[1]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1073/pnas.94.1.142; PubMed=8990175 [NCBI, ExPASy, EBI, Israel, Japan]
Williams R.S.,
Shohet R.V.,
Stillman B.;
"A human protein related to yeast Cdc6p.";
Proc. Natl. Acad. Sci. U.S.A. 94:142-147(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND INTERACTION WITH PCNA; ORC1L AND CYCLIN-CDK.
PubMed=9566895 [NCBI, ExPASy, EBI, Israel, Japan]
Saha P.,
Chen J.,
Thome K.C.,
Lawlis S.J.,
Hou Z.H.,
Hendricks M.,
Parvin J.D.,
Dutta A.;
"Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase.";
Mol. Cell. Biol. 18:2758-2767(1998).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-238; ASN-295; MET-299; HIS-378 AND ILE-441.
NIEHS SNPs program;
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-441.
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-166, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R.,
Zhu Z.,
Chan K.C.,
Issaq H.J.,
Dimitrov D.S.,
Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
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[6]
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INTERACTION WITH HUWE1.
DOI=10.1091/mbc.E07-02-0173; PubMed=17567951 [NCBI, ExPASy, EBI, Israel, Japan]
Hall J.R.,
Kow E.,
Nevis K.R.,
Lu C.K.,
Luce K.S.,
Zhong Q.,
Cook J.G.;
"Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage.";
Mol. Biol. Cell 18:3340-3350(2007).
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[7]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-54, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
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[8]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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- FUNCTION: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
- SUBUNIT: Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1.
- INTERACTION:
P38936:CDKN1A; NbExp=1; IntAct=EBI-374862, EBI-375077;
P42771:CDKN2A; NbExp=1; IntAct=EBI-374862, EBI-375053;
Q9H211:CDT1; NbExp=2; IntAct=EBI-374862, EBI-456953;
Q7L590:MCM10; NbExp=1; IntAct=EBI-374862, EBI-374912;
P49736:MCM2; NbExp=1; IntAct=EBI-374862, EBI-374819;
P25205:MCM3; NbExp=1; IntAct=EBI-374862, EBI-355153;
Q13415:ORC1L; NbExp=1; IntAct=EBI-374862, EBI-374847;
Q13416:ORC2L; NbExp=1; IntAct=EBI-374862, EBI-374957;
Q9UBD5:ORC3L; NbExp=1; IntAct=EBI-374862, EBI-374916;
O43913:ORC5L; NbExp=1; IntAct=EBI-374862, EBI-374928;
Q9Y5N6:ORC6L; NbExp=1; IntAct=EBI-374862, EBI-374840;
P62988:RPS27A; NbExp=1; IntAct=EBI-374862, EBI-413034;
- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells.
- SIMILARITY: Belongs to the CDC6/cdc18 family.
- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CDC6ID40014ch17q21.html";.
- WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc6/";.
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