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UniProtKB/Swiss-Prot entry Q99460


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PSMD1_HUMAN
Primary accession number Q99460
Secondary accession numbers Q24JU0 Q53TI2 Q6GMU5 Q6P2P4 Q6PJM7 Q6PKG9 Q86VU1 Q8IV79
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on August 31, 2004 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 76)
Name and origin of the protein
Protein name 26S proteasome non-ATPase regulatory subunit 1
Synonyms 26S proteasome regulatory subunit RPN2
26S proteasome regulatory subunit S1
26S proteasome subunit p112
Gene name
Name: PSMD1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=8816993 [NCBI, ExPASy, EBI, Israel, Japan]
Yokota K., Kagawa S., Shimizu Y., Akioka H., Tsurumi C., Noda C., Fujimuro M., Yokosawa H., Fujiwara T., Takahashi E., Ohba M., Yamasaki M., DeMartino G.N., Slaughter C.A., Toh-e A., Tanaka K.;
"cDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p.";
Mol. Biol. Cell 7:853-870(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Cervix, Liver, Lymph, Placenta, Testis, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-273; THR-311 AND SER-315, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-49, AND MASS SPECTROMETRY.
TISSUE=Hepatocyte;
DOI=10.1002/pmic.200401217; PubMed=16097034 [NCBI, ExPASy, EBI, Israel, Japan]
Gevaert K., Staes A., Van Damme J., De Groot S., Hugelier K., Demol H., Martens L., Goethals M., Vandekerckhove J.;
"Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.";
Proteomics 5:3589-3599(2005).
[6]
INTERACTION WITH ADRM1.
DOI=10.1038/sj.emboj.7601338; PubMed=16990800 [NCBI, ExPASy, EBI, Israel, Japan]
Hamazaki J., Iemura S., Natsume T., Yashiroda H., Tanaka K., Murata S.;
"A novel proteasome-interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.";
EMBO J. 25:4524-4536(2006).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-311 AND SER-315, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[8]
INTERACTION WITH ADRM1.
DOI=10.1038/ncb1460; PubMed=16906146 [NCBI, ExPASy, EBI, Israel, Japan]
Yao T., Song L., Xu W., DeMartino G.N., Florens L., Swanson S.K., Washburn M.P., Conaway R.C., Conaway J.W., Cohen R.E.;
"Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.";
Nat. Cell Biol. 8:994-1002(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-311 AND SER-315, ACETYLATION AT MET-1, AND MASS SPECTROMETRY.
DOI=10.1021/bi061994u; PubMed=17323924 [NCBI, ExPASy, EBI, Israel, Japan]
Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.;
"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.";
Biochemistry 46:3553-3565(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D44466; BAA07918.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC009407; AAX93127.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001053; AAH01053.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014013; AAH14013.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC039845; AAH39845.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC047897; AAH47897.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC064398; AAH64398.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC073833; AAH73833.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC094720; AAH94720.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC112344; AAI12345.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC114434; AAI14435.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_002798.2; -.
UniGene Hs.3887
3D structure databases
ModBase Q99460.
Protein-protein interaction databases
DIP DIP:27548N; -.
IntAct Q99460; -.
PTM databases
PhosphoSite Q99460; -.
Enzyme and pathway databases
Reactome REACT_11045; Signaling by Wnt.
REACT_152; Cell Cycle, Mitotic.
REACT_1538; Cell Cycle Checkpoints.
REACT_383; DNA Replication.
REACT_6185; HIV Infection.
REACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
REACT_9035; APC/C:Cdh1-mediated degradation of Skp2.
Organism-specific databases
H-InvDB HIX0029913; -.
HGNC HGNC:9554; PSMD1.
GenAtlas PSMD1.
PharmGKB PA33899; -.
GeneCards Q99460.
Gene expression databases
ArrayExpress Q99460; -.
CleanEx HS_PSMD1; -.
GermOnline ENSG00000173692; Homo sapiens.
Ontologies
GO
GO:0005838; Cellular component: proteasome regulatory particle (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0031145; Biological process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (inferred from experiment from Reactome).
GO:0051436; Biological process: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle (inferred from experiment from Reactome).
GO:0051437; Biological process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle (inferred from experiment from Reactome).
QuickGo view.
Family and domain databases
InterPro IPR016642; 26S_Psome_Rpn2.
IPR002015; APC_proteasome.
IPR011989; ARM-like.
Graphical view of domain structure.
Gene3D G3DSA:1.25.10.10; ARM-like; 1.
Pfam PF01851; PC_rep; 8.
Pfam graphical view of domain structure.
PIRSF PIRSF015947; 26S_Psome_Rpn2; 1.
BLOCKS Q99460.
Genome annotation databases
Ensembl ENSG00000173692; Homo sapiens. [Contig view]
GeneID 5707; -.
KEGG hsa:5707; -.
NMPDR fig|9606.3.peg.19493; -.
Phylogenomic databases
HOVERGEN Q99460; -.
Other
DrugBank DB00188; Bortezomib.
ProtoNet Q99460.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Alternative splicing; Phosphoprotein; Proteasome; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   953  953     26S proteasome non-ATPase regulatory subunit 1. PRO_0000173801
REPEAT   403   436  34     PC 1. 
REPEAT   441   474  34     PC 2. 
REPEAT   476   510  35     PC 3. 
REPEAT   511   545  35     PC 4. 
REPEAT   547   580  34     PC 5. 
REPEAT   581   616  36     PC 6. 
REPEAT   617   649  33     PC 7. 
REPEAT   651   685  35     PC 8. 
REPEAT   686   726  41     PC 9. 
REPEAT   729   761  33     PC 10. 
COMPBIAS   936   943  8     Poly-Glu. 
MOD_RES   1     1        N-acetylmethionine; partial. 
MOD_RES   49    49        Phosphotyrosine. 
MOD_RES   273   273        Phosphothreonine. 
MOD_RES   311   311        Phosphothreonine. 
MOD_RES   315   315        Phosphoserine. 
VAR_SEQ   797   827        Missing (in isoform 2). VSP_011475
CONFLICT   85    85        G -> R (in Ref. 1; BAA07918). 
CONFLICT   616   616        R -> S (in Ref. 1; BAA07918). 
Sequence information
Length: 953 AA [This is the length of the unprocessed precursor] Molecular weight: 105836 Da [This is the MW of the unprocessed precursor] CRC64: B8682146082D21FA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MITSAAGIIS LLDEDEPQLK EFALHKLNAV VNDFWAEISE SVDKIEVLYE DEGFRSRQFA 

