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UniProtKB/Swiss-Prot entry Q96T25


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ZIC5_HUMAN
Primary accession number Q96T25
Secondary accession number Q5VYB0
Integrated into Swiss-Prot on April 23, 2003
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 55)
Name and origin of the protein
Protein name Zinc finger protein ZIC 5
Synonym Zinc finger protein of the cerebellum 5
Gene name
Name: ZIC5
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Gou D.M., Li W.X., Gao L., Sun Y.;
"A novel human zinc finger gene, hZic5.";
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02379; PubMed=15057823 [NCBI, ExPASy, EBI, Israel, Japan]
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
"The DNA sequence and analysis of human chromosome 13.";
Nature 428:522-528(2004).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-554 AND SER-576, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF378304; AAK55418.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL355338; CAH70366.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00872778; -.
RefSeq NP_149123.2; -.
UniGene Hs.508570
3D structure databases
HSSP P08047; 1SP2. [HSSP ENTRY / PDB]
ModBase Q96T25.
PTM databases
PhosphoSite Q96T25; -.
Organism-specific databases
GeneCards GC13M099415; -.
HGNC HGNC:20322; ZIC5.
GenAtlas ZIC5.
PharmGKB PA134941698; -.
Gene expression databases
ArrayExpress Q96T25; -.
Bgee Q96T25; -.
CleanEx HS_ZIC5; -.
GermOnline ENSG00000139800; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030154; Biological process: cell differentiation (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
IPR013087; Znf_C2H2/integrase_DNA-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
Pfam PF00096; zf-C2H2; 4.
Pfam graphical view of domain structure.
ProDom PD000003; Znf_C2H2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00355; ZnF_C2H2; 5.
SMART graphical view of domain structure.
PROSITE PS00028; ZINC_FINGER_C2H2_1; 3.
PS50157; ZINC_FINGER_C2H2_2; 4.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q96T25; -.
Genome annotation databases
Ensembl ENSG00000139800; Homo sapiens. [Contig view]
GeneID 85416; -.
KEGG hsa:85416; -.
Phylogenomic databases
HOGENOM Q96T25; -.
HOVERGEN Q96T25; -.
Other
NextBio 75994; -.
ProtoNet Q96T25.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Developmental protein; Differentiation; DNA-binding; Metal-binding; Neurogenesis; Nucleus; Phosphoprotein; Repeat; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   639  639     Zinc finger protein ZIC 5. PRO_0000047255
ZN_FING   434   461  28     C2H2-type 1; atypical. 
ZN_FING   467   491  25     C2H2-type 2. 
ZN_FING   497   521  25     C2H2-type 3. 
ZN_FING   527   551  25     C2H2-type 4. 
COMPBIAS   82   400  319     Pro-rich. 
COMPBIAS   262   321  60     Ala-rich. 
MOD_RES   554   554        Phosphoserine. 
MOD_RES   576   576        Phosphoserine. 
Sequence information
Length: 639 AA [This is the length of the unprocessed precursor] Molecular weight: 65849 Da [This is the MW of the unprocessed precursor] CRC64: FB1E966ED28D38BF [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEPPLSKRNP PALRLADLAT AQVQPLQNMT GFPALAGPPA HSQLRAAVAH LRLRDLGADP 

        70         80         90        100        110        120 
GVATTPLGPE HMAQASTLGL SPPSQAFPAH PEAPAAAARA AALVAHPGAG SYPCGGGSSG 

       130        140        150        160        170        180 
AQPSAPPPPA PPLPPTPSPP PPPPPPPPPA LSGYTTTNSG GGGSSGKGHS RDFVLRRDLS 

       190        200        210        220        230        240 
ATAPAAAMHG APLGGEQRSG TGSPQHPAPP PHSAGMFISA SGTYAGPDGS GGPALFPALH 

       250        260        270        280        290        300 
DTPGAPGGHP HPLNGQMRLG LAAAAAAAAA ELYGRAEPPF APRSGDAHYG AVAAAAAAAL 

       310        320        330        340        350        360 
HGYGAVNLNL NLAAAAAAAA AGPGPHLQHH APPPAPPPPP APAQHPHQHH PHLPGAAGAF 

       370        380        390        400        410        420 
LRYMRQPIKQ ELICKWIDPD ELAGLPPPPP PPPPPPPPPP AGGAKPCSKT FGTMHELVNH 

       430        440        450        460        470        480 
VTVEHVGGPE QSSHVCFWED CPREGKPFKA KYKLINHIRV HTGEKPFPCP FPGCGKVFAR 

       490        500        510        520        530        540 
SENLKIHKRT HTGEKPFKCE FDGCDRKFAN SSDRKKHSHV HTSDKPYYCK IRGCDKSYTH 

       550        560        570        580        590        600 
PSSLRKHMKI HCKSPPPSPG PLGYSSVGTP VGAPLSPVLD PARSHSSTLS PQVTNLNEWY 

       610        620        630 
VCQASGAPSH LHTPSSNGTT SETEDEEIYG NPEVVRTIH 

Q96T25 in FASTA format

View entry in raw text format (no links)
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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