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UniProtKB/Swiss-Prot entry Q99928

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GBRG3_HUMAN
Primary accession number Q99928
Secondary accession numbers Q9HD46 Q9NYT2
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on May 4, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 72)
Name and origin of the protein
Protein name Gamma-aminobutyric acid receptor subunit gamma-3 [Precursor]
Synonym GABA(A) receptor subunit gamma-3
Gene name
Name: GABRG3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE.
TISSUE=Fetal brain;
DOI=10.1016/0922-4106(95)90070-5; PubMed=8719414 [NCBI, ExPASy, EBI, Israel, Japan]
Hadingham K.L., Wafford K.A., Thompson S.A., Palmer K.J., Whiting P.J.;
"Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.";
Eur. J. Pharmacol. 291:301-309(1995).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Han M.K., Chen Y.-H., Nurmi E.L., Sutcliffe J.S.;
"Gene structure and organization of the GABAA receptor gamma 3 subunit (GABRG3) gene.";
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-467.
Kim S.-J., Gonen D., Yang Z.-Y., Reliford A., Dy A., Leventhal B.L., Cook E.H. Jr.;
"Genomic organization of GABAA receptor gamma 3 subunit gene (GABRG3).";
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S82769; AAB39369.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF269144; AAF99698.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF269135; AAF99698.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF269136; AAF99698.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF269137; AAF99698.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF269138; AAF99698.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF269139; AAF99698.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF269140; AAF99698.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF269141; AAF99698.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF269142; AAF99698.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF269143; AAF99698.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228458; AAF63215.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228450; AAF63215.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228451; AAF63215.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228452; AAF63215.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228453; AAF63215.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228454; AAF63215.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228455; AAF63215.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228456; AAF63215.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF228457; AAF63215.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_150092.2; -.
UniGene Hs.569475
3D structure databases
ModBase Q99928.
PTM databases
PhosphoSite Q99928; -.
Organism-specific databases
HGNC HGNC:4088; GABRG3.
GenAtlas GABRG3.
MIM 600233; gene. [NCBI / EBI]
PharmGKB PA28502; -.
GeneCards Q99928.
Gene expression databases
ArrayExpress Q99928; -.
CleanEx HS_GABRG3; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (non-traceable author statement from UniProtKB).
GO:0005230; Molecular function: extracellular ligand-gated ion channel activity (non-traceable author statement from UniProtKB).
GO:0007268; Biological process: synaptic transmission (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR006028; GABAA_rcpt.
IPR005440; GABBAg3_rcpt.
IPR005437; GABBAg_rcpt.
IPR006029; Neu_channel_TM.
IPR006202; Neur_chan_lig_bd.
IPR006201; Neur_channel.
Graphical view of domain structure.
Gene3D G3DSA:2.70.170.10; Neur_chan_lig_bd; 1.
PANTHER PTHR18945; Neur_channel; 1.
Pfam PF02931; Neur_chan_LBD; 1.
PF02932; Neur_chan_memb; 1.
Pfam graphical view of domain structure.
PRINTS PR00253; GABAARECEPTR.
PR01620; GABAARGAMMA.
PR01623; GABAARGAMMA3.
PR00252; NRIONCHANNEL.
TIGRFAMs TIGR00860; LIC; 1.
PROSITE PS00236; NEUROTR_ION_CHANNEL; 1.
BLOCKS Q99928.
Genome annotation databases
Ensembl ENSG00000182256; Homo sapiens. [Contig view]
GeneID 2567; -.
KEGG hsa:2567; -.
Phylogenomic databases
HOGENOM Q99928; -.
HOVERGEN Q99928; -.
Other
SOURCE GABRG3; Homo sapiens.
ProtoNet Q99928.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell junction; Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion transport; Ionic channel; Lipoprotein; Membrane; Palmitate; Polymorphism; Postsynaptic cell membrane; Signal; Synapse; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    17  17     Potential. 
CHAIN   18   467  450     Gamma-aminobutyric acid receptor subunit gamma-3. PRO_0000000481
TOPO_DOM   18   254  237     Extracellular (Probable). 
TRANSMEM   255   277  23     Probable. 
TRANSMEM   281   303  23     Probable. 
TRANSMEM   315   337  23     Probable. 
TOPO_DOM   338   443  106     Cytoplasmic (Probable). 
TRANSMEM   444   467  24     Probable. 
CARBOHYD   110   110        N-linked (GlcNAc...) (Potential). 
CARBOHYD   228   228        N-linked (GlcNAc...) (Potential). 
DISULFID   171   185        By similarity. 
VARIANT   352   352  1     T -> A (in dbSNP:rs2066712 [NCBI]). VAR_033957 
CONFLICT   386   386        T -> P (in Ref. 1; AAB39369). 
Sequence information
Length: 467 AA [This is the length of the unprocessed precursor] Molecular weight: 54289 Da [This is the MW of the unprocessed precursor] CRC64: 1B22D145166438D6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAPKLLLLLC LFSGLHARSR KVEEDEYEDS SSNQKWVLAP KSQDTDVTLI LNKLLREYDK 

        70         80         90        100        110        120 
KLRPDIGIKP TVIDVDIYVN SIGPVSSINM EYQIDIFFAQ TWTDSRLRFN STMKILTLNS 

       130        140        150        160        170        180 
NMVGLIWIPD TIFRNSKTAE AHWITTPNQL LRIWNDGKIL YTLRLTINAE CQLQLHNFPM 

       190        200        210        220        230        240 
DEHSCPLIFS SYGYPKEEMI YRWRKNSVEA ADQKSWRLYQ FDFMGLRNTT EIVTTSAGDY 

       250        260        270        280        290        300 
VVMTIYFELS RRMGYFTIQT YIPCILTVVL SWVSFWIKKD ATPARTALGI TTVLTMTTLS 

       310        320        330        340        350        360 
TIARKSLPRV SYVTAMDLFV TVCFLFVFAA LMEYATLNYY SSCRKPTTTK KTTSLLHPDS 

       370        380        390        400        410        420 
SRWIPERISL QAPSNYSLLD MRPPPTAMIT LNNSVYWQEF EDTCVYECLD GKDCQSFFCC 

       430        440        450        460 
YEECKSGSWR KGRIHIDILE LDSYSRVFFP TSFLLFNLVY WVGYLYL
Q99928 in FASTA format

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View entry in raw text format (no links)
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