[1]
|
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
DOI=10.1074/jbc.271.49.31607; PubMed=8940179 [NCBI, ExPASy, EBI, Israel, Japan]
Wang X.S.,
Diener K.,
Jannuzzi D.,
Trollinger D.,
Tan T.-H.,
Lichenstein H.,
Zukowski M.,
Yao Z.;
"Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.";
J. Biol. Chem. 271:31607-31611(1996).
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
DOI=10.1126/science.275.5296.90; PubMed=8974401 [NCBI, ExPASy, EBI, Israel, Japan]
Ichijo H.,
Nishida E.,
Irie K.,
ten Dijke P.,
Saitoh M.,
Moriguchi T.,
Takagi M.,
Matsumoto K.,
Miyazono K.,
Gotoh Y.;
"Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.";
Science 275:90-94(1997).
|
[3]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J.,
Palmer S.A.,
Sims S.K.,
Edwards C.A.,
Ashurst J.L.,
Wilming L.,
Jones M.C.,
Horton R.,
Hunt S.E.,
Scott C.E.,
Gilbert J.G.R.,
Clamp M.E.,
Bethel G.,
Milne S.,
Ainscough R.,
Almeida J.P.,
Ambrose K.D.,
Andrews T.D.,
Ashwell R.I.S., ![]()
Babbage A.K.,
Bagguley C.L.,
Bailey J.,
Banerjee R.,
Barker D.J.,
Barlow K.F.,
Bates K.,
Beare D.M.,
Beasley H.,
Beasley O.,
Bird C.P.,
Blakey S.E.,
Bray-Allen S.,
Brook J.,
Brown A.J.,
Brown J.Y.,
Burford D.C.,
Burrill W.,
Burton J.,
Carder C.,
Carter N.P.,
Chapman J.C.,
Clark S.Y.,
Clark G.,
Clee C.M.,
Clegg S.,
Cobley V.,
Collier R.E.,
Collins J.E.,
Colman L.K.,
Corby N.R.,
Coville G.J.,
Culley K.M.,
Dhami P.,
Davies J.,
Dunn M.,
Earthrowl M.E.,
Ellington A.E.,
Evans K.A.,
Faulkner L.,
Francis M.D.,
Frankish A.,
Frankland J.,
French L.,
Garner P.,
Garnett J.,
Ghori M.J.,
Gilby L.M.,
Gillson C.J.,
Glithero R.J.,
Grafham D.V.,
Grant M.,
Gribble S.,
Griffiths C.,
Griffiths M.N.D.,
Hall R.,
Halls K.S.,
Hammond S.,
Harley J.L.,
Hart E.A.,
Heath P.D.,
Heathcott R.,
Holmes S.J.,
Howden P.J.,
Howe K.L.,
Howell G.R.,
Huckle E.,
Humphray S.J.,
Humphries M.D.,
Hunt A.R.,
Johnson C.M.,
Joy A.A.,
Kay M.,
Keenan S.J.,
Kimberley A.M.,
King A.,
Laird G.K.,
Langford C.,
Lawlor S.,
Leongamornlert D.A.,
Leversha M.,
Lloyd C.R.,
Lloyd D.M.,
Loveland J.E.,
Lovell J.,
Martin S.,
Mashreghi-Mohammadi M.,
Maslen G.L.,
Matthews L.,
McCann O.T.,
McLaren S.J.,
McLay K.,
McMurray A.,
Moore M.J.F.,
Mullikin J.C.,
Niblett D.,
Nickerson T.,
Novik K.L.,
Oliver K.,
Overton-Larty E.K.,
Parker A.,
Patel R.,
Pearce A.V.,
Peck A.I.,
Phillimore B.J.C.T.,
Phillips S.,
Plumb R.W.,
Porter K.M.,
Ramsey Y.,
Ranby S.A.,
Rice C.M.,
Ross M.T.,
Searle S.M.,
Sehra H.K.,
Sheridan E.,
Skuce C.D.,
Smith S.,
Smith M.,
Spraggon L.,
Squares S.L.,
Steward C.A.,
Sycamore N.,
Tamlyn-Hall G.,
Tester J.,
Theaker A.J.,
Thomas D.W.,
Thorpe A.,
Tracey A.,
Tromans A.,
Tubby B.,
Wall M.,
Wallis J.M.,
West A.P.,
White S.S.,
Whitehead S.L.,
Whittaker H.,
Wild A.,
Willey D.J.,
Wilmer T.E.,
Wood J.M.,
Wray P.W.,
Wyatt J.C.,
Young L.,
Younger R.M.,
Bentley D.R.,
Coulson A.,
Durbin R.M.,
Hubbard T.,
Sulston J.E.,
Dunham I.,
Rogers J.,
Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
|
[4]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye, and Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[5]
|
INTERACTION WITH DAXX, AND MUTAGENESIS OF LYS-709.
