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UniProtKB/Swiss-Prot entry Q96TC7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RMD3_HUMAN
Primary accession number Q96TC7
Secondary accession numbers A9UMZ9 Q6ZWE9 Q96H23 Q96SD6 Q9H6G1 Q9NVQ6
Integrated into Swiss-Prot on May 15, 2007
Sequence was last modified on May 15, 2007 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 37)
Name and origin of the protein
Protein name Regulator of microtubule dynamics protein 3
Synonyms RMD-3
hRMD-3
Protein FAM82A2
Protein FAM82C
Protein tyrosine phosphatase-interacting protein 51
TCPTP-interacting protein 51
Cerebral protein 10
Gene name
Name: FAM82A2
Synonyms: FAM82C, PTPIP51
ORFNames: hucep-10, UNQ3122/PRO10274
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
Yoshimoto M., Yazaki M., Matsumoto K., Takayama K.;
"Molecular cloning of a novel gene expressed in human cerebral cortex.";
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Teratocarcinoma;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 78-470.
Porsche A., Hofer W.H.;
"A protein interacting with T-cell tyrosine phosphatase.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
[6]
IDENTIFICATION, INTERACTION WITH MICROTUBULES, AND SUBCELLULAR LOCATION.
DOI=10.1083/jcb.200705108; PubMed=18070910 [NCBI, ExPASy, EBI, Israel, Japan]
Oishi K., Okano H., Sawa H.;
"RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans.";
J. Cell Biol. 179:1149-1162(2007).
[7]
TISSUE SPECIFICITY, AND INTERACTION WITH PTPN2.
DOI=10.1007/s00418-004-0732-7; PubMed=15609043 [NCBI, ExPASy, EBI, Israel, Japan]
Stenzinger A., Kajosch T., Tag C., Porsche A., Welte I., Hofer H.W., Steger K., Wimmer M.;
"The novel protein PTPIP51 exhibits tissue- and cell-specific expression.";
Histochem. Cell Biol. 123:19-28(2005).
[8]
FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1007/s10495-006-8882-9; PubMed=16820967 [NCBI, ExPASy, EBI, Israel, Japan]
Lv B.F., Yu C.F., Chen Y.Y., Lu Y., Guo J.H., Song Q.S., Ma D.L., Shi T.P., Wang L.;
"Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondria protein with an N-terminal mitochondrial targeting sequence and induces apoptosis.";
Apoptosis 11:1489-1501(2006).
[9]
INDUCTION, AND SUBCELLULAR LOCATION.
DOI=10.1159/000098949; PubMed=17361080 [NCBI, ExPASy, EBI, Israel, Japan]
Stenzinger A., Schreiner D., Pfeiffer T., Tag C., Hofer H.W., Wimmer M.;
"Epidermal growth factor-, transforming growth factor-beta-, retinoic acid-and 1,25-dihydroxyvitamin D(3)-regulated expression of the novel protein PTPIP51 in keratinocytes.";
Cells Tissues Organs 184:76-87(2006).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
Comments
  • FUNCTION: May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
  • SUBUNIT: Interacts with PTPN2. Interacts with microtubules.
  • INTERACTION:
    P31946:YWHAB; NbExp=1; IntAct=EBI-1056589, EBI-359815;
    P61981:YWHAG; NbExp=1; IntAct=EBI-1056589, EBI-359832;
  • SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Nucleus. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.
  • ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.
    Name1
    Isoform IDQ96TC7-1
    This is the isoform sequence displayed in this entry.
    Name2
    Isoform IDQ96TC7-2
    Note: No experimental confirmation available.
    Features which should be applied to build the isoform sequence: VSP_025531.
  • TISSUE SPECIFICITY: Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.
  • INDUCTION: By EGF, TGF-beta, retinoic acid-and 1,25-Dihydroxyvitamin D(3).
  • DOMAIN: The transmembrane region is required for mitochondrial localization.
  • SIMILARITY: Belongs to the FAM82/RMD family.
  • SEQUENCE CAUTION:
    • Sequence=BAB15298.1; Type=Erroneous termination; Positions=453; Note=Translated as Glu
    • Sequence=BAC85554.1; Type=Frameshift; Positions=383;
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB000782; BAB46923.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358793; AAQ89153.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK001441; BAA91693.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK025963; BAB15298.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK123192; BAC85554.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC008970; AAH08970.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC063844; AAH63844.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ242719; CAC39480.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BR000691; FAA00416.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_060615.1; -.
UniGene Hs.511067
3D structure databases
ModBase Q96TC7.
Protein-protein interaction databases
IntAct Q96TC7; -.
PTM databases
PhosphoSite Q96TC7; -.
Organism-specific databases
HGNC HGNC:25550; FAM82A2.
GenAtlas FAM82A2.
HPA HPA009975; -.
MIM 611873; gene. [NCBI / EBI]
PharmGKB PA142671850; -.
GeneCards Q96TC7.
Gene expression databases
ArrayExpress Q96TC7; -.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR011990; TPR-like_helical.
Graphical view of domain structure.
Gene3D G3DSA:1.25.40.10; TPR-like_helical; 1.
BLOCKS Q96TC7.
Proteomic databases
PeptideAtlas Q96TC7; -.
Genome annotation databases
Ensembl ENSG00000137824; Homo sapiens. [Contig view]
GeneID 55177; -.
KEGG hsa:55177; -.
Phylogenomic databases
HOGENOM Q96TC7; -.
HOVERGEN Q96TC7; -.
Other
SOURCE FAM82A2; Homo sapiens.
ProtoNet Q96TC7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Apoptosis; Coiled coil; Cytoplasm; Differentiation; Membrane; Microtubule; Mitochondrion; Nucleus; Phosphoprotein; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   470  470     Regulator of microtubule dynamics protein 3. PRO_0000287510
TRANSMEM   13    35  23     Potential. 
COILED   92   124  33     Potential. 
MOD_RES   46    46        Phosphoserine. 
MOD_RES   189   189        Phosphoserine (By similarity). 
MOD_RES   212   212        Phosphoserine (By similarity). 
VAR_SEQ   1   129        Missing (in isoform 2). VSP_025531
CONFLICT   416   416        F -> V (in Ref. 1; BAB46923). 
CONFLICT   469   469        R -> Q (in Ref. 3; BAC85554). 
Sequence information
Length: 470 AA [This is the length of the unprocessed precursor] Molecular weight: 52118 Da [This is the MW of the unprocessed precursor] CRC64: 1C8D1022E6CF7B6A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSRLGALGGA RAGLGLLLGT AAGLGFLCLL YSQRWKRTQR HGRSQSLPNS LDYTQTSDPG 

