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UniProtKB/Swiss-Prot entry Q96SL8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FIZ1_HUMAN
Primary accession number Q96SL8
Secondary accession number Q6ZMJ7
Integrated into Swiss-Prot on March 15, 2005
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 50)
Name and origin of the protein
Protein name Flt3-interacting zinc finger protein 1
Synonym Zinc finger protein 798
Gene name
Name: FIZ1
Synonyms: ZNF798
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Spleen, and Teratocarcinoma;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
TISSUE SPECIFICITY.
DOI=10.1093/hmg/ddg035; PubMed=12566383 [NCBI, ExPASy, EBI, Israel, Japan]
Mitton K.P., Swain P.K., Khanna H., Dowd M., Apel I.J., Swaroop A.;
"Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor.";
Hum. Mol. Genet. 12:365-373(2003).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK027674; BAB55286.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK160385; BAD18728.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00045801; -.
RefSeq NP_116225.2; -.
UniGene Hs.515617
3D structure databases
HSSP P08151; 2GLI. [HSSP ENTRY / PDB]
ModBase Q96SL8.
Organism-specific databases
GeneCards GC19M060795; -.
HGNC HGNC:25917; FIZ1.
GenAtlas FIZ1.
MIM 609133; gene. [NCBI / EBI]
Gene expression databases
ArrayExpress Q96SL8; -.
Bgee Q96SL8; -.
CleanEx HS_FIZ1; -.
GermOnline ENSG00000105066; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0005634; Cellular component: nucleus (inferred from sequence or structural similarity from UniProtKB).
GO:0003676; Molecular function: nucleic acid binding (inferred from electronic annotation from InterPro).
GO:0019901; Molecular function: protein kinase binding (inferred from sequence or structural similarity from UniProtKB).
GO:0005102; Molecular function: receptor binding (inferred from sequence or structural similarity from UniProtKB).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
IPR013087; Znf_C2H2/integrase_DNA-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 5.
Pfam PF00096; zf-C2H2; 8.
Pfam graphical view of domain structure.
ProDom PD000003; Znf_C2H2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00355; ZnF_C2H2; 11.
SMART graphical view of domain structure.
PROSITE PS00028; ZINC_FINGER_C2H2_1; 10.
PS50157; ZINC_FINGER_C2H2_2; 11.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q96SL8; -.
Genome annotation databases
Ensembl ENSG00000179943; Homo sapiens. [Contig view]
GeneID 84922; -.
KEGG hsa:84922; -.
Phylogenomic databases
HOGENOM Q96SL8; -.
HOVERGEN Q96SL8; -.
Other
NextBio 75332; -.
SOURCE FIZ1; Homo sapiens.
ProtoNet Q96SL8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   496  496     Flt3-interacting zinc finger protein 1. PRO_0000046937
ZN_FING   23    45  23     C2H2-type 1. 
ZN_FING   51    73  23     C2H2-type 2. 
ZN_FING   79   101  23     C2H2-type 3. 
ZN_FING   107   130  24     C2H2-type 4. 
ZN_FING   200   222  23     C2H2-type 5. 
ZN_FING   228   250  23     C2H2-type 6. 
ZN_FING   331   352  22     C2H2-type 7. 
ZN_FING   358   381  24     C2H2-type 8. 
ZN_FING   414   436  23     C2H2-type 9. 
ZN_FING   442   464  23     C2H2-type 10. 
ZN_FING   470   492  23     C2H2-type 11. 
MOD_RES   74    74        Phosphothreonine. 
CONFLICT   127   127        R -> K (in Ref. 1; BAD18728). 
Sequence information
Length: 496 AA [This is the length of the unprocessed precursor] Molecular weight: 51994 Da [This is the MW of the unprocessed precursor] CRC64: 937EEC713FFBD58F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDDVPAPTPA PAPPAAAAPR VPFHCSECGK SFRYRSDLRR HFARHTALKP HACPRCGKGF 

        70         80         90        100        110        120 
KHSFNLANHL RSHTGERPYR CSACPKGFRD STGLLHHQVV HTGEKPYCCL VCELRFSSRS 

       130        140        150        160        170        180 
SLGRHLRRQH RGVLPSPLQP GPGLPALSAP CSVCCNVGPC SVCGGSGAGG GEGPEGAGAG 

       190        200        210        220        230        240 
LGSWGLAEAA AAAAASLPPF ACGACARRFD HGRELAAHWA AHTDVKPFKC PRCERDFNAP 

       250        260        270        280        290        300 
ALLERHKLTH DLQGPGAPPA QAWAAGPGAG PETAGEGTAA EAGDAPLASD RRLLLGPAGG 

       310        320        330        340        350        360 
GVPKLGGLLP EGGGEAPAPA AAAEPSEDTL YQCDCGTFFA SAAALASHLE AHSGPATYGC 

       370        380        390        400        410        420 
GHCGALYAAL AALEEHRRVS HGEGGGEEAA AAAREREPAS GEPPSGSGRG KKIFGCSECE 

       430        440        450        460        470        480 
KLFRSPRDLE RHVLVHTGEK PFPCLECGKF FRHECYLKRH RLLHGTERPF PCHICGKGFI 

       490 
TLSNLSRHLK LHRGMD 

Q96SL8 in FASTA format

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