        70         80         90        100        110        120 
ALVASKVFYH LGAFEESLNY ALGAGDLFNV NDNSEYVETI IAKCIDHYTK QCVENADLPE 

       130        140        150        160        170        180 
GEKKPIDQRL EGIVNKMFQR CLDDHKYKQA IGIALETRRL DVFEKTILES NDVPGMLAYS 

       190        200        210        220        230        240 
LKLCMSLMQN KQFRNKVLRV LVKIYMNLEK PDFINVCQCL IFLDDPQAVS DILEKLVKED 

       250        260        270        280        290        300 
NLLMAYQICF DLYESASQQF LSSVIQNLRT VGTPIASVPG STNTGTVPGS EKDSDSMETE 

       310        320        330        340        350        360 
EKTSSAFVGK TPEASPEPKD QTLKMIKILS GEMAIELHLQ FLIRNNNTDL MILKNTKDAV 

       370        380        390        400        410        420 
RNSVCHTATV IANSFMHCGT TSDQFLRDNL EWLARATNWA KFTATASLGV IHKGHEKEAL 

       430        440        450        460        470        480 
QLMATYLPKD TSPGSAYQEG GGLYALGLIH ANHGGDIIDY LLNQLKNASN DIVRHGGSLG 

       490        500        510        520        530        540 
LGLAAMGTAR QDVYDLLKTN LYQDDAVTGE AAGLALGLVM LGSKNAQAIE DMVGYAQETQ 

       550        560        570        580        590        600 
HEKILRGLAV GIALVMYGRM EEADALIESL CRDKDPILRR SGMYTVAMAY CGSGNNKAIR 

       610        620        630        640        650        660 
RLLHVAVSDV NDDVRRAAVE SLGFILFRTP EQCPSVVSLL SESYNPHVRY GAAMALGICC 

       670        680        690        700        710        720 
AGTGNKEAIN LLEPMTNDPV NYVRQGALIA SALIMIQQTE ITCPKVNQFR QLYSKVINDK 

       730        740        750        760        770        780 
HDDVMAKFGA ILAQGILDAG GHNVTISLQS RTGHTHMPSV VGVLVFTQFW FWFPLSHFLS 

       790        800        810        820        830        840 
LAYTPTCVIG LNKDLKMPKV QYKSNCKPST FAYPAPLEVP KEKEKEKVST AVLSITAKAK 

       850        860        870        880        890        900 
KKEKEKEKKE EEKMEVDEAE KKEEKEKKKE PEPNFQLLDN PARVMPAQLK VLTMPETCRY 

       910        920        930        940        950 
QPFKPLSIGG IIILKDTSED IEELVEPVAA HGPKIEEEEQ EPEPPEPFEY IDD 

Q99460 in FASTA format

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