        70         80         90        100        110        120 
RHVMLLRAVP GGAGDASVLP SLPREGQEKV LDRLDFVLTS LVALRREVEE LRSSLRGLAG 

       130        140        150        160        170        180 
EIVGEVRCHM EENQRVARRR RFPFVRERSD STGSSSVYFT ASSGATFTDA ESEGGYTTAN 

       190        200        210        220        230        240 
AESDNERDSD KESEDGEDEV SCETVKMGRK DSLDLEEEAA SGASSALEAG GSSGLEDVLP 

       250        260        270        280        290        300 
LLQQADELHR GDEQGKREGF QLLLNNKLVY GSRQDFLWRL ARAYSDMCEL TEEVSEKKSY 

       310        320        330        340        350        360 
ALDGKEEAEA ALEKGDESAD CHLWYAVLCG QLAEHESIQR RIQSGFSFKE HVDKAIALQP 

       370        380        390        400        410        420 
ENPMAHFLLG RWCYQVSHLS WLEKKTATAL LESPLSATVE DALQSFLKAE ELQPGFSKAG 

       430        440        450        460        470 
RVYISKCYRE LGKNSEARWW MKLALELPDV TKEDLAIQKD LEELEVILRD 

Q96TC7 in FASTA format

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View entry in raw text format (no links)
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