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UniProtKB/Swiss-Prot entry Q97MD1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH1_CLOAB
Primary accession number Q97MD1
Secondary accession numbers None
Integrated into Swiss-Prot on November 16, 2001
Sequence was last modified on October 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 54)
Name and origin of the protein
Protein name L-lactate dehydrogenase 1
Synonyms L-LDH 1
EC 1.1.1.27
Gene name
Name: ldh1
Synonyms: ldh
OrderedLocusNames: CA_C0267
From
Clostridium acetobutylicum [TaxID: 1488] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
DOI=10.1128/JB.183.16.4823-4838.2001; PubMed=11466286 [NCBI, ExPASy, EBI, Israel, Japan]
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.;
"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum.";
J. Bacteriol. 183:4823-4838(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE001437; AAK78248.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E96932; E96932.
RefSeq NP_346908.1; -.
3D structure databases
HSSP P00344; 2LDB. [HSSP ENTRY / PDB]
ModBase Q97MD1.
Enzyme and pathway databases
BioCyc CACE272562:CAC0267-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q97MD1.
Genome annotation databases
GeneID 1116450; -.
GenomeReviews AE001437_GR; CA_C0267.
KEGG cac:CAC0267; -.
NMPDR fig|272562.1.peg.437; -.
Phylogenomic databases
HOGENOM Q97MD1; -.
Genome annotation databases
CMR Q97MD1; CA_C0267.
Other
ProtoNet Q97MD1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   313  313     L-lactate dehydrogenase 1. PRO_0000168333
NP_BIND   13    41  29     NAD (By similarity). 
ACT_SITE   176   176        Proton acceptor (By similarity). 
BINDING   89    89        Substrate (By similarity). 
BINDING   121   121        NAD or substrate (By similarity). 
BINDING   152   152        Substrate (By similarity). 
BINDING   231   231        Substrate (By similarity). 
MOD_RES   222   222        Phosphotyrosine (By similarity). 
Sequence information
Length: 313 AA [This is the length of the unprocessed precursor] Molecular weight: 34181 Da [This is the MW of the unprocessed precursor] CRC64: C98FD402E62F45D2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKKNTKISVI GAGFVGSSTV FALMNGGLAS EIVIVDVNKD KAEGEAMDLS HGAAFVKPVV 

        70         80         90        100        110        120 
VKSGDYKDTE GSDIVIITAG AAQKPGETRL ELINKNYNIF KSIVPEVVKY NPNAILLVVS 

       130        140        150        160        170        180 
NPVDILTYIT YKLSGFPKSR VIGSGTVLDT SRFRYMLSEH FEIDVRNIHT YIMGEHGDSE 

       190        200        210        220        230        240 
IATWSLTNIA GMDVNEYCEA SCKKCDGSLK YKIYDDVKNA AYHVIEKKGA TYYAVALAVK 

       250        260        270        280        290        300 
RIVEAILRDE NSILTVSSLL EGQYGIKDVY MGVPSIVGIN GVKDIIEVPL NDEEKNNLTD 

       310 
SAKTLKESLD SIF
Q97MD1 in FASTA format

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