipose tissue.";
Biochem. Biophys. Res. Commun. 281:634-638(2001).
[2]
 PROTEIN SEQUENCE OF 67-77; 101-146; 179-188; 206-214; 327-336 AND 351-361, AND MASS SPECTROMETRY.
STRAIN=Sprague-Dawley;
TISSUE=Hippocampus, and Spinal cord;
Lubec G., Afjehi-Sadat L., Chen W.-Q.;
Submitted (APR-2007) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB047541; BAB32675.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_446090.1; -.
UniGene Rn.95104
3D structure databases
HSSP P08200; 1ISO. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase Q99NA5.
Protein-protein interaction databases
IntAct Q99NA5; -.
Organism-specific databases
RGD 70889; Idh3a.
Gene expression databases
ArrayExpress Q99NA5; -.
GermOnline ENSRNOG00000010277; Rattus norvegicus.
Family and domain databases
InterPro IPR004434; IsoCit_DHase_NAD_mit.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00175; mito_nad_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q99NA5.
Genome annotation databases
Ensembl ENSRNOG00000010277; Rattus norvegicus. [Contig view]
GeneID 114096; -.
KEGG rno:114096; -.
Phylogenomic databases
HOVERGEN Q99NA5; -.
Other
ProtoNet Q99NA5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    27  27     Mitochondrion (By similarity). 
CHAIN   28   366  339     Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial. PRO_0000014440
METAL   233   233        Magnesium or manganese (By similarity). 
METAL   257   257        Magnesium or manganese (By similarity). 
METAL   261   261        Magnesium or manganese (By similarity). 
BINDING   115   115        Substrate (By similarity). 
BINDING   125   125        Substrate (By similarity). 
BINDING   146   146        Substrate (By similarity). 
BINDING   233   233        Substrate (By similarity). 
SITE   153   153  1     Critical for catalysis (By similarity). 
SITE   200   200  1     Critical for catalysis (By similarity). 
Sequence information
Length: 366 AA [This is the length of the unprocessed precursor] Molecular weight: 39614 Da [This is the MW of the unprocessed precursor] CRC64: DE5BA27AE3CF0846 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGSAWVSKV SRLLGAFHNT KQVTRGFAGG VQTVTLIPGD GIGPEISASV MKIFDAAKAP 

        70         80         90        100        110        120 
IQWEERNVTA IQGPGGKWMI PPEAKESMDK NKMGLKGPLK TPIAAGHPSM NLLLRKTFDL 

       130        140        150        160        170        180 
YANVRPCVSI EGYKTPYTDV NIVTIRENTE GEYSGIEHVI VDGVVQSIKL ITEGASKRIA 

       190        200        210        220        230        240 
EFAFEYARNN HRSNVTAVHK ANIMRMSDGL FLQKCREVAE NCKDIKFNEM YLDTVCLNMV 

       250        260        270        280        290        300 
QDPSQFDVLV MPNLYGDILS DLCAGLIGGL GVTQSGNIGA NGVAIFESVH GTAPDIAGKD 

       310        320        330        340        350        360 
MANPTALLLS AVMMLRHMGL FDHAAKIEAA CFATIKDGKS LTKDLGGNSK CSDFTEEICR 


RVKDLD
Q99NA5 in FASTA format

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