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UniProtKB/Swiss-Prot entry Q97LN7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_CLOAB
Primary accession number Q97LN7
Secondary accession numbers None
Integrated into Swiss-Prot on October 10, 2002
Sequence was last modified on October 1, 2001 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 53)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: CA_C0519
From
Clostridium acetobutylicum [TaxID: 1488] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
DOI=10.1128/JB.183.16.4823-4838.2001; PubMed=11466286 [NCBI, ExPASy, EBI, Israel, Japan]
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.;
"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum.";
J. Bacteriol. 183:4823-4838(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE001437; AAK78499.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H96963; H96963.
RefSeq NP_347159.1; -.
3D structure databases
ModBase Q97LN7.
Enzyme and pathway databases
BioCyc CACE272562:CAC0519-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; FALSE_NEG.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q97LN7.
Genome annotation databases
GeneID 1116702; -.
GenomeReviews AE001437_GR; CA_C0519.
KEGG cac:CAC0519; -.
NMPDR fig|272562.1.peg.688; -.
Phylogenomic databases
HOGENOM Q97LN7; -.
Genome annotation databases
CMR Q97LN7; CA_C0519.
Other
ProtoNet Q97LN7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   424  424     Dihydroorotase. PRO_0000147231
METAL   60    60        Zinc 1 (By similarity). 
METAL   62    62        Zinc 1 (By similarity). 
METAL   141   141        Zinc 1; via carbamate group (By similarity). 
METAL   141   141        Zinc 2; via carbamate group (By similarity). 
METAL   178   178        Zinc 2 (By similarity). 
METAL   231   231        Zinc 2 (By similarity). 
METAL   304   304        Zinc 1 (By similarity). 
MOD_RES   141   141        N6-carboxylysine (By similarity). 
Sequence information
Length: 424 AA [This is the length of the unprocessed precursor] Molecular weight: 46528 Da [This is the MW of the unprocessed precursor] CRC64: 4A8D60A4726F473D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIIIKNGYVI DPLTKREGKF DILIDGENVV RISQDIGIDD DIEVIDAEDC IVSPGFIDIH 

        70         80         90        100        110        120 
SHFRDPGFTE KEDIITGARA AARGGYTTVI CMANTNPVVD NVETLRYIVD KAKTAKIEVL 

       130        140        150        160        170        180 
QVGTITKGMQ GVELVDMEAL KEAGAVGFSD DGKPIMDSRL VLEAMQKARE LDVPLSFHEE 

       190        200        210        220        230        240 
DPKLVYESGI NGGKVAEKLN MMGALEEAET VLTARDAALA VSSGAKTNIQ HISSKISLGI 

       250        260        270        280        290        300 
IKLAKEMGAN IIAEATPQHF SITEEEILNC GTNAKVNPPL RREDDRKAIV AALKDDTIQV 

       310        320        330        340        350        360 
IATDHAPHTK DEKAREFKEA PSGMIGLETA LSLAVTNLVK TGDLTYRDMI SKLTINPARF 

       370        380        390        400        410        420 
YNLDRGYIKE GHRADIVIFD PDEKYTVKEE EFQSKASNSP FIGKELFGKV KTTIYNGKIV 


YEDK
Q97LN7 in FASTA format

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