ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q99615


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name DNJC7_HUMAN
Primary accession number Q99615
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on April 13, 2004 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 85)
Name and origin of the protein
Protein name DnaJ homolog subfamily C member 7
Synonyms Tetratricopeptide repeat protein 2
TPR repeat protein 2
Gene name
Name: DNAJC7
Synonyms: TPR2, TTC2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] OF 3-494.
DOI=10.1089/dna.1996.15.727; PubMed=8836031 [NCBI, ExPASy, EBI, Israel, Japan]
Murthy A.E., Bernards A., Church D., Wasmuth J., Gusella J.F.;
"Identification and characterization of two novel tetratricopeptide repeat-containing genes.";
DNA Cell Biol. 15:727-735(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 2-26; 69-77; 80-90; 138-156; 192-238; 274-291 AND 430-442, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, AND MASS SPECTROMETRY.
TISSUE=Embryonic kidney;
Bienvenut W.V., Waridel P., Quadroni M.;
Submitted (MAR-2009) to UniProtKB.
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-50, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
[5]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U46571; AAB36872.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011837; AAH11837.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033772; AAH33772.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00329629; -.
UniGene Hs.500156
3D structure databases
HSSP P08622; 1BQZ. [HSSP ENTRY / PDB]
ModBase Q99615.
Protein-protein interaction databases
IntAct Q99615; 3.
PTM databases
PhosphoSite Q99615; -.
Organism-specific databases
GeneCards GC17M037382; -.
H-InvDB HIX0013829; -.
HGNC HGNC:12392; DNAJC7.
GenAtlas DNAJC7.
MIM 601964; gene. [NCBI / EBI]
PharmGKB PA27424; -.
Gene expression databases
ArrayExpress Q99615; -.
Bgee Q99615; -.
CleanEx HS_DNAJC7; -.
GermOnline ENSG00000168259; Homo sapiens.
Ontologies
GO
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
GO:0006457; Biological process: protein folding (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
IPR015609; Hsp40/DnaJ_Rel.
IPR001440; TPR-1.
IPR011990; TPR-like_helical.
IPR013026; TPR_region.
IPR019734; TPR_repeat.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.10; TPR-like_helical; 2.
PANTHER PTHR11821; Hsp40/DnaJ_Rel; 1.
Pfam PF00226; DnaJ; 1.
PF00515; TPR_1; 7.
Pfam graphical view of domain structure.
SMART SM00271; DnaJ; 1.
SM00028; TPR; 7.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; FALSE_NEG.
PS50076; DNAJ_2; 1.
PS50005; TPR; 8.
PS50293; TPR_REGION; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PeptideAtlas Q99615; -.
PRIDE Q99615; -.
Genome annotation databases
Ensembl ENSG00000168259; Homo sapiens. [Contig view]
KEGG hsa:7266; -.
Phylogenomic databases
HOGENOM Q99615; -.
HOVERGEN Q99615; -.
OMA Q99615; SFKEQGN.
Other
NextBio 28407; -.
PMAP-CutDB Q99615; -.
SOURCE DNAJC7; Homo sapiens.
ProtoNet Q99615.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Chaperone; Direct protein sequencing; Phosphoprotein; Repeat; TPR repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   494  493     DnaJ homolog subfamily C member 7. PRO_0000071058
REPEAT   28    61  34     TPR 1. 
REPEAT   62    95  34     TPR 2. 
REPEAT   96   129  34     TPR 3. 
REPEAT   142   175  34     TPR 4. 
REPEAT   177   209  33     TPR 5. 
REPEAT   210   243  34     TPR 6. 
REPEAT   256   289  34     TPR 7. 
REPEAT   294   327  34     TPR 8. 
REPEAT   328   361  34     TPR 9. 
DOMAIN   381   451  71     J. 
MOD_RES   2     2        N-acetylalanine. 
MOD_RES   50    50        Phosphotyrosine. 
Sequence information
Length: 494 AA [This is the length of the unprocessed precursor] Molecular weight: 56441 Da [This is the MW of the unprocessed precursor] CRC64: 81C60CF71BFE951D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAAAECDVV MAATEPELLD DQEAKREAET FKEQGNAYYA KKDYNEAYNY YTKAIDMCPK 

        70         80         90        100        110        120 
NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL REGKCHLSLG NAMAACRSFQ 

       130        140        150        160        170        180 
RALELDHKNA QAQQEFKNAN AVMEYEKIAE TDFEKRDFRK VVFCMDRALE FAPACHRFKI 

       190        200        210        220        230        240 
LKAECLAMLG RYPEAQSVAS DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA 

       250        260        270        280        290        300 
PDHEKACIAC RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR 

       310        320        330        340        350        360 
GTVNSKLRKL DDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQYEEAVRD YEKVYQTEKT 

       370        380        390        400        410        420 
KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA YRKRALMHHP DRHSGASAEV 

       430        440        450        460        470        480 
QKEEEKKFKE VGEAFTILSD PKKKTRYDSG QDLDEEGMNM GDFDPNNIFK AFFGGPGGFS 

       490 
FEASGPGNFF FQFG 

Q99615 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!