DOI=10.1126/science.281.5384.1860; PubMed=9743501 [NCBI, ExPASy, EBI, Israel, Japan]
Chang H.Y.,
Nishitoh H.,
Yang X.,
Ichijo H.,
Baltimore D.;
"Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.";
Science 281:1860-1863(1998).
|
[6]
|
INTERACTION WITH HIV-1 NEF, AND INHIBITION BY HIV-1 NEF.
DOI=10.1038/35071111; PubMed=11298454 [NCBI, ExPASy, EBI, Israel, Japan]
Geleziunas R.,
Xu W.,
Takeda K.,
Ichijo H.,
Greene W.C.;
"HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell.";
Nature 410:834-838(2001).
|
[7]
|
FUNCTION, HOMODIMERIZATION, ENZYME REGULATION, AND PHOSPHORYLATION AT THR-838.
DOI=10.1002/jcp.10080; PubMed=11920685 [NCBI, ExPASy, EBI, Israel, Japan]
Tobiume K.,
Saitoh M.,
Ichijo H.;
"Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer.";
J. Cell. Physiol. 191:95-104(2002).
|
[8]
|
INTERACTION WITH DAB2IP.
PubMed=12813029 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang R.,
He X.,
Liu W.,
Lu M.,
Hsieh J.-T.,
Min W.;
"AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3.";
J. Clin. Invest. 111:1933-1943(2003).
|
[9]
|
INTERACTION WITH DAB2IP.
DOI=10.1074/jbc.M407617200; PubMed=15310755 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang H.,
Zhang R.,
Luo Y.,
D'Alessio A.,
Pober J.S.,
Min W.;
"AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.";
J. Biol. Chem. 279:44955-44965(2004).
|
[10]
|
ENZYME REGULATION, PHOSPHORYLATION AT SER-966 AND SER-1033, MUTAGENESIS OF SER-966 AND SER-1033, AND INTERACTION WITH YWHAG.
DOI=10.1038/sj.onc.1207668; PubMed=15094778 [NCBI, ExPASy, EBI, Israel, Japan]
Fujii K.,
Goldman E.H.,
Park H.R.,
Zhang L.,
Chen J.,
Fu H.;
"Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.";
Oncogene 23:5099-5104(2004).
|
[11]
|
INTERACTION WITH PPM1L.
DOI=10.1042/BJ20070231; PubMed=17456047 [NCBI, ExPASy, EBI, Israel, Japan]
Saito J.,
Toriumi S.,
Awano K.,
Ichijo H.,
Sasaki K.,
Kobayashi T.,
Tamura S.;
"Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.";
Biochem. J. 405:591-596(2007).
|
[12]
|
ENZYME REGULATION, INTERACTION WITH MAP3K5, PHOSPHORYLATION AT THR-838, AND MUTAGENESIS OF LYS-709.
DOI=10.1074/jbc.M607177200; PubMed=17210579 [NCBI, ExPASy, EBI, Israel, Japan]
Takeda K.,
Shimozono R.,
Noguchi T.,
Umeda T.,
Morimoto Y.,
Naguro I.,
Tobiume K.,
Saitoh M.,
Matsuzawa A.,
Ichijo H.;
"Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.";
J. Biol. Chem. 282:7522-7531(2007).
|
[13]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1029 AND SER-1033, AND MASS SPECTROMETRY.
TISSUE=Platelet;
DOI=10.1021/pr0704130; PubMed=18088087 [NCBI, ExPASy, EBI, Israel, Japan]
Zahedi R.P.,
Lewandrowski U.,
Wiesner J.,
Wortelkamp S.,
Moebius J.,
Schuetz C.,
Walter U.,
Gambaryan S.,
Sickmann A.;
"Phosphoproteome of resting human platelets.";
J. Proteome Res. 7:526-534(2008).
|
[14]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1029 AND SER-1033, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
|
[15]
|
VARIANTS [LARGE SCALE ANALYSIS] ARG-1006; THR-1214; VAL-1250; ILE-1314 AND ASN-1315.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
|
|
ExPASy Home page
SIB Switzerland
